CAS: 63074-08-8; (4-(4-Amino-6,7-Dimethoxyquinazolin-2-yl)Piperazin-1-yl)(Tetrahydrofuran-2-yl)Methanone Hydrochloride

特拉唑嗪 在 盐酸体系中,反应 2.87H,获得 Terazosin hydroChloride
参考文献:Preparation Of Acid Addition Salts Of Amine Bases By Solid Phase-Gas Phase Reactions
标题:Preparation Of Acid Addition Salts Of Amine Bases By Solid Phase-Gas Phase Reactions
摘要:将有机碱以固体形式暴露于气态酸中,制备有机碱的酸加盐的方法,但须排除齐拉西酮,其酸加盐和中间体.

专利信息

专利号:US-6080860-A
优先权日:1992-08-31
标 题:Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
发明人：KARIMIAN KHASHAYAR; MURTHY KESHAVA; HALL DARREN
权利人:BRANTFORD CHEMICALSS INC
摘要:Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediates suitable for use in such methods of synthesis are taught.

专利号:US-6130218-A
优先权日:1996-12-20
标 题 :Polymorphic form of doxazosin mesylate (Form I)
发明人：MOERSDORF JOHANN PETER; GRAFE INGOMAR
权利人:HEUMANN PHARMA GMBH & CO
摘要:A new crystalline and anhydrous form of doxazosin mesylate is described. The new form is crystalline and anhydrous and is characterized in its X-ray spectrum by the following reflex positions of high and medium intensity: 15.40°, 16.85°, 18.06°, 24.15° and 25.81°. Owing to its crystalline properties, the new form of doxazosin mesylate according to the invention has surprising advantages both with regard to its synthesis and for pharmaceutical processing into solid dosage forms. A process for preparing the new form of doxazosin mesylate and pharmaceutical compositions comprising the new form of doxazosin mesylate are also described.

专利号:US-6133269-A
优先权日:1996-12-20
标题:Polymorphic form of doxazosin mesylate (form II)
发明人：MOERSDORF JOHANN PETER; GRAFE INGOMAR
权利人:HEUMANN PHARMA GMBH & CO
摘要:A new crystalline and anhydrous form of doxazosin mesylate is described. The new form is crystalline and anhydrous and is characterized in its X-ray spectrum by the following reflex positions of high and medium intensity: 10.68°, 14.45°, 17.37°, 23.45°, 23.82° and 24.30 °. Owing to its crystalline properties, the new form of doxazosin mesylate according to the invention has surprising advantages both with regard to its synthesis and for pharmaceutical processing into solid dosage forms. A process for preparing the new form of doxazosin mesylate and pharmaceutical compositions comprising the new form of doxazosin mesylate are also described.

专利号:US-6140334-A
优先权日:1996-12-20
标题 :Polymorphic form of doxazosin mesylate (form III)
发明人：MOERSDORF JOHANN PETER; GRAFE INGOMAR
权利人:HEUMANN PHARMA GMBH & CO
摘要:A new crystalline and anhydrous form of doxazosin mesylate is described. The new form is crystalline and anhydrous and is characterized in its X-ray spectrum by the following reflex positions of high and medium intensity: 8.49°, 11.72°, 16.03°, 18.29°, 21.03°, 22.87° and 25.02°. Owing to its crystalline properties, the new form of doxazosin mesylate according to the invention has surprising advantages both with regard to its synthesis and for pharmaceutical processing into solid dosage forms. A process for preparing the new form of doxazosin mesylate and pharmaceutical compositions comprising the new form of doxazosin mesylate are also described.

专利号:WO-9405628-A1
优先权日:1992-08-31
标 题 :Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor

专利号:EP-0656885-A1
优先权日:1992-08-31
标 题 :Synthesis of 2-substituted quinazoline compounds (such as terazosin) and meobentine and bethanidine and intermediates therefor