CAS: 66673-40-3; (R)-(-)-5-(Hydroxymethyl)-2-Pyrrolidinone

相似化合物

62400-75-3 17342-08-4 81658-25-5

上下游产品

CAS号64700-65-8 (R)-(-)-2-吡咯酮-5-甲酸甲酯 | CAS号68766-96-1 D-焦谷氨酸乙酯 | CAS号6893-26-1 D-谷氨酸 | CAS号4042-36-8 d-焦谷氨酸 | CAS号13107-55-6 D-glutamic acid... | CAS号4042-36-8 d-焦谷氨酸 | CAS号98612-60-3 (R)-5-溴甲基-2-吡咯烷酮 | CAS号128899-30-9 5(R)-5-{(叔丁基二甲基... | CAS号128811-37-0 B°C-D-焦谷胺醇 | CAS号138541-53-4 (R)-5-(CHLOROME... | CAS号1558-60-7 (S)-5-甲基吡咯烷-2-酮 | CAS号118918-76-6 (3S,7aR)-3-Phen... | CAS号118867-99-5 (3S,7aR)-3-Phen...

D-焦谷氨酸置于sodium Tetrahydroborate,氯化亚砜体系中,用 异丙醇 作为反应溶剂,化学反应 68.0H,反应生成 (R)-(-)-5-羟甲基-2-吡咯烷酮
参考文献:Cytochalasans的合成方法part9.导致细胞松弛素所有结构类型的通用概念†
标题:Cytochalasans的合成方法part9.导致细胞松弛素所有结构类型的通用概念†
摘要:从d-谷氨酸(5)开始,通过17(方案1和2)合成了双环化合物4A和4B.用licuph 2导致4G和4H的反应不成功.但治疗n-保护的模型的内酰胺19,21,和22与li 2的cu(cn)ph 2,得到氨基酮24,26,和27,分别为(方案3).所需化合物23从得到20转换未受保护内酰胺的28,31,和32,得到苯基衍生物34以非常好产率.酯35被转化为α-氨基-γ-氧代酸衍生物36.这种转化打开了对这类化合物的新颖途径.
DOI:10.1002/hlca.19900730113

专利信息

专利号:US-6949553-B2
优先权日:2001-06-18
标题 :Aliphatic compounds, their synthesis method, and utilization of the same
发明人：TAMAI TADAKAZU; YOSHIKAI KAZUYOSHI; NISHIKAWA MASAZUMI; OGASAWARA KUNIO; MUROTA ITSUKI
权利人:MARUHA CORP
摘要:The present invention relates to aliphatic compounds of the formula I, or stereoisomers thereof, or their pharmaceutically acceptable salts: n n nwherein A represents an optionally substituted CH 3 C n H (2n-2m) — (wherein n denotes an integer of 4 to 22, and m represents an unsaturation number which is an integer of 0 to 7), l represents an integer of 0 to 10, s represents 0 or 1, provided that when s is 0, p+q=4 or 5, but when s is 1, p+q=3 or 4, and in each case, either p or q is an integer of 1 or more, R represents an alkyl group having 1 to 10 carbon atoms which may be straight-chain or branched-chain, and R A represents hydrogen or an alkyl group having 1 to 10 carbon atoms which may be straight-chain or branched-chain, and their use in suppression of platelet aggregation, in suppression of inflammation, and in prevention and treatment of circulatory diseases.

专利号:JP-6368351-B2
优先权日:2013-03-15
标 题 :Method for the synthesis of difluorolactam analogues

专利号:US-9879022-B2
优先权日:2014-04-04
标题:Bicyclic-fused heteroaryl or aryl compounds
发明人：TRZUPEK JOHN DAVID; LEE KATHERINE LIN; BUNNAGE MARK EDWARD; HAN SEUNGIL; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; MATHIAS JOHN PAUL; PAPAIOANNOU NIKOLAOS; PIERCE BETSY SUSAN; STROHBACH JOSEPH WALTER; WRIGHT STEPHEN WAYNE; ZAPF CHRISTOPH WOLFGANG; GAVRIN LORI KRIM; LEE ARTHUR; ANDERSON DAVID RANDOLPH; CURRAN KEVIN JOSEPH; DEHNHARDT CHRISTOPH MARTIN; SAIAH EDDINE; GOLDBERG JOEL ADAM; WANG XIAOLUN; HUANG HORNG-CHIH; VARGAS RICHARD; LOWE MICHAEL DENNIS; PATNY AKSHAY
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:EP-1408030-A1
优先权日:2001-06-18
标 题:Novel aliphatic compound, method of synthesis, and method of utilization

专利号:US-2004162435-A1
优先权日:2001-06-18
标题 :Novel aliphatic compound, method of synthesis, and method of utilization

专利号:EP-1408030-B1
优先权日:2001-06-18
标题:Novel aliphatic compound, method of synthesis, and method of utilization