CAS: 610-02-6; 2,3,4-Trihydroxybenzoic Acid

该化合物是一种自然产生的苯丙酸化合物,其分子式为C7H6O5.该化合物含有三个附于苯环的氢氧(-OH)组,有助于其强烈的抗氧化性特性.该化合物通常存在于各种植物中,特别是核桃,茶叶和某些水果中.该化合物以其能够捕食自由基,使其在食品保存和医药应用中都具有价值而闻名.它具有抗微生物和抗炎特性,而且经常用于传统医药和饮食补充.此外,它也是合成各种化学化合物,包括钽和染料的前体.该化合物在水和酒精中可溶解,其毒性特征相对较低,适合药物,化妆品和食品工业中的各种应用.其稳定性和再活性可受到PH和温度的影响,而这些是其应用中的重要考虑因素.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

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CAS号89-86-1 2,4-二羟基苯甲酸 | CAS号87-66-1 1,2,3-苯三酚 | CAS号28752-90-1 acetyl fraxinol | CAS号124-38-9 二氧化碳 | CAS号4435-88-5 3-formyl-2,4-di... | CAS号634-36-6 1,2,3-三甲氧基苯 | CAS号298-14-6 碳酸氢钾 | CAS号7732-18-5 水 | CAS号65-85-0 苯甲酸 | CAS号32361-59-4 Benzenecarbodit... | CAS号5653-46-3 2-羟基-3,4-二甲氧基苯甲酸 | CAS号31127-54-5 2,3,4,4'-四羟基二苯甲酮 | CAS号27163-60-6 4,5,6-trihydrox... | CAS号87-66-1 1,2,3-苯三酚 | CAS号52479-85-3 依昔苯酮 | CAS号573-11-5 2,3,4-三甲氧基苯甲酸 | CAS号523-80-8 芹菜脑 | CAS号1143-72-2 2,3,4-三羟基二苯甲酮 | CAS号23731-75-1 4,7-dimethoxy-1... | CAS号72023-44-0 2,3,4,5-tetrame...

合成工艺路线路线简述

    2,4-二羟基苯甲酸置于ferrous(II) Sulfate Heptahydrate,双氧水体系中,用 水 作为反应溶剂,化学反应生成 2,3,4-三羟基苯甲酸
    参考文献:Fenton和photo-Fenton过程对2,4-二羟基苯甲酸的氧化降解:动力学,机理和o2取代h2O2的证据
    标题:Fenton和photo-Fenton过程对2,4-二羟基苯甲酸的氧化降解:动力学,机理和o2取代h2O2的证据
    摘要:通过fenton和光fenton工艺对2,4-二羟基苯甲酸(2,4-Dhba)氧化降解的动力学和机理进行了详细的HPLC,Ic和toc分析.2,3,4-三羟基苯甲酸(2,3,4-Thba)在早期氧化阶段的形成表明芳环的羟基化是该过程的第一步.该中间体能够还原fe Iii,并有助于fe Ii的循环利用.完全矿化只能在辐照下完成(照片fenton).矿化速率对H2O 2和溶解o浓度的依赖性的详细研究进行了2次.发现即使在H2O 2的初始浓度较低的情况下,只要o 2浓度足够高,则通过光芬顿法完成的矿化过程将在相对较短的时间内完成,这表明o 2至少可以部分替代H2O 2.引导反应途径通向o 2而不是H2O 2消耗对于光芬顿法的技术发展尤为重要.
    DOI:10.1002/hlca.200900380

    海关参考信息

    专利信息


    专利号:US-6180830-B1
    优先权日:1995-11-08
    标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
    发明人:JACQUOT ROLAND
    权利人:RHODIA CHIMIE SA
    摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

    专利号:US-6388156-B1
    优先权日:1999-05-14
    标题 :Direct selective synthesis of para-xylene by reacting an aromatic compound with a methylating agent formed from CO, Co2 and H2
    发明人:OU JOHN D Y; JANDA GARY F; HONG ZONGXUAN; SELLEN RUSSELL D
    权利人:EXXONMOBIL CHEM PATENTS INC
    摘要:It has been discovered that para-xylene (PX) can be synthesized with improved selectivity by reacting an aromatic compound such as toluene and/or benzene with a reactant(s) such as a combination of hydrogen and carbon monoxide and/or carbon dioxide and/or methanol or methylating agents produced therefrom. Catalytic reaction systems are employed, such as crystalline or amorphous aluminosilicates having one-dimensional channel structure, para-alkyl selectivated crystalline or amorphous aluminosilicates, para-alkyl selectivated substituted aluminosilicates, crystalline or amorphous substituted silicates having one-dimensional channel structure, para-alkyl selectivated substituted silicates, crystalline or amorphous aluminophosphates, para-alkyl selectivated crystalline or amorphous aluminophosphates, para-alkyl selectivated zeolite-bound zeolite and para-alkyl selectivated substituted aluminophosphates, and mixtures thereof. The catalytic reaction systems may be selectivated with organometallic compounds, compounds of elements selected from Groups 1 through 16, coke, and mixtures thereof. Using this process, catalyst stability and life is improved.

    专利号:US-9453037-B2
    优先权日:2011-07-28
    标 题 :Methylphenidate-prodrugs, processes of making and using the same
    发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
    权利人:KEMPHARM INC; KEMPHARM INC
    摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

    专利号:US-10188136-B2
    优先权日:2016-02-16
    标题:Hydrophobin mimics: process for preparation thereof
    发明人:BRITTO Sandanaraj Selvaraj; REDDY Mullapudi Mohan; BHANDARI PAVANKUMAR JANARDHAN; RAO KASULADEVU JAGANNADHA
    权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES
    摘要:The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles/nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.

    专利号:US-11078526-B2
    优先权日:2016-02-11
    标 题:Polyphenolic additives in sequencing by synthesis
    发明人:OLEJNIK JERZY; Perbost Michel Georges
    权利人:ISOPLEXIS CORP
    摘要:The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis methods. In particular, the present invention contemplates the use of polyphenolic compounds, known as antioxidant additives, to improve the efficiency of Sequencing-By-Synthesis reactions. For example, gallic acid (GA) is shown herein to be one of many exemplary SBS polyphenolic additives.

    专利号:US-12071507-B2
    优先权日:2014-01-10
    标 题:Method and composition for improving adhesion of metathesis compositions to substrates
    发明人:STEPHEN ANTHONY R; CRUCE CHRISTOPHER J; TRIMMER MARK S; GIARDELLO MICHAEL A
    权利人:MATERIA INC
    摘要:A method of improving the adhesion of metathesis compositions, such as ring-opening metathesis polymerization (ROMP) compositions, to a substrate is disclosed, in which an adhesion promoter is added to a polymerizable resin composition in order to improve the adhesion of the polymerizing resin to a substrate material. The addition of the adhesion promoter has been found to provide beneficial improvements in the adhesion of metathesis, especially ROMP, compositions to substrates, particularly glass surfaces, leading to improved characteristics in ROMP materials formed therefrom. The adhesion promoter generally comprises a functionalized silane compound and a peroxide compound. A ROMP composition is further disclosed comprising a cyclic olefin, a ROMP metathesis catalyst, and the adhesion promoter. Polymer products produced via metathesis (ROMP) reactions of the invention may be utilized to provide a wide range of materials and in a variety of composite applications. The invention has utility in the fields of catalysis, organic synthesis, and polymer and materials chemistry and manufacture.
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    主要参考文献

    [参考文献]: A A Mohamed, Et Al. Catalytic Spectrophotometric Determination Of Vanadium In Seawaters Based On The Bromate Oxidative Coupling Reaction Of Metol And 2,3,4-Trihydroxybenzoic Acid. Anal Sci. 2001 Jun;17(6):769-73.
    [参考文献]: Asuka Kodama, Et Al. Oxidative Dimer Produced From A 2,3,4-Trihydroxybenzoic Ester. Biosci Biotechnol Biochem. 2007 Jul;71(7):1731-4.
    [参考文献]: Mohamed A Farag, Et Al. Structure-Activity Relationships Of Antimicrobial Gallic Acid Derivatives From Pomegranate And Acacia Fruit Extracts Against Potato Bacterial Wilt Pathogen. Chem Biodivers. 2015 Jun;12(6):955-62.
    [参考文献]: Rebecca J Robbins, Et Al. Development Of A Quantitative High-Performance Liquid Chromatography-Photodiode Array Detection Measurement System For Phenolic Acids. J Chromatogr A. 2004 Jun 4;1038(1-2):97-105.

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1021/np0600999
    摘要:Reynertson KA, Wallace AM, Adachi S, Gil RR, Yang H, Basile MJ, D'Armiento J, Weinstein IB, Kennelly EJ. Bioactive Depsides and Anthocyanins from Jaboticaba (Myrciaria cauliflora). J. Nat. Prod. 2006 Aug 01;69(8):1228–30. doi: 10.1021/np0600999.
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