CAS: 182359-60-0; 3-Hydroxy-N-(2-Oxotetrahydrofuran-3-yl)Dodecanamide

主要参考文献

参考标题:Methods Of Treating Or Preventing An Infectious Disease Using An Immunogenic Conjugate Of A Gram-Negative Bacterial Autoinducer Molecule Or Antibodies That Immunospecifically Bind A Gram-Negative Bacterial Autoinducer Molecule
摘要:The Present Invention Relates To An Immunogenic Conjugate Comprising A Carrier Molecule Coupled To An Autoinducer Of A Gram Negative Bacteria The Immunogenic Conjugate, When Combined With A Pharmaceutically Acceptable Carrier, Forms A Suitable Vaccine For Mammals To Prevent Infection By The Gram Negative Bacteria The Immunogenic Conjugate Is Also Used To Raise And Subsequently Isolate Antibodies Or Binding Portions Thereof Which Are Capable Of Recognizing And Binding To The Autoinducer. The Antibodies Or Binding Portions Thereof Are Utilized In A Method Of Treating Infections, A Method Of Inhibiting Autoinducer Activity, And In Diagnostic Assays Which Detect The Presence Of Autoinducers Or Autoinducer Antagonists In Fluid Or Tissue Samples. Table Of Contents Page 1. Field Of The Invention 1 2. Background Of The Invention 1 3. Summary Of The Invention 4 4. Brief Description Of The Drawings 7 5. Detailed Description Of The Invention 7 5.1 Isolation And Synthesis Of Homoserine Lactones 7 5.2 Bacterial Autoinducer Conjugation To A Carrier 17 5.3 Generation Of Antibodies To Bai Immunogenic Conjugates 19 5.4 Therapeutic Uses Of Immunogenic Conjugates 22 Or Antibodies Thereto 5.4.1 Administration And Formulation 22 5.4.2 Effective Dose 25 5.5 Diagnostic Methods 27 6. Example: Synthesis 32 Preparation Of Compound C 32 Preparation Of Compound D 32 Preparation Of Compound 5 32 Preparation Of Compound 6 33 Preparation Of Compound 7 33 Preparation Of Compound 8 33 Preparation Of Compound 10 34 Preparation Of Compound 11 34 Preparation Of Compound 13 35 Preparation Of Compound 12 35 Preparation Of Compound 14 35 Preparation Of Compound 15 36 Preparation Of Compound 17 36 Preparation Of Compound 21 37 Preparation Of Compound 22 37 Preparation Of Compound 24 38 Preparation Of Compound 25 38 Preparation Of Compound 27 38 Preparation Of Compound 29 39 7. Example: Production Of Bai Antibodies 39 7.1 Pai'S Role In Virulence 39 7.2 Anti-Pai Polyclonal Antibodies 40 7.3 Neutralization Of Pai With Antibodies 40

合成参考文献

合成方法参考DOI号:10.1021/jm2001019