CAS: 5707-55-1; 2-(3,4-Dihydroxyphenyl)Acetaldehyde

上下游产品

Norepinephrine Epinephrine 3)-4-O-caffeoyl-β-D-glucopyranosideβ-3,4-trihydroxyphenethyl-O-α-L-rhamnopyranosyl-(1*3)-4-O-caffeoyl-β-D-glucopyranoside benzo[1,3]dioxol-5-yl-acetaldehyde (3,4-dihydroxy-phenyl)-acetaldehyde-semicarbazone (3,4-dihydroxy-phenyl)-acetaldehyde-(2,4-dinitro-phenylhydrazone) Norlaudanosolin 6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,9,10-tetraol

📜羟基酪醇置于三氧化硫吡啶,N,N-二异丙基乙胺体系中,用 二氯甲烷,二甲基亚砜 作为反应溶剂,化学反应 0.5H,以43%的收率获得产物2-(3,4-二羟基苯基)乙醛
参考文献:揭示了黄连ncs2的催化潜力-基于氟胺的测定方法的开发和利用
标题:揭示了黄连ncs2的催化潜力-基于氟胺的测定方法的开发和利用
摘要:研究了来自黄连ncs2的正月桂氨酸合成酶(ncs)的多功能性和潜力,以及使用近四十种胺/醛的新型荧光高通量测定方法的开发和应用.已经确定了cj Ncs2对选定的非天然底物施加的立体控制,其中天然氢去甲可可碱在> 95%ee中形成了四氢异喹啉(thias)作为(1 S)异构体.利用报告的黄藻ncs X射线晶体结构对涉及thia机制中间体的对接计算,并与cj结合ncs2筛选结果可进一步了解ncs的作用方式.这些发现表明,除了关键的活性位点残基k122和e110,D141对于酶促转化在机械上也是必不可少的.我们提出的机理进一步支持了ncs对醛底物的超强耐受性,其中醛从酶口袋中伸出.
DOI:10.1002/adsc.201200641

专利信息

专利号:US-10662453-B2
优先权日:2014-06-19
标 题:Compositions and methods for making (S)-norcoclaurine and (S)-norlaudanosoline, and synthesis intermediates thereof
发明人：FACCHINI PETER JAMES
权利人:WILLOW BIOSCIENCES INC
摘要:Methods that may be used for the manufacture of the chemical compound (S)-norcoclaurine, (S)-norlaudanosoline, and (S)-norcoclaurine or (S)-norlaudanosoline synthesis intermediates are provided. (S)-Norcoclaurine, (S)-norlaudanosoline, and (S)-norcoclaurine or (S)-norlaudanosoline synthesis intermediates are useful as precursor products in the manufacture of certain medicinal agents.

专利号:CN-117305200-A
优先权日:2023-07-03
标题 :A recombinant bacterium and its application in the synthesis of 3,4-dihydroxyphenylethylamine

专利号:US-11371065-B2
优先权日:2017-08-04
标题 :Genetically engineered strain
发明人：CAI YUJIE; LIU JINBIN; XIONG TIANZHEN; DING YANRUI; BAI YAJUN; ZHENG XIAOHUI
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses a genetically engineered strain, belonging to the technical field of bioengineering. L-amino acid oxidase genes, α-keto acid decarboxylase genes, alcohol dehydrogenase genes, and enzyme genes capable of reducing NAD(P) to NAD(P)H are introduced into the genetically engineered strain of the present disclosure. The present disclosure further discloses a construction method and application of a recombinant Escherichia coli genetically engineered strain. When being applied to the biosynthesis of phenylethanoids, the method of the present disclosure has the characteristics of simple operation, low cost, and high synthesis efficiency and optical purity of the product, and has good industrialization prospects.