CAS: 13242-44-9; 2-(N,N-Dimethylamino)Ethylthiol Hydrochloride

上下游产品

(2-chloroethyl)dimethylamine hydr°Chloride N-Benzyl-dithi°Carbaminsaeure-(2-dimethylamino-ethylester) 3-(2-Dimethylamino-aethylmercapto)-rifamycin SV b,f]thiepin-10-ylsulfanyl)-ethyl]-dimethyl-amine[2-(8-chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-ylsulfanyl)-ethyl]-dimethyl-amine Dimethyl-[2-(7-methyl-3-phenyl-quinolin-2-ylsulfanyl)-ethyl]-amine

二甲氨基氯乙烷盐酸置于sodium Thiosulfate,盐酸体系中,用 水 用作溶剂,化学反应 12.0H,反应生成2-甲胺乙硫醇盐酸盐
参考文献:Facile Conversion Of Cysteine And Alkyl Cysteines To Dehydroalanine On Protein Surfaces: Versatile And Switchable Access To Functionalized Proteins
标题:Facile Conversion Of Cysteine And Alkyl Cysteines To Dehydroalanine On Protein Surfaces: Versatile And Switchable Access To Functionalized Proteins
摘要:An Efficient And Robust Oxidative Elimination Of Cysteine To Dehydroalanine Has Been Discovered. The Reaction Is Induced By O-Mesitylenesulfonylhydroxylamine (Msh) And Is Compatible With Methionine. The Key Elimination Has Been Executed On Protein Surfaces And Allows Ready Access To Different Post-Translationally Modified Proteins Through Conjugate Addition Of Sulfur Nucleophiles To Dehydroalanine. Treatment Of The Resulting Thioether With Msh Results In Regeneration Of Dehydroalanine,Allowing A "Functional Switch" By Subsequent Addition Of A Different Thiol.
Doi:10.1021/ja800800P

专利信息

专利号:US-5304647-A
优先权日:1988-02-09
标题:Method of preparation of halogenated diazines
发明人：STREKOWSKI LUCJAN; MOKROSZ MARIA; HARDEN DONALD B
权利人:UNIV GEORGIA STATE
摘要:A method of preparation of substituted halogenodiazines which are useful as intermediates in the synthesis of novel unfused heterobicyclic compounds, and the products thereof. The reaction consists of the addition of an organolithium reagent with subsequent dehydrogenation of the addition product. The reaction takes place in one reaction vessel, without isolation of the substituted halogenodihydrodiazine intermediate. The reactions proceed at moderate temperature and in a short amount of time, which decreases the probability of side reactions and increases yield. Furthermore, the workup step is conducted under two-phase conditions to prevent hydrolysis of the substituted halogenodiazine to a substituted hydroxydiazine. The method is easy, efficient and results in a high yield of product. The substituted halogenodiazines are used as intermediates in the synthesis of unfused heterobicyclic compounds containing an aromatic moiety, diazine, and another aromatic moiety, such as thiophene, benzene, or naphthalene, which have biological activity.

专利号:US-2024400558-A1
优先权日:2021-09-09
标题 :Processes and intermediates for synthesis of adagrasib
发明人：SCATTOLIN THOMAS; CHEN CHENG; GHARBAOUI TAWFIK; GAN YONGHONG; ACHMATOWICZ MICHAL; SNEAD DAVID
权利人:MIRATI THERAPEUTICS INC
摘要:The present invention relates to improved synthetic routes of synthesizing adagrasib. The invention also provides intermediates used in the provided synthetic routes.

专利号:US-5214130-A
优先权日:1990-02-27
标题 :Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
发明人：PATCHETT ARTHUR A; TAUB DAVID; GOEGELMAN ROBERT T
权利人:MERCK & CO INC
摘要:New immunosuppressive cyclosporin analogs are disclosed consisting of [dehydro-Ala]8 cyclosporins and derived therefrom cyclosporins having a sulfur containing amino acid at position-8.

专利号:US-4963676-A
优先权日:1988-02-09
标题 :Di-substituted phthalazines
发明人：STREKOWSKI LUCJAN; MOKROSZ MARIA; HARDEN DONALD B
权利人:UNIV GEORGIA STATE
摘要:A method of preparation of substituted halogenodiazines which are useful as intermediates in the synthesis of novel unfused heterobicyclic compounds, and the products thereof. The reaction consists of the addition of an organolithium reagent with subsequent dehydrogenation of the addition product. The reaction takes place in one reaction vessel, without isolation of the substituted halogenodihydrodiazine intermediate. The reactions proceed at moderate temperature and in a short amount of time, which decreases the probability of side reactions and increases yield. Furthermore, the workup step is conducted under two-phase conditions to prevent hydrolysis of the substituted halogenodiazine to a substituted hydroxydiazine. The method is easy, efficient and results in a high yield of product. The substituted halogenodiazines are used as intermediates in the synthesis of novel unfused heterobicyclic compounds containing an aromatic moiety, diazine, and another aromatic moiety, such as thiophene, benzene, or naphthalene, which have biological activity.

专利号:US-2018208555-A1
优先权日:2013-11-18
标题 :Method of synthesis of an ionizable cationic lipid

专利号:US-2023250056-A1
优先权日:2020-06-24
标 题 :Process for synthesizing lipids
发明人：BEUTNER GREGORY LOUIS; LORA GONZALEZ FEDERICO; CHO PATRICIA Y; SMITH MICHAEL J
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present application provides processes for synthesizing lipids of Formula I useful in the synthesis of fat-soluble compounds for targeting and enhancing activity of therapeutic molecules, including siRNA.