专利号:US-6770436-B1 优先权日:1996-11-14 标题:Chemical amplification for the synthesis of patterned arrays 发明人:BEECHER JODY E; GOLDBERG MARTIN J; MCGALL GLENN H 权利人:AFFYMETRIX INC 摘要:Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
专利号:US-2004110133-A1 优先权日:2002-12-06 标 题 :Functionated photoacid generator for biological microarray synthesis 发明人:XU GUANGYU; GOLDBERG MARTIN 权利人:AFFYMETRIX INC 摘要:In some embodiment of the invention, methods are provided for the synthesis of polymer arrays. In one embodiment, a chemically amplified polymer matrix is used for the synthesis of polymer arrays.
专利号:US-7053198-B2 优先权日:2002-12-06 标题 :Functionated photoacid generator and functionated polymer system for biological microarray synthesis 发明人:GOLDBERG MARTIN; XU GUANGYU 权利人:AFFYMETRIX INC 摘要:In some embodiment of the invention, methods are provided for the synthesis of polymer arrays. In one embodiment, a reactive polymer and a photo acid generator is used for the photodirected polymer array synthesis.
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-2025049730-A1 优先权日:2021-11-24 标 题:Ultra small gelatin nanoparticles, composite structures and synthesis method 发明人:KANNAN RAGHURAMAN; Suresh Dhananjay 权利人:UNIV MISSOURI 摘要:A method for synthesizing ultrasmall gelatin nanoparticles. A first desolvation is conducted to produce gelatin strands in a first solution and then setting the pH of the solution to charge and separate the strands. Tripolyphosphate (TPP) is added to the first solution to form gelatin-TPP-gelatin bridges. Second desolvation of the gelatin-TPP-gelatin bridges is conducted in a second solution. The second solution contains an TPP-Ethanol:Acetone mixture in a ratio between 1:1 and 1:5 and TPP between 0.005-0.025 vol % or a Glutaraldehyde-Ethanol:Acetone mixture in a ratio of glutaraldehyde-ethanol:Acetone range of 2.5-12% v/v to produce a colloid of self-assembled gelatin nanoparticles. The method can produce nanomaterial consisting of a plurality of gelatin nanoparticles sized at Ëœ10 nm. The nanomaterial can encapsulate a drug, metal nanoparticle or contrast agent.
专利号:US-11618777-B2 优先权日:2015-07-31 标 题 :Method of manufacturing membrane protein and utilization thereof 发明人:YOKOYAMA SHIGEYUKI; SHINODA TAKEHIRO; ITO KAORI; NOMURA NAOKO; KATSURA YOSHIKO; SOMEYA TOMOMI; SHIROUZU MIKAKO; HORI TETSUYA; NAKAMURA YOSHIHIRO; TANABE HIROAKI 权利人:YOKOYAMA SHIGEYUKI 摘要:In order to provide a membrane protein production method which does not require the step of solubilizing a membrane protein and which allows the membrane protein having an excellent quality to be obtained with a high yield, a method in accordance with an embodiment of the present invention includes: a step (a) of preparing a reaction solution for cell-free protein synthesis, the reaction solution containing (i) a template nucleic acid which encodes the membrane protein, (ii) a lipid, and (iii) a detergent which is contained at a concentration equal to or higher than a critical micelle concentration; and a step (b) of synthesizing the membrane protein while the concentration of the detergent in the reaction solution is maintained at a concentration equal to or higher than a critical micelle concentration.
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合成参考文献
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