CAS: 6665-67-4; 5-Hydroxy-2-(4-Hydroxyphenyl)-4H-Chromen-4-One

上下游产品

CAS号699-83-2 2,6-二羟基苯乙酮 | CAS号41046-67-7 2-碘间苯二酚 | CAS号141993-06-8 4-(5-tributylst... | CAS号133642-20-3 4-(tert-butyldi... | CAS号99-76-3 尼泊金甲酯 | CAS号491-78-1 5-羟基黄酮 | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号745-39-1 5,4'-diacetoxyf... | CAS号6665-72-1 5-Hydroxy-2-(4-...

📜5-羟基黄酮置于aspergillus Alliaceous (Atcc 10060)体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 336.0H,以0.46%的收率获得产物5,4 '-二羟基黄酮
参考文献:Microbial Metabolism Part 9. Structure And Antioxidant Significance Of The Metabolites Of 5,7-Dihydroxyflavone (Chrysin),And 5-And 6-Hydroxyflavones
标题:Microbial Metabolism Part 9. Structure And Antioxidant Significance Of The Metabolites Of 5,7-Dihydroxyflavone (Chrysin),And 5-And 6-Hydroxyflavones
摘要:5,7-二羟基黄酮(克里西因)(1)在与真菌培养物(葱状曲霉atcc 10060,白僵病真菌atcc 13144和灰色霉菌atcc 22752)发酵时,主要产生4'-羟基克里西因(4),克里西因7-O-β-D-4-O-甲基葡萄糖苷(5)和克里西因7-硫酸酯(6).然而,穆科雷.拉曼尼安斯(atcc 9628)则将克里西因转化为六种代谢物:4'-羟基-3'-甲氧基克里西因(克里索埃里奥尔)(7),4'-羟基克里西因(阿比金)(4),3',4'-二羟基克里西因(芦丁)(8),3'-甲氧基克里西因4'-O-α-D-6-去氧阿洛糖苷(9),克里西因4'-O-α-D-6-去氧阿洛糖苷(10)以及芦丁3'-硫酸酯(11).葱状曲霉(atcc 10060)和白僵病真菌(atcc 13144)的培养物将5-羟基黄酮(2)代谢为5,4'-二羟基黄酮(12)和4'-羟基黄酮5-O-β-D-4-O-甲基葡萄糖苷(13).6-羟基黄酮(3)在白僵病真菌(atcc 13144)培养物中转化为6-羟基黄酮酮(14),黄酮3-O-β-D-4-O-甲基葡萄糖苷(15)以及(+/-)-黄酮6-O-β-D-4-O-甲基葡萄糖苷(16).代谢产物的结构通过光谱数据得到阐明.简要讨论了这些代谢物作为抗氧化剂的结构意义.
DOI:10.1248/cpb.56.418

专利信息

专利号:CN-111039910-A
优先权日:2019-12-31
标题 :A kind of method and application of photo-initiated synthesis of 3-aryl flavonoids or coumarin compounds

专利号:US-7842721-B2
优先权日:2007-08-24
标题:Composition for treating cancer cells and synthetic method for the same
发明人：LIN AN-SHEN; WU YANG-CHANG; LEE KUO-HSIUNG; CHANG FANG-RONG
权利人:UNIV KAOHSIUNG MEDICAL
摘要:A pharmaceutical composition having a cytotoxic effect to a cancer cell is provided. The pharmaceutical composition includes a flavonoid compound having a formula as n nwherein B ring is a 4-oxo-cyclohexa-2,5-dienyl group, and any one of R 1 -R 12 is one selected from a group consisting of hydrogen group, hydroxyl group, C1-C20 alkyl group, C1-C20 ether group, C1-C20 ester group, carboxyl group, halogen and sugar. The flavonoid compound is obtained from a chemical method being one of a total synthesis method and a semi-synthesis method.