CAS: 7053-88-5; 2-Hydroxy-3-Isopropylbenzoic Acid

该化合物是代用苯并二甲酸衍生物,分别在芳香环的2个和3个位置分别以羟基和异丙基功能组为主,这种结构安排具有独特的物理化学特性,包括有机溶剂中的溶解性增强和进一步功能化的可能性.该化合物对合成有机化学感兴趣,特别是作为制药,农用化学品和特殊材料的中间体.其苯丙基和盒式酸功能允许多种再活性,在切热,催化和聚合合成中进行赋能应用.该异丙基酸组可产生消毒和电子效应,影响其稳定性和在各种化学变异中的再活动.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

3-Isopropylsalicylic acid methyl ester 2-hydroxy-3-isopropyl-benzoic acid isopropyl ester 2-(1-methylethyl)phenol carbon dioxide 2-(1-methylethyl)phenol benzyl-3-isopropyl salicylate benzyl 2-benzyloxy-3-isopropylbenzoate phenacyl-3-isopropyl salicylate

合成工艺路线路线简述

    📜异丙苯酚置于silver Nitrate,三乙胺,Sodium Hydroxide,Magnesium Chloride体系中,用 四氢呋喃,乙醇 作为反应溶剂,化学反应 4.83H,反应生成 2-羟基-3-异丙基苯甲酸
    参考文献: Analogs Of Propofol,Preparation Thereof And Use As Anesthetics[fr] Analogues De Propofol,Leur Préparation Et Leur Utilisation Comme Anesthésiques
    标题: Analogs Of Propofol,Preparation Thereof And Use As Anesthetics[fr] Analogues De Propofol,Leur Préparation Et Leur Utilisation Comme Anesthésiques
    摘要:式(i)中x为h或f的化合物及其药学上可接受的盐可用作麻醉药.

    海关参考信息

    专利信息


    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: M D Krasowski, Et Al. General Anesthetic Potencies Of A Series Of Propofol Analogs Correlate With Potency For Potentiation Of Gamma-Aminobutyric Acid (Gaba) Current At The Gaba(A) Receptor But Not With Lipid Solubility. J Pharmacol Exp Ther. 2001 Apr;297(1):338-51.

    合成参考文献


    摘要:Farmaco, Edizione Scientifica., 20(506), 1965 []
    摘要:M. V. Park, Nature (London) 197, 283 (1963).
    参考文献:10.1021/jm010461a
    摘要:Krasowski MD, Hong X, Hopfinger AJ, Harrison NL. 4D-QSAR Analysis of a Set of Propofol Analogues: Mapping Binding Sites for an Anesthetic Phenol on the GABAA Receptor. J. Med. Chem. 2002 Jun 14;45(15):3210–21. doi: 10.1021/jm010461a.
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