碘化氰置于盐酸体系中,化学反应生成 一氯化碘 参考文献:Chattaway,F. D.; Wadmore,J. M.,Journal Of The Chemical Society,1902,Vol. 81,P. 197-197 标题:Chattaway,F. D.; Wadmore,J. M.,Journal Of The Chemical Society,1902,Vol. 81,P. 197-197
专利信息
专利号:US-6252079-B1 优先权日:1993-06-30 标 题 :Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof 发明人:CURRAN DENNIS P; BOM DAVID 权利人:UNIV PITTSBURGH 摘要:The present invention provides a short, convergent total synthesis of irinotecan and derivative compounds which comprises of a novel 4+1 radical annulation wherein the precursoris reacted with an aryl isonitrile having the formulawherein X is Br or I, and R4 is an alkyl group, an allyl group, a propargyl group or a benzyl group, and R16 is H, a C1-C6 alkoxy group, agroup wherein p is an integer between 4 and 12, or a C1-C12 acyclic dialkylamino group. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.
专利号:US-8269001-B2 优先权日:2005-10-05 标题 :Process for the synthesis of HMG-CoA reductase inhibitors 发明人:CASAR ZDENKO 权利人:CASAR ZDENKO; LEK PHARMACEUTICALS 摘要:A novel synthesis of statins uses Wittig reaction of a heterocyclic core of statin with a lactonized side chain already possessing needed stereochemistry. Any separation of diastereoisomers is performed early in the course of synthesis.
专利号:US-6982333-B2 优先权日:1993-06-30 标 题:Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof 发明人:CURRAN DENNIS P; JOSIEN HUBERT; KO SUNG BO 权利人:UNIV PITTSBURGH 摘要:The present invention provides a short, convergent total synthesis of camptothecin and related compounds which consists of a novel 4+1 radical annulation. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.
专利号:US-11858901-B2 优先权日:2019-10-30 标 题:3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6 trifluoromethyl benzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, process for its preparation, and its use in the synthesis of elagolix 发明人:BALLETTE ROBERTO; JIMÉNEZ ALONSO OSCAR; GARCÃ?A GARCÃ?A ELENA; DOBARRO RODRÃ?GUEZ ALICIA 权利人:MOEHS IBERICA SL 摘要:A new intermediate is useful in the synthesis of elagolix. A process for obtaining the intermediate includes reacting a precursor with iodine monochloride in the presence of an organic solvent. A process for preparing elagolix makes use of the intermediate. The intermediate can be 3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, such as a hydrochloride.
专利号:US-8969619-B2 优先权日:2009-07-21 标题:Synthesis of iodixanol in propyleneglycol 发明人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE 权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE; GE HEALTHCARE AS 摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with propyleneglycol as solvent.
专利号:EP-1373548-B1 优先权日:2002-04-08 标 题 :Chemo-enzymatic synthesis of optically enriched rose-oxides 发明人:TANEJA SHUBASH CHANDRA; SETHI VIJAY KUMAR; KOUL SURRINDER; ANDOTRA SAMAR SINGH; QAZI GHULAM NABI 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to a process for the synthesis of optically enriched dextro- and leavo-rotatory isomers of rose oxide from racemic citronellol.