CAS: 52328-96-8; (1E,4Z,6E)-5-Hydroxy-1,7-Bis(4-Hydroxyphenyl)Hepta-1,4,6-Trien-3-One

上下游产品

4-hydroxy-benzaldehyde acetylacetone 4-formylphenyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside benzaldehydeAcetic acid 4-[(1E,3Z,6E)-7-(4-acetoxy-phenyl)-3-hydroxy-5-oxo-hepta-1,3,6-trienyl]-phenyl ester (+/-)-5-hydroxy-1,7-bis-(4'-hydroxyphenyl)-3-heptanone 1,7-bis(4-hydroxyphenyl)heptane-3,5-dione 1E,6E-1,7-bis(4-methoxyphenyl)hepta-1,6-diene-3,5-dione

📜乙酰丙酮置于盐酸,Boron Trioxide,硼酸三丁酯,正丁胺体系中,化学反应生成 (Z,E,E)-5-羟基-1,7-二(4-羟基苯基)-1,4,6-庚三烯-3-酮
参考文献:A Comparative Study On The Antioxidant Properties Of Tetrahydrocurcuminoids And Curcuminoids
标题:A Comparative Study On The Antioxidant Properties Of Tetrahydrocurcuminoids And Curcuminoids
摘要:Several Curcuminoids And Tetrahydrocurcuminoids (Thcs),Bearing Various Hydroxyl And/or Methoxy Groups On Their Benzene Rings,Have Been Synthesized To Study Their Antioxidant And Hydrogen Donating Capacities Using The Dpph Method At 25 Degrees C In Methanol. The Results Show That The Tetrahydrocurcuminoids Are In General Much More Efficient Than Their Curcuminoid Analogs If They Include A Phenol Group In Meta-Or Para-Position Of The Linking Chain And A Neighboring Phenol Or Methoxy Group. This Efficiency Gain Of Thcs By Comparison To Curcuminoids Was Attributed To The Presence Of Benzylic Hydrogens Involved In The Oxidation Process Of These Compounds And Not To The Beta-Diketone Moiety In The Chain. (C) 2007 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tet.2007.06.085

专利信息

专利号:US-7507864-B2
优先权日:2006-08-01
标题:Method for the synthesis of curcumin analogues
发明人：MILLER JEFFREY CHRISTOPHER; MITCHELL MIGUEL O
权利人:SALISBURY UNIVERSITY
摘要:The present invention relates to improved methods for achieving the synthesis of 1,7-diaryl-1,6-heptadiene-3,5-diones, and in particular curcumin and its analogues. The invention provides a process for synthesizing such compounds in substantial yield and purity using environmentally benign processes and materials. The invention also relates to the use of such synthesized products in the treatment of Alzheimer's Disease and other diseases.

专利号:US-2008033055-A1
优先权日:2006-08-01
标题 :Method for the Synthesis of Curcumin Analogues