CAS: 1404453-75-3; Tetrahydrofuran-3-Yl 2-Cyclopentyl-2-Hydroxy-2-Phenylacetate
- 相似结构搜索
- InChIKey: ZOTRQGHPFBTLJO-UHFFFAOYSA-N
- 计算化学: 氢键受体数4.0氢键供体数1.0可旋转键数4.0
物理性质
MSDS等安全信息
上下游产品
2-环戊基-2-羟基苯乙酸 2-Cyclopentyl-2-Hydroxy-2-Phenylacetic Acid 427-49-6合成工艺路线路线简述
📜2-环戊基-2-羟基苯乙酸甲酯置于n,N'-羰基二咪唑,Sodium Hydroxide体系中,用 甲醇,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 0.5H,反应生成格隆溴铵杂质1
参考文献:Carry Over Of Impurities: A Detailed Exemplification For Glycopyrrolate (Nva237)
标题:Carry Over Of Impurities: A Detailed Exemplification For Glycopyrrolate (Nva237)
摘要:The Original Synthesis Of Glycopyrrolate (Nva237) Was Revised And Shortened Into An Essentially One-Pot Process. Without Isolating The Intermediates,Their Purification Became Obsolete,Thereby Increasing The Possibility Of The Carry Over Of Impurities. For That Reason,The Actual,Potential,And Theoretical Impurities Of The Starting Materials Cyclopentyl Mandelic Acid And 1-Methyl-Pyrrolidin-3-Ol As Well As Byproducts Which May occur During The Synthesis Were Thoroughly Investigated; Furthermore,Their Transformation To Possible Impurities In The Drug Substance Along The New Synthetic Route Was Performed To Exclude Them As Actual Impurities In The Drug Substance With Certainty. The Question Is Raised How Detailed Such Investigation-Which Are Fairly Manageable For A Simple Product Like Glycopyrrolate-Need To Be.
Doi:10.1021/op3001788
参考文献:Carry Over Of Impurities: A Detailed Exemplification For Glycopyrrolate (Nva237)
标题:Carry Over Of Impurities: A Detailed Exemplification For Glycopyrrolate (Nva237)
摘要:The Original Synthesis Of Glycopyrrolate (Nva237) Was Revised And Shortened Into An Essentially One-Pot Process. Without Isolating The Intermediates,Their Purification Became Obsolete,Thereby Increasing The Possibility Of The Carry Over Of Impurities. For That Reason,The Actual,Potential,And Theoretical Impurities Of The Starting Materials Cyclopentyl Mandelic Acid And 1-Methyl-Pyrrolidin-3-Ol As Well As Byproducts Which May occur During The Synthesis Were Thoroughly Investigated; Furthermore,Their Transformation To Possible Impurities In The Drug Substance Along The New Synthetic Route Was Performed To Exclude Them As Actual Impurities In The Drug Substance With Certainty. The Question Is Raised How Detailed Such Investigation-Which Are Fairly Manageable For A Simple Product Like Glycopyrrolate-Need To Be.
Doi:10.1021/op3001788
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
合成方法参考DOI号:10.1021/op3001788
📝 需求与反馈
尽可能描述清楚需求与问题信息
