CAS: 57-10-3; Hexadecanoic Acid

相似化合物

112-39-0 36653-82-4 628-97-7

上下游产品

CAS号36653-82-4 十六醇 | CAS号555-44-2 (三)棕榈酸甘油酯 | CAS号628-97-7 棕榈酸乙酯 | CAS号112-39-0 棕榈酸甲酯 | CAS号629-80-1 十六醛 | CAS号1492-30-4 棕榈酸对硝基苯酯 | CAS号5399-02-0 十七烷腈 | CAS号114119-34-5 methyl 5-thiast... | CAS号629-54-9 棕榈酰胺 | CAS号1070-54-8 hentriacontan-16-ol | CAS号555-44-2 (三)棕榈酸甘油酯 | CAS号34607-52-8 1,2-dipalmitoyl... | CAS号1042289-75-7 1,2-Dipalmitoyl... | CAS号502-52-3 1,3-双棕榈酸甘油酯 | CAS号544-31-0 十六酰胺乙醇 | CAS号542-42-7 棕榈酸酯(钙盐) | CAS号601-34-3 棕榈酸胆固醇酯 | CAS号56255-31-3 N-十六碳酰基-L-丙氨酸

三棕榈酸甘油酯置于sodium Hydroxide体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 2.5H,反应生成 棕榈酸
参考文献:酯碱水解的简单方法
标题:酯碱水解的简单方法
摘要:通过使用二氯甲烷/甲醇(9:1)作作为反应溶剂,已经开发出一种非常温和,快速的方法,可在非水条件下有效地进行酯的碱性水解.该方法可在室温下几分钟内方便地由相应的酯和氢氧化钠提供羧酸和醇.提出了合理的反应机理.
DOI:10.1016/j.Tetlet.2007.09.074

专利信息

专利号:WO-2012004653-A8
优先权日:2010-07-07
标 题:Method for inhibition of nf-kb gene expression
发明人：BHATTACHARYA SUSHMITA; DASGUPTA SUMAN; BARMA POMY; BISWAS ANINDITA; PAL BIKASH CHANDRA; BHATTACHARYA SHELLEY; BHATTACHARYA SAMIR; BORDOLOI MANOBJYOTI; BARUA NABIN CHANDRA; RAO PARUCHURI GANGADHAR
权利人:COUNCIL SCIENT IND RES; VISVA BHARATI SCHOOL OF LIFE SCIENCES; BHATTACHARYA SUSHMITA; DASGUPTA SUMAN; BARMA POMY; BISWAS ANINDITA; PAL BIKASH CHANDRA; BHATTACHARYA SHELLEY; BHATTACHARYA SAMIR; BORDOLOI MANOBJYOTI; BARUA NABIN CHANDRA; RAO PARUCHURI GANGADHAR
摘要:The present invention discloses a method of inhibition of synthesis of NF- kB by inhibiting its gene expression using isoflavones Daidzein and Daidzin. Daidzein, a non toxic dietary supplement isoflavone of the structure (1) and 7-O-ϵ-glucopyranosyl daidzein of the structure (2) are novel inhibitors of NF- kB which blocks the synthesis of NF- kB by inhibiting its gene expression and have no toxic effect. Both daidzein of the structure (1) and daidzin of the structure (2) ameliorate palmitate induced overexpression of NF- kB in skeletal muscle cells by eliminating the inhibition of NF- kB on insulin stimulated glucose uptake. Daidzein inhibits NF- kB expression in prostate and breast cancer cells that increased mortality of these cancer cells. Daidzin of the structure (2) has very good bioavailibility over daidzein of structure (1). Daidzein of the structure (1) is not absorbed when orally fed to mice as it is eliminated from the gut through glucuronidation process catalyzed by UGT1. Daidzin of the structure (2) is glucosylated daidzein and is protected from UGT1 mediated degradation and is hydrolysed to daidzein which is absorbed and remains for more than 4 hours in blood and is expected to be distributed to different tissues and organs. Daidzein of the structure (1) and daidzin of the structure (2) reduce palmitate stimulated increased synthesis of NF- kB significantly. Daidzein inhibits formation of NF- kB -DNA complex stimulated by palmitate and both daidzein and daidzin inhibited NF- kB expression which leads to reduction of its DNA binding. Daidzein of the structure(1) was obtained from soy leaves through chromatography and both natural and synthetic daidzein and daidzin have same biological activities.

专利号:WO-2022034429-A1
优先权日:2020-08-10
标 题 :PROCESS OF SYNTHESIS OF β-6'SULFOQUINOVOSYL DIACYLGLYCEROLS
发明人：MANZO EMILIANO; FONTANA ANGELO; ZIACO MARCELLO
权利人:BIOSEARCH S R L
摘要:The present invention relates to a synthesis process of β-6-sulfoquinovosyl-diacylglycerols. In particular, said process is for the synthesis of the compounds 1,2-O-distearoyl-3-O-(β- sulfoquinovosyl)- R/S -glycerol, 1,2-O-distearoyl-3-O-(β-sulfoquinovosyl)- R -glycerol or 1,2- O-distearoyl-3-O-(β-sulfoquinovosyl)- S -glycerol, named respectively Sulfavant A, Sulfavant R and Sulfavant S.

专利号:US-11066439-B2
优先权日:2016-12-10
标题 :Synthesis of liraglutide
发明人：GANGA RAMU VASANTHAKUMAR; PATIL NITIN; CHARYULU PALLE VENKATA RAGHAVENDRA; JASMINE CASTELINO ROOPA; MACHANI RAMBABU; SUVARNA DEEPA SHANKAR
权利人:BIOCON LTD
摘要:The present invention relates to the efficient solid-phase synthesis of liraglutide represented by Formula-I. The present invention relates to an efficient process for the preparation of liraglutide by sequential coupling employing solid phase approach. It involves sequential coupling of protected amino acids to prepare backbone of liraglutide and upon completion of linear sequence, synthesis was extended from lysine side chain by adding γ-glutamic acid and palmitic acid, followed by removal of protective groups, cleavage of the peptide from solid support and purification of crude liraglutide obtained. The present invention also involves the usage of inorganic salts during the coupling, wash with HOBt in DMF solution after Fmoc-deprotection step to suppress the aggregation of peptides and ensure reactions are going for completion, and thus avoid deletion sequences and improve the process yield.

专利号:US-2025101045-A1
优先权日:2022-01-18
标题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives
发明人：DAS BHASKAR
权利人:LONG ISLAND UNIV
摘要:The present disclosure is concerned with borylated amidoximes useful in the synthesis of biologically relevant drug-like molecules, including functionalized oxadizole and quinazolinone derivatives. Also disclosed are methods of making borylated amidoximes, methods of making functionalized oxadiazole and quinazolinone compounds using the amidoximes, and functionalized oxadiazole and quinazolinone compounds prepared from borylated amidoximes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-8383810-B2
优先权日:2004-12-20
标题:Process for the synthesis of azetidinones
发明人：THIRUVENGADAM TIRUVETTIPURAM K; CHIU JOHN S; FU XIAOYONG; MCALLISTER TIMOTHY L
权利人:MERCK SHARP & DOHME; THIRUVENGADAM TIRUVETTIPURAM K; CHIU JOHN S; FU XIAOYONG; MCALLISTER TIMOTHY L
摘要:A process is provided for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, comprising reacting a β-(substituted-amino)amide, a β-(substituted-amino)acid ester, or a β-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride, wherein a quaternary ammonium moiety of the cyclizing agent is unsubstituted or substituted by one to four groups independently selected from the group consisting of alkyl, arylalkyl and arylalkyl-alkyl.

专利号:WO-2010115578-A3
优先权日:2009-04-03
标 题:Enzymatic preparation of fatty acid esters for diesel fuel
发明人：HELD MARTIN; PANKE SVEN
权利人:ETH ZUERICH; HELD MARTIN; PANKE SVEN
摘要:Novel Diesel substitutes or supplements as well as routes for their synthesis are disclosed. The subject compounds comprise esters assembled from a fatty acid and an alcohol component. According to the invention, the fatty acid component of the esters is selected from the list of nonanoic acid, decanoic acid, undecanoic acid, dodecanoic acid, tridecanoic acid, tetradecanoic acid, and pentadecanoic acid, hexadecanoic acid, heptadecanoic acid, and ocatadecanoic aicd while the alcohol component is selected from the list of ethanol, 1- propanol, 2-propanol, 2-methylpropanol, 1-butanol, or 2-butanol. The disclosed compounds are highly chemically stable and solve the dilemma between deteriorating auto-ignition properties and cetane numbers of Diesel fuel compounds at improved suitability for application at cold-temperatures. Furthermore, methods for synthesis of the said compounds are provided. In one embodiment, the fatty acid component of the disclosed esters are synthesized by a single process from renewable feed stocks such as plant material, municipal, industrial or agricultural waste and by aid of microbial catalysts or fermentation while the alcohol component is synthesized by another process by means of petro-chemistry or microbial catalysis. In one embodiment, the ester is then formed in a third process and while using biological or chemical catalysts while in another embodiment the alcohol is added to the microbial process employed for synthesis of the fatty acid component and the fatty acid ester is then formed concomitant to the microbial catalyzed fatty acid synthesis. In yet another embodiment, the esters are synthesized directly, i.e. in a single process, from renewable resources and by aid of a microbial biocatalyst. The methods for synthesis of the disclosed compounds solve the problem of high cost and low availability of fatty acid esters.