CAS: 537705-08-1; 2-Methoxy-N-[3-[4-[[3-Methyl-4-[(6-Methylpyridin-3-yl)Oxy]Phenyl]Amino]Quinazolin-6-Yl]Allyl]Acetamide
该化合物是一种合成有机化合物,其结构复杂,包括多种功能组,如甲基氧,乙酰胺和quinazoline moices.该化合物通常因其潜在的生物活动而进行研究,特别是在医学化学领域,在那里可能表现出癌症治疗或其他治疗领域的特性.
- 英文名称2-Methoxy-N-[3-[4-[[3-Methyl-4-[(6-Methylpyridin-3-yl)Oxy]Phenyl]Amino]Quinazolin-6-Yl]Allyl]Acetamide
- 中文名称2-甲氧基-N-[3-[4-[[3-甲基-4-[(6-甲基-3-吡啶基)氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯-1-基]乙酰胺
- IUPAC名称2-methoxy-N-(3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)amino)quinazolin-6-yl)allyl)acetamide
- 其它别名(E)-2-Methoxy-N-(3-(4-(3-Methyl-4-(6-Methylpyridin-3-Yloxy)Phenylamino)Quinazolin-6-yl)Allyl)Acetamide; 2-Methoxy-N-[3-[4-[[3-Methyl-4-[(6-Methyl-3-Pyridinyl)Oxy]Phenyl]Amino]-6-Quinazolinyl]-2-Propen-1-Yl]Acetamide
- CAS编号537705-08-1
- MFCD编号:MFCD19687281
- 分子式:C27H27N5O3分子量:469.55
- 产品CID: 1520760
- 产品分类生物化工 → 抑制剂 → 蛋白酪氨酸激酶
物理性质
- 沸点687.3±55.0 °C at 760 mmHg
- 闪点369.5±31.5 °C
- 密度1.3±0.1 g/cm3
- PSA:98.26
- LogP:4.05
- 折射率1.663
- 蒸汽压0.0±2.1 mmHg at 25°C
- 溶解性≥23.5 mg/mL in DMSO; insoluble in H2O; ≥25.4 mg/mL in EtOH
- 外观形态固体
- 储存条件-20°C
- 产品应用该化合物是一种强效和选择性的HER2/ERBBB2抑制剂,在无细胞试验中,IC50为10纳米的IC50, 其浓度为10 NM,表明对EGFR,INSR,IGF-1R,PDGFFR, VEG FR2,ABL,SRC和C-MET的选择性选择超过640倍,表明其具有640个以上的选择性,在EGFFR, INSR, IGFI-1R, PDG-R, PDFFFER, VEEG-FR2, ABL, SRC, 和CM-MT, C-M, 限制其扩散.BT-474和SKBR3等强化的癌症细胞,如BT-474和SKBRR3, 分别具有0.25 ΜM和0.95 Μ M.在活性反应值分别为50毫克/千克的体内,CP-74714在蒸射线上显示其抗和取得50%的肿瘤抑制剂的细胞抑制剂在FREB2号中出现了50%的磁部下产生50%的抑制剂抑制剂.
上下游产品
Methoxyacetyl chloride 6-iodo-N-(3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)quinazolin-4-amine N-propargyl-2-methoxyacetamide 5-Hydroxy-2-methylpyridine合成工艺路线路线简述
📜6-碘-N-(3-甲基-4-((6-甲基吡啶-3-基)氧基)苯基)喹唑啉-4-胺,Palladium Diacetate置于potassium Carbonate,三苯基膦体系中,用 水,乙酸乙酯 作为反应溶剂,化学反应生成 2-甲氧基-N-[3-[4-[[3-甲基-4-[(6-甲基-3-吡啶基)氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯-1-基]乙酰胺
参考文献:Processes For The Preparation Of Substituted Bicyclic Derivatives For The Treatment Of Abnormal Cell Growth
标题:Processes For The Preparation Of Substituted Bicyclic Derivatives For The Treatment Of Abnormal Cell Growth
摘要:本发明涉及制备式11化合物的过程,以及其药学上可接受的盐,前药和溶剂化物,其中r1,R3,R4,R5,R11,M和p的定义如本文所述.式1化合物在哺乳动物中通过给予药物组成物来治疗异常细胞生长.
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902300000-甲苯
2902500000-苯乙烯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2005192298-A1
优先权日:2004-02-27
标 题 :Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide
发明人：LI ZHENG J; LEONARD JASON A
权利人:PFIZER
摘要:Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide. A crystal form is useful in the synthesis of salts and complexes of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide. A crystal form also improves stability of tabletted or capsuled E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide as a drug product.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
📝 需求与反馈
尽可能描述清楚需求与问题信息
