专利号:US-7777023-B2 优先权日:1998-10-23 标题 :Method for the chemical synthesis of oligonucleotides 发明人:VARGEESE CHANDRA; SHAFFER CHRISTOPHER; WANG WEIMIN 权利人:SIRNA THERAPEUTICS INC 摘要:The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof.
专利号:US-5447709-A 优先权日:1992-10-26 标题:Process for the synthesis of zeolites belonging to the faujasite structural family 发明人:ANGLEROT DIDIER; FERON BEATRICE; GUTH JEAN-LOUIS 权利人:ELF AQUITAINE 摘要:Process for the synthesis of faujasite, having a Si/Al ratio greater than 1 and which can exceed 3, in the presence of a structuring agent consisting of at least one carbonaceous macrocycle having 10 to 24 atoms per ring and containing heteroatoms chosen from oxygen, nitrogen, sulphur or silicon, the macrocycle being introduced into the reaction medium in the form of a crude synthetic sodium complex.
专利号:US-2024400533-A1 优先权日:2023-06-02 标题 :General Solid-Phase Synthesis of Crown Ethers 发明人:TRANT JOHN F; NASRI SARAH; HAYWARD JOHN J 权利人:UNIV OF WINDSOR 摘要:In a preferred embodiment, there is provided a method for preparing a crown ether, the method comprising: loading a resin having a resin functional group with a linking compound having a functional group selected for coupling to the resin functional group and at least two carbon atoms each having a substituent; coupling the linking compound to a polyethylene glycol having two terminal carbon atoms each bonded to an optionally protected terminal hydroxyl group to obtain a cyclized intermediate, whereby one said at least two carbon atoms or the substituent and an associated one of the two terminal carbon atoms or the hydroxyl groups undergo a coupling or substitution reaction; and removing the linking compound and the cyclized intermediate from the resin.
专利号:US-7205399-B1 优先权日:2001-07-06 标 题 :Methods and reagents for oligonucleotide synthesis 发明人:VARGEESE CHANDRA; WANG WEIMIN 权利人:SIRNA THERAPEUTICS INC 摘要:The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof.
专利号:US-7658868-B2 优先权日:2002-03-20 标 题 :Molecular actuators, and methods of use thereof 发明人:ANQUETIL PATRICK A; HUNTER IAN W; MADDEN JOHN D; MADDEN PETER G; PULLEN ANTHONY E; SWAGER TIMOTHY M; XU BING; YU HSIAO-HUA 权利人:MASSACHUSETTS INST TECHNOLOGY; US NAVY 摘要:The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from Ï€-Ï€ stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.
专利号:US-2006036090-A1 优先权日:1998-10-23 标题:Method for the chemical synthesis of oligonucleotides
[参考文献]: An S, Et Al. Small-Molecule Protacs: An Emerging And Promising Approach For The Development Of Targeted Therapy Drugs. Ebiomedicine. 2018 Oct;36:553-562. [参考文献]: Daniel Collado, Et Al. Bis(Isoquinoline N-Oxide) Pincers As A New Type Of Metal Cation Dual Channel Fluorosensor. Org Lett. 2002 Mar 7;4(5):855-8.
合成参考文献
摘要:Haino, T.; Iwamoto, H., Science of Synthesis, (2010) 45, 1210.