CAS: 52665-69-7; Ionophore A23187

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📜顺式-3,5-二甲基环己酮置于1,3-丙二硫醇,盐酸,Bis(Cyclohexyl)Aminomagnesium Bromide,三氟化硼乙醚,Sodium Methylate,Sodium Hydride,Lithium Thiopropiolate,对甲苯磺酸,臭氧,Magnesium,溶剂黄146,间氯过氧苯甲酸,Pyridinium Chlorochromate,Copper(II) Oxide,Copper Dichloride,锌体系中,用 甲醇,六甲基磷酰三胺,乙醚,二氯甲烷,苯 作为反应溶剂,化学反应生成 离子载体
参考文献:聚醚抗生素(-)-A23187(钙霉素)的全合成
标题:聚醚抗生素(-)-A23187(钙霉素)的全合成
摘要:(-)-A23187(钙霉素)的总合成通过收敛方法完成.合成的关键步骤是在碱性条件下将β-羟基酮立体定向环化成螺酮.
DOI:10.1016/s0040-4039(00)95911-2

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-4814347-A
优先权日:1985-07-22
标 题:Anthelmintic spiroketals and method of use
发明人：NELSON STEPHEN J
权利人:UPJOHN CO
摘要:This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.

专利号:US-6177572-B1
优先权日:1997-08-20
标题 :Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use
发明人：WANG FENGJIANG
权利人:SEPRACOR INC
摘要:Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.

专利号:WO-2008058514-A1
优先权日:2006-11-14
标 题:Preparations comprising boswellic acids for inhibiting the synthesis of prostaglandin e2
发明人：WERZ OLIVER; SIEMONEIT ULF
权利人:UNIV EBERHARD KARLS; WERZ OLIVER; SIEMONEIT ULF
摘要:The present invention relates to the use of preparations with pentacyclic triterpenoic acids and structural derivatives thereof, in particular boswellic acids from Boswellia species (such as B. serrata, B. carterii, B. sacra), for inhibiting the inducible mitochondrial prostaglandin E₂ synthase-1. In addition, the invention relates to the use of pentacyclic triterpenoic acids and derivatives thereof for producing a medicament for the treatment of PGE₂-mediated diseases.

专利号:US-4686297-A
优先权日:1985-07-22
标 题 :Anthelmintic spiroketals useful for killing parasitic worms
发明人：NELSON STEPHEN J
权利人:UPJOHN CO
摘要:This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.

专利号:US-4680419-A
优先权日:1985-07-22
标题:Spiroketals and process for preparing same
发明人：NELSON STEPHEN J
权利人:UPJOHN CO
摘要:This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.