CAS: 4730-54-5; 1,4,7-Triazacyclononane

相似化合物

58966-93-1 52667-89-7 125262-43-3

上下游产品

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N,N',N''-Tris(β-Trimethylsilylethanesulfonyl)-1,4,7-Triazacyclononane置于cesium Fluoride体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 24.0H,以68%的收率获得产物1,4,7-三氮杂环壬烷
参考文献:通过β-三甲基甲硅烷基乙烷磺酰胺的改性richman-Atkins环化合成聚氮杂大环化合物.
标题:通过β-三甲基甲硅烷基乙烷磺酰胺的改性richman-Atkins环化合成聚氮杂大环化合物.
摘要:Richman-Atkins环化仍然是制备大环多胺的最广泛使用的方法之一.描述了β-三甲基甲硅烷基乙烷磺酰胺(ses-磺酰胺)在制备聚氮杂大环化合物中的用途.这扩展了现有的richman-Atkins磺酰胺大环化方法,并成功地实现了不稳定的聚氮杂[n](1,4)萘甲酸酯和聚氮杂[n](9,10)蒽甲酚的制备,以前没有大量使用.
DOI:10.1021/jo001639O

专利信息

专利号:WO-2012003598-A1
优先权日:2010-07-06
标 题 :Intermediates for the synthesis of 1,2-bis(4,7-dimethyl-1,4,7-triazacyclonon-1-yl)-ethane and preparation method thereof
发明人：HAGE RONALD; KOEK JEAN HYPOLITES; RUSSELL STEPHEN WILLIAM; WANG XIAOHONG; WOLF LODEWIJK VAN DER; ZHANG JIANRONG; ZHAO WEI
权利人:UNILEVER PLC; UNILEVER NV; UNILEVER HINDUSTAN; HAGE RONALD; KOEK JEAN HYPOLITES; RUSSELL STEPHEN WILLIAM; WANG XIAOHONG; WOLF LODEWIJK VAN DER; ZHANG JIANRONG; ZHAO WEI
摘要:The present invention provides intermediates for the synthesis of 1,2-bis(4,7-dimethyl-1,4,7-triazacyclonon-1-yl)-ethane and preparation method thereof. The intermediates are protonated salts of 1,4-ditosylate-1,4,7-triazacyclononane or 1,4-dibenzenesulphonate-1,4,7-triazacyclononane. The preparation method of 1,4-diarylsulfonate-1,4,7-triazacyclononane (compound A) comprises reacting 1,4,7-triarylsulfonate-1,4,7-triazacyclononane (compound B) in an acidic medium comprising sulphuric acid, wherein the molar ratio of B to sulphuric acid is in the range from 1 : 0.5 to 1 : 10, or reacting 1,4,7-triarylsulfonate-1,4,7-triazacyclononane (compound B) in an acidic medium and working up the acidic medium when the conversion of B to A is at least 50 mol % yielding compound A.

专利号:US-8907082-B2
优先权日:2010-07-06
标 题 :1,2-bis-(4,7-dimethyl-1,4,7-triazacyclonon-1-yl)-ethane and intermediate for the synthesis of same
发明人：HAGE RONALD; KOEK JEAN HYPOLITES; RUSSELL STEPHEN WILLIAM; VAN DER WOLF LODEWIJK; ZHANG JIANRONG; ZHAO WEI; WANG XIAOHONG
权利人:HAGE RONALD; KOEK JEAN HYPOLITES; RUSSELL STEPHEN WILLIAM; VAN DER WOLF LODEWIJK; ZHANG JIANRONG; ZHAO WEI; WANG XIAOHONG; CATEXEL LTD
摘要:The present invention provides improved processes for the synthesis of 1,4-ditosyl-1,4,7-triazacyclonone, comprising deprotecting a compound of formula (C): n nwherein P is tosylate or arylsulfonate, with an acidic medium to form 1,2-bis(1,4,7-triazacyclonon-1-yl)-ethane; and subsequently adding formaldehyde and formic acid to the acidic medium to form 1,2-bis-(4,7-dimethyl-1,4,7-triazacyclonon-1-yl)-ethane (Me 4 -DTNE). The syntheses of intermediates are also disclosed.

专利号:US-9988388-B2
优先权日:2012-11-21
标 题:Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C- functionalized derivatives thereof
发明人：DENAT FRANCK; DESOGERE PAULINE; BERNHARD CLAIRE; ROUSSELIN YOANN; BOSCHETTI FREDERIC
权利人:UNIV BOURGOGNE; CENTRE NAT RECH SCIENT
摘要:A compound with formula (V′) n nthe synthesis method for compound (V′), and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I)n n nAlso, metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.

专利号:WO-2025088147-A1
优先权日:2023-10-27
标题 :Theranostic psma-targeting ligands for the diagnosis and treatment of psma-expressing cancers and their solid phase synthesis
发明人：Schäfer Martin; BAUDER-WUEST ULRIKE; ROSCHER MAREIKE; REMDE YVONNE; BENEÅ OVà -SCHÄFER MARTINA; BARINKA CYRIL; KUTILOVà ZSÓFIA; MOTLOVà LUCIA
权利人:DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS
摘要:The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and radiopharmaceuticals for the treatment of various disease states of PSMA-expressing cancers, especially prostate cancer, and metastases thereof. Further the present invention provides synthetic procedures for the synthesis of such PSMA-targeting ligands.

专利号:US-2025049714-A1
优先权日:2021-12-09
标题 :Synthesis of ester, carbonate, and carbamate-derived novel biodegradable ionizable lipids from methyl ricinoleate or methyl 12-hydroxystearate and its applications
发明人：ANDERSON DANIEL GRIFFITH; RHYM LUKE HYUNSIK; LI BOWEN; GORDON AKIVA; RAJITH SINGH MANAN; WITTEN JACOB
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).

专利号:US-2025313580-A1
优先权日:2022-05-19
标题 :Synthesis of fluorosilyl compounds
发明人：FORD THONAN LEE; THOMAS ALEXANDER JAMES FLOY; RAHMAN SABITUR
权利人:BLUE EARTH THERAPEUTICS LTD
摘要:The disclosures herein relate to methods of synthesising a compound of formula (1): n n n n n n n n n n wherein PG, R 2 and R 3 are as defined herein, and the use of said methods in the manufacture of conjugates that bind to PSMA.