CAS: 100898-63-3; N-(1-((2R,4S,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxytetrahydrofuran-2-yl)-2-Oxo-1,2-Dihydropyrimidin-4-yl)Acetamide

相似化合物

121058-82-0 199593-08-3 159414-98-9

上下游产品

4,4'-dimethoxytrityl chloride 4-acetyl-2'-deoxycytidineN4-acetyl-2'-deoxycytidine 2'-Deoxycytidine 4,4'-dimethoxytrityl alcohol 5'-O-(4,4'-dimethoxytrityl)deoxycytidine Acetic acid (2R,3S,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

📜二(4-甲氧基苯基)(苯基)甲醇置于n,N-二异丙基乙胺体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 4.0H,反应生成N-乙酰基-5'-O-(4,4'-二甲氧基三苯甲基)-2'-脱氧胞苷
参考文献:在温和条件下不使用银盐对醇进行三酰化
标题:在温和条件下不使用银盐对醇进行三酰化
摘要:在温和条件下,在短运行时间内,将三醇方便地与由三苯甲醇和三氟乙酸酐原位生成的三氟乙酸三苯乙铵进行三苯甲基化.反应不需要昂贵的银盐.四种仲醇与单和二甲氧基三苯甲基醇一起三苯甲基化,具有非常好的优异分离产率.还对具有伯醇的四种核苷衍生物测试了该反应.还获得令人满意的结果.
Doi:10.1016/j.Tetlet.2016.07.062

专利信息

专利号:US-12428442-B2
优先权日:2017-06-21
标题 :Compounds, compositions and methods for synthesis
发明人：BUTLER DAVID CHARLES DONNELL; HENCKEN CHRISTOPHER P; IWAMOTO NAOKI; KANDASAMY PACHAMUTHU; LANAO ALVARO ANDRES; LU GENLIANG; SHIMIZU MAMORU; DIVAKARAMENON SETHUMADHAVAN; VARGEESE CHANDRA; BOMMINENI GOPAL REDDY; MARAPPAN SUBRAMANIAN
权利人:WAVE LIFE SCIENCES LTD
摘要:The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

专利号:US-5616700-A
优先权日:1992-04-24
标 题:Processes for synthesizing nucleotides and modified nucleotides using N.sub.
发明人：REDDY M PARAMESWARA; FAROOQUI FIRDOUS
权利人:BECKMAN INSTRUMENTS INC
摘要:Disclosed herein are protecting groups for exocyclic amino groups of the base cytosine for use in the synthesis of oligonucleotides and oligonucleoside phosphorothioates, the protecting groups being represented by the formula: -CO-(CH2)0-9-CH3. In a particularly preferred embodiment, the base cytosine is protected with acetyl (-CO-CH3), and the oligonucleotide or oligonucleoside phosphorothioate incorporating the protected cytosine is subjected to a cleavage/deprotection reagent comprising methylamine and ammonia.