CAS: 59-06-3; Methyl 4-Acetamido-2-Ethoxybenzoate

上下游产品

methyl 4-acetamido-2-hydroxybenzoate ethyl iodide ethyl bromide 4-Aminosalicylic acid2-ethoxy-4-aminobenzoic acid methyl 4-(acetylamino)-2-ethoxy-5-nitrobenzoate methyl 4-acetylamino-5-bromo-2-ethoxybenzoate methyl 4-acetylamino-2-ethoxy-5-iodobenzoate

4-氨基水杨酸置于硫酸,溶剂黄146,Sodium Hydroxide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 3.0H,反应生成 乙氧酰胺苯甲酯
参考文献:Synthesis And Biological Evaluation Of Berberine Derivatives As Ibs Modulator
标题:Synthesis And Biological Evaluation Of Berberine Derivatives As Ibs Modulator
摘要:肠易激综合征是最常见的功能性胃肠道疾病,其特点是慢性腹痛或不适,并伴有排便习惯的改变.5-Ht 受体调节剂已被开发为肠易激综合征的治疗药物,并被证明能有效治疗该疾病.在这封信中,我们设计并合成了 12 种小檗碱衍生物作为 5-Ht 受体调节剂.初步生物测试表明,这些新化合物在治疗肠易激综合征方面具有非常好的活性.
DOI:10.2174/157018012800389386

专利信息

专利号:US-8188282-B2
优先权日:2006-07-15
标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

专利号:AU-2007276514-A1
优先权日:2006-07-15
标题:A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CA-2657717-A1
优先权日:2006-07-15
标 题 :A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CN-101490014-B
优先权日:2006-07-15
标 题:Regioselective palladium-catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CN-101490014-A
优先权日:2006-07-15
标题:Regioselective palladium-catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:EP-2044033-B1
优先权日:2006-07-15
标题:A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles