CAS: 69703-25-9; 7,16-Dibenzyl-1,4,10,13-Tetraoxa-7,16-Diazacyclooctadecane

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23978-55-4 10316-00-4 119580-47-1

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📜苄胺置于sodium Carbonate,Sodium Iodide体系中,用 乙腈 作为反应溶剂,化学反应生成 N,N'-二苄基-4,13-二氮杂-18-冠6-醚
参考文献:对15和18元环的diaza-Bibracchial套索状醚(bibles)的新型合成途径以及阳离子结合中的侧链-宏配位合作性的研究
标题:对15和18元环的diaza-Bibracchial套索状醚(bibles)的新型合成途径以及阳离子结合中的侧链-宏配位合作性的研究
摘要:提出了一种非常实用的4,10-Diaza-15-Crown-5,4,13-Diaza-18-Crown-6及其对称的n,N'-二取代衍生物的合成方法,以及首次进行的阳离子结合研究15元环系统的数据.
DOI:10.1016/s0040-4039(00)84009-5

专利信息

专利号:US-2025082793-A1
优先权日:2021-11-09
标 题 :Macrocyclic compounds and methods of making the same
发明人：CLEATOR EDWARD; MATON WILLIAM MARC; SALTER RHYS
权利人:JANSSEN BIOTECH INC
摘要:The present invention is directed to the preparation of key intermediates and synthesis of compounds (macrocyclic compounds) and pharmaceutically acceptable salts thereof, immunoconjugates, radioimmunoconjugates thereof, pharmaceutical compositions containing said compounds and immunoconjugates, radioimmunoconjugates thereof.

专利号:US-5247078-A
优先权日:1991-05-02
标题:Synthesis of diaza crown ethers
发明人：CHAMPION DONALD H; SPERANZA GEORGE P; RENKEN TERRY L
权利人:TEXACO CHEMICAL
摘要:Poly(ethyleneoxy)amines, such as those having the structure: H2N-(CH2)a-(OCH2CH2)b-NH-(CH2CH2O)c-(CH2)d-R where a and d are independently 2 to 3; b and c are independently 1 to 4 and R is -OH or -NH2, may be reacted over a transition metal catalyst such as one containing nickel to produce diaza crown ethers, such as, for example 4,13-diaza-18-crown-6. If the poly(ethyleneoxy)amine is a diamine having a hydroxyl group of the above formula, the reaction may produce the corresponding triamine in the presence of ammonia. These triamines also readily form diaza crown ethers at near complete conversions simply from nickel, platinum, and palladium metal catalysts alone or with other transition metals such as copper and/or chromium. The process avoids tedious, multiple step procedures and the high dilutions that accompany prior diaza crown ether preparations.