CAS: 91872-10-5; 3,5-Dibromo-6-Methyl-2-Pyridinamine

• 英文名称3,5-Dibromo-6-Methyl-2-Pyridinamine
• 中文名称2-氨基-3.5-二溴-6-甲基吡啶
• IUPAC名称3,5-dibromo-6-methylpyridin-2-amine
• 其它别名2-氨基-3,5-二溴-6-甲基吡啶(Cas号:91872-10-5); 6-Amino-3,5-Dibromo-2-Picoline
• CAS编号91872-10-5
• MFCD编号:MFCD00068229
• EINECS号:623-093-5
• 分子式:C6H6Br2N2
• 分子量:265.94
• 产品CID: 1956932
• 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

• 相似结构搜索
• InChIKey: BLUYMDMBXIMIGK-UHFFFAOYSA-N
• InChI=1S/C6H6Br2N2/c1-3-4(7)2-5(8)6(9)10-3/h2H,1H3,(H2,9,10)…
• 计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

相似化合物

物理性质

• 熔点143.5-148.5°C
• 沸点93 °C at 760 mmHg
• 闪点112.0±25.9 °C
• 密度2.0±0.1 g/cm3
• pKa:2.04±0.50(预测)
• PSA:38.91
• LogP:2.49722
• 折射率1.651
• 蒸汽压0.0±0.5 mmHg at 25°C
• 溶解性Slightly Sol. In Methanol
• 敏感性按规定使用和贮存的不会分解，避氧化物
• 外观形态白色至浅红色至绿色粉末至晶体
• 储存条件请置于阴暗处, 惰性气氛中,室温
• 产品应用该化合物用于合成1-[(3-5-二溴二苯醚-6-甲甲基-2-丙烯基)-甲苯基]-2-甲丙烯醇和3-5二溴-六-甲基-2--丙烯酮.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
• 危险等级IRRITANT
• UN编号NONH for all modes of transport
• 危险品标志Xi,Xn
• 安全声明26-36
• 危险类别码36/37/38-20/21/22
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 2-Amino-3,5-Dibromo-6-Methylpyridine 主要起始原料 2-Amino-6-Methylpyridine
• 1824-81-3 = 91872-10-5
  反应条件:1.1 Reagents: Nadph,Glutathione,Fad,Sodium Bromide,Dl-Glucose Catalysts: Catalase,Glucose Dehydrogenase,Haloperoxidase; 12 - 16 H,Rt
  标题:The Single-Component Flavin Reductase/flavin-Dependent Halogenase Aetf Is A Versatile Catalyst For Selective Bromination And Iodination Of Arenes And Olefins
  作者:Jiang,Yuhua; Snodgrass,Harrison M.; Zubi,Yasmine S.; Roof,Caitlin V.; Guan,Yanfei; Et Al
  参考文献:Angewandte Chemie 日期:2022 卷标:61(51)]
  
  1824-81-3 = 91872-10-5
  反应条件:1.1 Reagents: Nad,Glutathione,Fad,Sodium Bromide,Dl-Glucose Catalysts: Catalase,Glucose Dehydrogenase,Haloperoxidase
  标题:The Single Component Flavin Reductase/flavin Dependent Halogenase Aetf Is A Versatile Catalyst For Selective Bromination And Iodination Of Arenes And Olefins
  作者:Jiang,Yuhua; Snodgrass,Harrison M.; Zubi,Yasmine S.; Roof,Caitlin V.; Guan,Yanfei; Et Al
  参考文献:Chemrxiv 日期:2022 卷标:1 页码:1-10]
  
  1824-81-3 = 91872-10-5
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dimethylformamide; 30 Min,Rt; 30 Min,Rt1.2 Reagents: Sodium Carbonate Solvents: Water; Ph 7,< Rt
  标题:Discovery Of Heterobicyclic Templates For Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists
  作者:Kulkarni,Santosh S.; Newman,Amy Hauck
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2007 卷标:17(11) 页码:2987-2991]
  
  = 91872-10-5 [标题:Reaction Conditions
  标题:Identification Of 2-Amino-5-Aryl-Pyrazines As Inhibitors Of Human Lactate Dehydrogenase
  作者:Fauber,Benjamin P.; Dragovich,Peter S.; Chen,Jinhua; Corson,Laura B.; Ding,Charles Z.; Et Al
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2013 卷标:23(20) 页码:5533-5539]
  
  125040-56-4 = 91872-10-5
  反应条件:1.1 Reagents: Hydrogen Peroxide Solvents: Water; 3 D,Rt; 3 W,Rt
  标题:Oxidative Bromination Of Imidazoheterocycle Bromohydrates
  作者:Kovalenko,N. V.; Cherepakha,A. Yu.; Kutrov,G. P.; Shishkin,O. V.; Shishkina,S. V.
  参考文献:Chemistry Of Heterocyclic Compounds (New York 日期:2012 卷标:47(10) 页码:1280-1285]
  
  5327-33-3 = 91872-10-5
  反应条件:1.1 Reagents: N-Bromosuccinimide,Perchloric Acid Solvents: Carbon Tetrachloride1.2 Reagents: Sodium Bicarbonate
  标题:N-Bromosuccinimide Reactions Of Some Heterocycles In The Presence Or Absence Of Water: An Overview Of Ring Versus Side Chain Bromination For The Synthesis Of Important Brominated Heterocyclic Synthons
  作者:Goswami,Shyamaprosad; Ghosh,Kumaresh; Mukherjee,Reshmi; Adak,Avijit Kumar; Mahapatra,Ajit Kumar
  参考文献:Journal Of Heterocyclic Chemistry 日期:2001 卷标:38(1) 页码:173-178]
  
  42753-71-9 = 91872-10-5
  反应条件:1.1 Reagents: Sodium Bromide,Sulfuric Acid,Sodium Bromate Solvents: Acetonitrile,Water; 30 Min,5 - 10 °C; 8 H,5 - 10 °C
  标题:Environment-Friendly Bromination Of Aromatic Heterocycles Using A Bromide-Bromate Couple In An Aqueous Medium
  作者:Joshi,Girdhar; Adimurthy,Subbarayappa
  参考文献:Industrial & Engineering Chemistry Research 日期:2011 卷标:50(21) 页码:12271-12275]
  
  1824-81-3 = 91872-10-5
  反应条件:1.1 Reagents: Hydrogen Peroxide,Bromine Catalysts: Sulfuric Acid Solvents: Tetrahydrofuran,Water; 8 H,65 °C
  标题:Preparation Of 2-Amino-3-Bromo-6-Methylpyridine
  参考文献:China]
  
  = 91872-10-5 [标题:Reaction Conditions
  标题:Halogenation Of N-Oxides Of Pyridine Acetylamino Derivatives
  作者:Talik,Tadeusz; Talik,Zofia
  参考文献:Prace Naukowe Akademii Ekonomicznej Imienia Oskara Langego We Wroclawiu 日期:1983 卷标:238 页码:97-106]
  
  = 91872-10-5 [标题:Reaction Conditions
  标题:Synthesis Of The Mutagenic 2-Amino-1,6-Dimethylimidazo[4,5-B]Pyridine (1,6-Dmip) And Five Of Its Isomers
  作者:Lindstroem,Stefan; Ahmad,Tania; Grivas,Spiros
  参考文献:Heterocycles 日期:1994 卷标:38(3) 页码:529-40]
  
  1824-81-3 = 91872-10-5 + 42753-71-9
  反应条件:1.1 Reagents: Sodium Acetate Solvents: Acetic Acid; 20 - 22 °C; 22 °C -> 15 °C1.2 Reagents: Bromine Solvents: Acetic Acid; 10 - 15 °C; 1 H,15 °C
  标题:Improvement Of The Synthesis Of 6-Bromo-5-Methylimidazo[4,5-B]Pyridine,A Stabilizer For Color Photography
  作者:Yutilov,Yu. M.; Svertilova,I. A.; Minkina,L. V.; Kirillova,K. M.; Smolyar,N. N.
  参考文献:Russian Journal Of Applied Chemistry 日期:2005 卷标:78(5) 页码:787-790]
  
  1824-81-3 = 91872-10-5 + 42753-71-9 + 126325-46-0
  反应条件:1.1 Reagents: Hydrogen Peroxide,Hydrogen Bromide Solvents: Water
  标题:Bromination Of Pyridines. Ii. Bromination Of Aminopicolines
  作者:Dunn,A. D.; Currie,A.; Hayes,L. E.
  参考文献:Journal Fuer Praktische Chemie (Leipzig) 日期:1989 卷标:331(3) 页码:369-74

海关参考信息

• 2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

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• ➥ 防范代码详解
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