专利号:US-6730790-B2 优先权日:2002-03-01 标 题:Chlorinated heterocyclic compounds and methods of synthesis 发明人:KWIATKOWSKI STEFAN; GOLINSKI MIROSLAW 权利人:R T ALAMO VENTURES I LLC 摘要:Compositions of the present invention comprise chlorinated heterocyclic compounds, including racemic monochloroflosequinan, purified enantiomers of monochloroflosequinan and the sulfone derivative of monochloroflosequinan. The methods of the present invention comprise the synthesis of racemic monochloroflosequinan and derivatives thereof, including the sulfone derivative. Intermediates in the synthesis are also provided. The methods further comprise the synthesis of enantiomers of monochloroflosequinan.
专利号:US-7230119-B2 优先权日:2004-08-25 标 题 :Process for the preparation of substituted pyrrolidine derivatives and intermediates 发明人:CHAND POORAN; EL-KATTAN YAHYA; KOTIAN PRAVIN L 权利人:BIOCRYST PHARM INC 摘要:Two syntheses are provided; one for the preparation of (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol, and other for the preparation of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol. (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is prepared using the achiral ylide prepared from benzylamine instead of phenethylamine (Scheme 3) which provides a crystalline intermediate. The synthesis of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is achieved from (S)-diethylmalate as described in Scheme 4. A process for preparing camphor sultam is also provided.
专利号:WO-2004074215-A1 优先权日:2003-02-03 标 题 :Process for preparation of clopidogrel, its salts and pharmaceutical compositions 发明人:NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI 权利人:NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI 摘要:The invention discloses an improved process for racemization of methyl (R)Â(-) alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate , a stereoisomer formed in the synthesis of clopidogrel i.e. methyl (S)-(+)-alpha (2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate or its salts. The invention is also for an improved process for production of clopidogrel or its pharmaceutically acceptable salts. The invention further discloses novel clopidogrel salts and pharmaceutical compositions comprising them.
专利号:US-2011002837-A1 优先权日:2009-12-17 标 题:Enhancement of quality and quantity of carbon nanotubes during growth by addition of miscible oxygenates 发明人:MAGHREBI MORTEZA; KHODADADI ABBASALI; MORTAZAVI YADOLLAH; SANE ALI 权利人:MAGHREBI MORTEZA; KHODADADI ABBASALI; MORTAZAVI YADOLLAH; SANE ALI 摘要:Disclosed is an experimental setup for synthesis of carbon nanotubes by floating catalyst method which comprises of a feeding and a reactor system. FIG. 1, illustrates CNT growth apparatus set up 100. The feeding system includes a syringe pump 115 for injecting of feed solution, liquid spraying, and or solid sublimation. The reactor system has a centrally located tubular quartz furnace 105, having a diameter of about 21.7 mm and divided into two zones.
专利号:US-10087136-B2 优先权日:2016-01-26 标 题 :Process for the preparation of Metaraminol 发明人:BRENNA DAVIDE; MARCHESI ANDREA; MIHALI Voichita 权利人:LABORATORI ALCHEMIA S R L 摘要:Object of the invention is a process for the preparation of Metaraminol and the salts thereof, in particular its pharmaceutically acceptable salts, especially Metaraminol bi-L-tartrate. Object of the invention is also the use of a novel catalyst and a novel ligand for the synthesis of Metaraminol and its salts.
专利号:US-2021238374-A1 优先权日:2020-02-04 标 题 :Templated synthesis of nanovoided polymers 发明人:YE SHENG; LANDIG RENATE EVA KLEMENTINE; DIEST KENNETH ALEXANDER; OUDERKIRK ANDREW JOHN; BOWMAN CHARLES ROBERT; BOWMAN ROBERT G; HENDRICKSON WILLIAM ARTHUR; RUEB CHRISTOPHER J; PURVIS II LAFE JOSEPH; SUN WENMO; LI RYAN; YAROSHCHUK OLEG; RAO TINGLING; BOROMAND ARMAN; ZHAO CHURNING; Khaleghimeybodi Morteza 权利人:FACEBOOK TECH LLC 摘要:A method of forming a voided polymer includes forming a polymerizable composition containing a polymer precursor and a solid templating agent, forming a coating of the polymerizable composition, processing the coating to form a cured polymer material having a solid phase in a plurality of defined regions, and removing at least a portion of the solid phase from the cured polymer material to form a voided polymer layer.
1: Cordoba Torres IT, Marino-Nieto J, Barkin HB, Fort AC, Cobas M. Vicks® VapoRub™ intoxication: An unusual presentation of multiorgan failure. J Clin Anesth. 2018 May 7;48:46-47. doi: 10.1016/j.jclinane.2018.04.017. [Epub ahead of print] doi: 10.1016/j.micpath.2018.04.033. [Epub ahead of print] doi: 10.1364/OE.25.002983. doi: 10.1098/rsos.171424. eCollection 2018 Feb. 8: Cabrera-Peralta J, Peña-Alvarez A. Simple method for the determination of personal care product ingredients in lettuce by ultrasound-assisted extraction combined with solid-phase microextraction followed by GC-MS. J Sep Sci. 2018 Feb 19. doi: 10.1002/jssc.201701244. [Epub ahead of print] doi: 10.1039/c7an01855j. doi: 10.1016/j.phytochem.2018.01.014. Epub 2018 Feb 6. eCollection 2017. 12: Coffinet M, Behr JB, Jaroschik F, Harakat D, Vasse JL. Single or Synergistic Kinetic Resolutions of Chiral Allylalanes: Two Complementary Routes for the Asymmetric Synthesis of Syn Homoallylamines. Org Lett. 2017 Dec 15;19(24):6728-6731. doi: 10.1021/acs.orglett.7b03455. Epub 2017 Dec 6. doi: 10.1016/j.aca.2017.09.047. Epub 2017 Oct 15. doi: 10.1016/j.micpath.2017.11.004. Epub 2017 Nov 7. doi: 10.1142/S0192415X1750094X. Epub 2017 Nov 9. pii: E2280. doi: 10.3390/ijms18112280.
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