CAS: 56725-99-6; 3,5-Dihydroxy-2-(4-Methoxyphenyl)-8-(3-Methylbut-2-En-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One

该化合物是主要来自植物的天然化合物,该物质主要来自植物精液Epimed, 俗称"角性山羊weed",该物质属于一种类菜菜类,具体地说是一种甘蔗,其特点是附着于骨的糖味.Icariside I的潜在药理特性,包括抗氧化剂,抗炎和...

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物理性质

MSDS等安全信息

上下游产品

淫羊藿苷 Icariin 489-32-7
去水淫羊藿黄素 Icaritin 118525-40-9
四乙酸堪非醇酯 3,5,7-Triacetoxy-2-(4-Acetoxy-Phenyl)-Chromen-4-One 16274-11-6
山奈酚 Kaempferol 520-18-3

合成工艺路线路线简述

    📜山奈酚置于吡啶,盐酸,Tris(6,6,7,7,8,8-Heptafluoro-2,2-Dimethyl-3,5-octadionato)Europium(Iii),18-冠醚-6,1,4-环己二烯,Palladium 10% On Activated Carbon,氨,Potassium Carbonate,N,N-二异丙基乙胺,硫酸二甲酯,Silver Carbonate,Potassium Iodide体系中,用 甲醇,二氯甲烷,氯仿,水,N,N-二甲基甲酰胺,氯苯,丙酮 作为反应溶剂,化学反应 86.83H,反应生成 淫羊藿次苷i
    参考文献:通过区域选择性甲基化和对-Claisen-Cope重排从山ka酚中合成二十碳五烯.
    标题:通过区域选择性甲基化和对-Claisen-Cope重排从山ka酚中合成二十碳五烯.
    摘要:天然存在的生物活性类黄酮糖苷icariin(1)的半合成已通过11个步骤完成,山emp酚的总收率为7%.山emp酚的4'-Oh甲基化,3-O-甲氧基甲基-4'-O-甲基-5-O-异戊烯基-7-O-苄基山ka酚的8-烯丙基化(8) Nahco3存在下的eu(fod)3和icaritin(3)的糖基化是关键步骤.
    DOI:10.3762/bjoc.11.135

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    专利信息


    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

    专利号:CN-101205223-B
    优先权日:2006-12-18
    标题:A kind of total synthesis method of natural product icariin compound

    专利号:CN-101205223-A
    优先权日:2006-12-18
    标 题 :A kind of total synthesis method of natural product icariin compound

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    主要参考文献


    1: Wang M, Gao H, Li W, Wu B. Icariin and its metabolites regulate lipid metabolism: From effects to molecular mechanisms. Biomed Pharmacother. 2020 Nov;131:110675. doi: 10.1016/j.biopha.2020.110675. Epub 2020 Aug 28.
    177:112836. doi: 10.1016/j.jpba.2019.112836. Epub 2019 Aug 26. 85(4):347-355. doi: 10.1055/a-0806-7673. Epub 2018 Dec 6. 13(49):90-94. doi: 10.4103/0973-1296.197654.
    5: Cheng T, Sheng T, Yi Y, Zhang T, Han H. Metabolism profiles of icariin in rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and in vitro enzymatic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:353-360. doi: 10.1016/j.jchromb.2016.09.010. 21(9):1158. doi: 10.3390/molecules21091158.

    合成参考文献


    参考文献:10.1016/0031-9422(96)00187-2
    摘要:Li WK, Zhang RY, Xiao PG. Flavonoids from Epimedium wanshanense. Phytochemistry. 1996 Sep;43(2):527–30. doi: 10.1016/0031-9422(96)00187-2.
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