CAS: 29745-04-8; Rel-(3Ar,4R,7S,7As)-Hexahydro-4,7-Epoxyisobenzofuran-1,3-Dione

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6118-51-0 5426-09-5 1164475-59-5

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📜Exo-3,6-Epoxy-1,2,3,6-Tetrahydrophthalic Anhydride 在 Palladium 10% On Activated Carbon,氢气体系中,用 丙酮作为反应溶剂,50.0 °C,5.0 Mpa 条件下,以100%的收率获得norcantharidin
参考文献:A Flow Chemistry Approach To Norcantharidin Analogues
标题:A Flow Chemistry Approach To Norcantharidin Analogues
摘要:利用 Thalesnano H-Cube™ 流动氢化器,采用 "一步法 "合成程序制备了酸酯和酸酰胺去甲蒽啶衍生物.传统上,这些类似物的快速库生成和反应放大受到 5,6-Dehydronorcantharidin批量氢化的限制.使用流动化学方法解决了这一问题.由于不存在相关的放大问题,我们设计出了一种方法,可以在生物筛选所需的任何规模上生产去甲蒽啶以及酸酯和酸酰胺类似物.
Doi:10.2174/157018011795906730

专利信息

专利号:US-8835658-B2
优先权日:2012-12-28
标 题:Asymmetric synthesis of norcantharidin analougus by alkynylation of oxabenzonorbornadienes and their anticancer activities
发明人：CHAN ALBERT SUN-CHI; FAN BAOMIN; WANG JUN; LIN CHENGYUAN; HUANG CHAO; YANG QINGJING; XU JIANBIN; BIAN ZHAOXIANG; LU AIPING; HU JUN
权利人:UNIV HONG KONG BAPTIST; UNIV YUNNAN NATIONALITIES
摘要:The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.

专利号:US-6110907-A
优先权日:1997-04-30
标题 :Synthesis of platinum complexes and uses thereof
发明人：AU-YEUNG STEVE C F; HO YEE PING; GE LIN; XIUWEN HAN; XINNING WANG; SHIWEI LU; TAO JIANG
权利人:DALIAN CHEMICAL PHYSICS INST; UNIV HONG KONG CHINESE
摘要:This invention provides novel antitumor demethylcantharidin platinum complexes. This invention also provides a composition comprising at least one of said demethylcantharidin platinum complexes and a suitable carrier. This invention provides a pharmaceutical composition comprising effective amount of at least one of the said demethylcantharidin platinum complexes and a pharmaceutically acceptable carrier. This invention provides a method of inhibiting the growth of tumorous cells comprising contacting the cells with an amount of said demethylcantharidin platinum complex effective to inhibit the growth of said tumorous cells. This invention provides a method of inhibiting the growth of tumorous cells in a subject comprising administering to the subject with an amount of the said demethylcantharidin platinum complexes effective to inhibit the growth of said tumorous cells in the subject. Finally, this invention provides methods for producing said demethylcantharidin platinum complexes.

专利号:US-12201669-B2
优先权日:2021-03-11
标 题:Small molecule suppressors of APOE gene expression and cerebral vascular amyloid pathology
发明人：TSAI LI-HUEI; BLANCHARD JOEL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present disclosure provides methods of inhibiting amyloid synthesis in a subject using small molecule inhibitors. The invention also includes methods of treating disease associated with amyloid synthesis, such as Alzheimer's disease. The small molecule inhibitors disclosed herein are compounds which are non-immunosuppressant cyclosporin including the pharmaceutically acceptable salts thereof.

专利号:CN-115353522-A
优先权日:2022-08-22
标 题:Regioselective Synthesis of Icaritin-Norcantharidin Conjugate and Its Antitumor Application

专利号:WO-9849174-A1
优先权日:1997-04-30
标 题:Synthesis of platinum complexes and uses thereof

专利号:CN-111303179-A
优先权日:2020-03-17
标 题:Synthesis of a Class of Norcantharidin Carboxylic Acid Difluorobenzyl Esters and Its Antitumor Application