CAS: 66898-62-2; 3-Oxo-1,3-Dihydroisobenzofuran-1-Yl 2-((3-(Trifluoromethyl)Phenyl)Amino)Nicotinate

上下游产品

CAS号6940-49-4 3-溴苯酞 | CAS号4394-00-7 氟尼酸 | CAS号98-16-8 间三氟甲苯胺 | CAS号73791-49-8 2-cloronicotino... | CAS号2942-59-8 2-氯烟酸

📜2-氯烟酸置于三乙胺,Sodium Iodide体系中,用 丙酮,Xylene 作为反应溶剂,化学反应 6.0H,反应生成 他尼氟酯
参考文献:Los,M.; Boned,J. E.; Piccinali,C.,Farmaco,Edizione Pratica,1981,Vol. 36,# 5,P. 372-385
标题:Los,M.; Boned,J. E.; Piccinali,C.,Farmaco,Edizione Pratica,1981,Vol. 36,# 5,P. 372-385

专利信息

专利号:US-8546532-B2
优先权日:2008-04-17
标题:Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
发明人：BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS
权利人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS; DECLION PHARMACEUTICALS INC
摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:US-4255581-A
优先权日:1979-08-13
标题 :Process for the preparation of alkyl and aryl esters of 3'-substituted and 2', 3'-disubstituted 2-anilino-3-pyridinecarboxylic acids
发明人：LOS MARIO A
权利人:LAB BAGO S A
摘要:In this disclosure, the synthesis of alkyl and aryl esters of substituted 2-anilino-3-pyridinecarboxylic acids is described. This preparation is performed reacting a previously obtained alkyl or aryl ester of 2-chloro-3-pyridinecarboxylic acid, with 3,2 or 3-substituted aniline.

专利号:US-7504409-B2
优先权日:2000-01-31
标 题:Mucin synthesis inhibitors
发明人：ZHOU YUHONG; LEVITT ROY C; NICOLAIDES NICHOLAS C; JONES STEVE; MCLANE MIKE
权利人:GENAERA CORP
摘要:The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and chronic bronchitis, inflammatory lung diseases, cystic fibrosis and acute or chronic respiratory infectious diseases.

专利号:US-2005249675-A1
优先权日:2003-06-19
标 题 :Mucin synthesis inhibitors
发明人：HUNG HSIAO-LING; CHELLQUIST ERIC; LEVITT ROY C; MCLANE MICHAEL
权利人:HUNG HSIAO-LING; CHELLQUIST ERIC; LEVITT ROY C; MCLANE MICHAEL
摘要:The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and chronic bronchitis, inflammatory lung diseases, cystic fibrosis and acute or chronic respiratory infectious diseases.