CAS: 3102-56-5; Rel-(2R,3S)-2-Aminooctadecane-1,3-Diol

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CAS号764-22-7 D-赤式-二氢鞘氨醇

📜D-赤式-二氢-D-鞘氨醇 反应生成 L-苏式-二氢鞘胺醇
参考文献:Sticht Et Al.,1972,Vol. 8,P. 10,21
标题:Sticht Et Al.,1972,Vol. 8,P. 10,21

专利信息

专利号:US-6440703-B1
优先权日:1997-12-01
标 题 :Enzymatic synthesis of gangliosides
发明人：DEFREES SHAWN
权利人:NEOSE TECHNOLOGIES INC
摘要:This invention provides methods for practical in vitro synthesis of gangliosides and other glycolipids. The synthetic methods typically involve enzymatic synthesis, or a combination of enzymatic and chemical synthesis. One or more of the enzymatic steps is preferably carried out in the presence of an organic solvent.

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-5262312-A
优先权日:1990-04-25
标 题:Process for the glycosidase-catalyzed synthesis of glyco conjugates
发明人：HOLLA WOLFGANG; SCHUDOK MANFRED
权利人:HOECHST AG
摘要:It has been possible to show for a first time with the process according to the invention that the synthesis of glyco conjugates is possible by direct linkage of sugars with serine, serine derivatives and serine peptides with the aid of glucosidases.

专利号:US-2005182020-A1
优先权日:2003-11-14
标题 :Ceramide de novo synthesis-based therapeutic and prophylactic methods, and related articles of manufacture
发明人：WORGALL TILLA S; DECKELBAUM RICHARD J
摘要:Described is a method for decreasing the amount of mSREBP in a cell characterized by an elevated level of mSREBP comprising contacting the cell with an agent that specifically inhibits de novo synthesis of ceramide in the cell, thereby decreasing the amount of mSREBP in the cell. Also described are related methods and articles of manufacture.

专利号:US-5220043-A
优先权日:1991-03-21
标 题:Synthesis of D-erythro-sphingomyelins
发明人：DONG ZHENGXIN; BUTCHER JR JARED A
权利人:UNIV OHIO
摘要:A method for making optically pure D-erythro-sphingomyelins which may be labeled for identification and testing purposes is provided. The present method is directed to a five step synthesis comprising the steps of: (1) reacting a (2S,3R,4E)-2-azido-octadecen-1,3-diol composition having a protective functional group attached thereto with a solution of triphenylphosphine and water in a first solvent to form a protected sphingosine; (2) reacting a long-chain fatty acid with the protected sphingosine in the presence of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline catalyst in a second solvent to form a protected ceramide; (3) reacting 2-chloro-2-oxo-1,3,2-dioxaphospholane with the protected ceramide in the presence of triethylamine and 4-dimethylaminopyridine catalyst in a third solvent to form a protected cyclic phosphotriester; (4) reacting trimethylamine with the protected cyclic phosphotriester in a solvent system to form a protected sphingomyelin; and (5) reacting tetra-n-butylammonium fluoride with the protected sphingomyelin in tetrahydrofuran to form the D-erythro-sphingomyelin composition.