CAS: 6901-22-0; Lunasine

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      专利号:US-2003224420-A1
      优先权日:2002-04-05
      标题 :Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
      发明人:HELLERSTEIN MARC K; KIM SYLVIA JEEWON
      摘要:This invention relates to a method for separating long-term label retaining cells or stem cells. In particular, this invention relates to a method for separating long-term label retaining cells and/or stem cells from tissues or individuals and for measuring proliferation rates of long-term label retaining cells and stem cells, as well as determining clonal expansion (proliferative history) of cell lineages from the tissues of the individual. The cells may be double-labeled with a cell-lineage marking label and isotopically labeled DNA synthesis precursor prior to physical separation.

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      1: Yang X, Zhu J, Tung CY, Gardiner G, Wang Q, Chang HC, Zhou B. Lunasin alleviates allergic airway inflammation while increases antigen-specific Tregs. PLoS One. 2015 Feb 3;10(2):e0115330. doi: 10.1371/journal.pone.0115330. eCollection 2015.
      2: Chang HC, Lewis D, Tung CY, Han L, Henriquez SM, Voiles L, Lupov IP, Pelloso D, Sinn AL, Pollok KE, de Lumen BO, Li F, Blum JS, Srivastava S, Robertson MJ. Soypeptide lunasin in cytokine immunotherapy for lymphoma. Cancer Immunol Immunother. 2014 Mar;63(3):283-95. doi: 10.1007/s00262-013-1513-8. Epub 2013 Dec 22.
      3: Dinelli G, Bregola V, Bosi S, Fiori J, Gotti R, Simonetti E, Trozzi C, Leoncini E, Prata C, Massaccesi L, Malaguti M, Quinn R, Hrelia S. Lunasin in wheat: a chemical and molecular study on its presence or absence. Food Chem. 2014 May 15;151:520-5. doi: 10.1016/j.foodchem.2013.11.119. Epub 2013 Nov 27. Review. Polish. doi: 10.3390/ijms151223705.
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