(2R,3R)-3-Heptadecafluorooctyl-2-Pent-4-Ynyloxy-Tetrahydro-Pyran置于甲醇,对甲苯磺酸体系中,用 四氢呋喃 作为反应溶剂,化学反应 24.0H,以94%的收率获得产物4-戊炔-1-醇 参考文献:Synthesis And Applications Of A Fluorous Thp Protective Group 标题:Synthesis And Applications Of A Fluorous Thp Protective Group 摘要:A Recyclable Fluorous Labeled Thp Protecting Group Has Been Developed That Allows For Simple Purification Of Small Molecules By Liquid-Liquid Extraction With Fc-72/mecn,And Of Larger Or More Polar Molecules By Solid Phase Extraction With Fluorous Reverse Phase Silica Gel. In Addition,We Report A New Glycosylation Method Which Uses The Cp2Zrcl2-Agclo4 Reagent System To Activate An Anomeric Sulfoxide. (C) 1999 Elsevier Science Ltd. All Rights Reserved. DOI:10.1016/s0040-4039(99)00866-7
专利号:US-9920160-B2 优先权日:2014-09-03 标题 :Method for synthesis of polymer containing multiple epoxy groups 发明人:GAO CHAO; ZHENG YAOCHEN; PENG LI; CAI SHENGYING; WENG ZHULIN 权利人:UNIV ZHEJIANG 摘要:A method for a synthesis of a polymer containing multiple epoxy groups includes steps of: under protection of nitrogen or argon, with a photosensitive free radical initiator under an ultraviolet light irradiation, initiating a mixture of a dithiol compound and alkynyl glycidyl ether or other alkynyl-containing compounds to proceed a thiol-yne polymerization, so as to obtain the polymer. The number of the epoxy groups is able to be adjusted through changing a type of a dithiol monomer, a mixing ratio of the dithiol monomer, and a mixing ratio between the alkynyl glycidyl ether and other alkynyl compounds. The present invention has advantages of: fast reaction, convenient process, easy post-processing, a large number of the epoxy groups, and adjustable and controllable content. The obtained polymer has a wide potential application in fields of coating, adhesive, ink, encapsulating material, resin for composite material, additive, high performance material, function material, and so on.
专利号:US-8183355-B2 优先权日:2006-04-28 标题 :Method for the synthesis of oligonucleotide derivatives 发明人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE 权利人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE; CENTRE NAT RECH SCIENT 摘要:Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistryâ€? reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. n Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.
专利号:US-10829792-B2 优先权日:2017-03-21 标 题 :Biocatalytic synthesis of strained carbocycles 发明人:CHEN KAI; HUANG XIONGYI; KAN S B JENNIFER 权利人:CALIFORNIA INST OF TECHN 摘要:Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.
专利号:US-11920040-B2 优先权日:2018-05-29 标 题 :Carborhodamine compounds and methods of preparation thereof 发明人:LUKHTANOV EUGENY A 权利人:ELITECHGROUP MDX LLC 摘要:The carborhodamine dyes disclosed herein are novel reagents suitable for automated incorporation of carborhodamine dyes into oligonucleotides that can be used in detection methods for nucleic acid targets. This disclosure provides an efficient and simple process for the preparation of carborhodamine compounds and introduces previously unknown reagents for the automated synthesis of oligonucleotide-carborhodamine conjugates.
专利号:US-2022389049-A1 优先权日:2019-10-04 标 题:Reversible terminators for dna sequencing and methods of using the same 发明人:JAIN MOTI; ZHOU WEI 权利人:CENTRILLION TECH INC 摘要:The present disclosure provides methods of sequencing polynucleotides and compounds, compositions for sequencing of polynucleotides, and synthesis of such compositions. The chemical compounds include nucleotides and their analogs which possess a sugar moiety comprising a cleavable chemical group capping the 3′-OH group and a base, but without covalently bounded dye. The cleavable chemical group is reactive to form covalent bond(s) with a dye used to confirm the presence of the expected base-pairing. The cleavable chemical group capping the 3′OH group can be removed together with the covalently bounded dye. Furthermore, after the cleavable chemical group is cleaved, the free 3′-OH group can be active in continued elongation. Example chemical compounds according to the present disclosure are shown as Formulas (II) and (V):
专利号:US-9006345-B2 优先权日:2011-03-25 标题 :Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials 发明人:LANCASTER JEFFREY; KOBERSTEIN JEFFREY T; TURRO NICHOLAS J 权利人:LANCASTER JEFFREY; KOBERSTEIN JEFFREY T; TURRO NICHOLAS J; UNIV COLUMBIA 摘要:In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches.
摘要:Aguilar, E.; López, L. A., Science of Synthesis Knowledge Updates, (2014) 2, 31. 摘要:Clark, R. W.; Wiskur, S. L., Science of Synthesis Knowledge Updates, (2015) 1, 16. 摘要:Yoshida, H., Science of Synthesis Knowledge Updates, (2022) 3, 3. 摘要:Durand, A.; Hemeon, I.; Singer, R. D., Science of Synthesis Knowledge Updates, (2013) 2, 144. 摘要:Hlina, J. A., Science of Synthesis Knowledge Updates, (2021) 1, 127.