CAS: 112212-94-9; Tetrahydrothiophene-2-Carbonitrile

相似化合物

19418-11-2 13679-85-1 4781-83-3

上下游产品

(3-Chloropropylthio)acetonitrile thiophene P-toluenesulfonyl cyanide (+)-Tetrahydrothiophene-2-carboxylic acid tetrahydrothiophene-2-carbonyl chloride Tetrahydrothiophene-2-carboxanilide

📜(3-Chloropropylthio)Acetonitrile置于苄基三乙基氯化铵 Sodium Hydroxide体系中,用 水 用作溶剂,化学反应 1.0H,以80%的收率获得2-氰基四氢噻吩
参考文献:Spiro Derivatives Of Tetrahydrothiophene. Synthesis Of The Quinolizidine <3-Spiro-2'> Tetrahydrothiophene System Using Solid/liquid Or Liquid/liquid Phase-Transfer Catalysis
标题:Spiro Derivatives Of Tetrahydrothiophene. Synthesis Of The Quinolizidine <3-Spiro-2'> Tetrahydrothiophene System Using Solid/liquid Or Liquid/liquid Phase-Transfer Catalysis
摘要:4-氧代八氢喹啉<3-螺-2'>四氢噻吩1',1'-二氧化物可以通过两条独立的途径从2-氰基四氢噻吩合成,两者均使用相转移催化:第一条途径涉及在ptc条件下对2-氰基四氢噻吩进行烷基化,第二条途径则是使用2-氯乙基哌啶与2-氯羰基四氢噻吩进行n-酰化,最后在ptc条件下进行环烷基化.得到两个螺旋化合物的立体异构体.
Doi:10.1055/s-1987-33430

专利信息

专利号:US-5856501-A
优先权日:1997-03-11
标题 :Synthesis of thiazole derivatives
发明人：MALCOLM ARCELIO J; WU TSE-CHONG
权利人:ALBEMARLE CORP
摘要:N- 4-(cyanoethylthiomethyl)-2-thiazolyl!guanidine--a key intermediate for preparing the pharmaceutical, famotidine--is produced by mixing in a liquid medium formed from a chemically indifferent organic solvent and water, and under an inert atmosphere, (i) a 2-guanidino-4-halomethylthiazole or a hydrohalide complex thereof, (ii) an S-(2-cyanoethyl)isothiourea or a hydrohalide complex thereof, and (iii) a strong alkali metal base. In lieu of (ii), an alkali metal salt of 2-cyanoethyl-1-thiol can be used, and in such case use of (iii) is optional, but preferable.

专利号:WO-9840368-A1
优先权日:1997-03-11
标题 :Synthesis of thiazole derivatives

专利号:US-5731442-A
优先权日:1997-03-11
标 题 :Synthesis of thiazole derivatives