CAS: 464-49-3; (1R,4R)-1,7,7-Trimethylbicyclo[2.2.1]Heptan-2-One

该化合物是一个双环单体单体酮,产自露营树木(Cinamommum camphora)的木材,是无色或白色晶状固体,具有特殊的芳香味,以独特的冷却感闻闻名,并通常用于药用和化妆品,如药用和药用和药剂,如药膏和奶油,因其止痛剂和防炎特性. (+)-Camphor在乙醇和乙醇等有机溶剂中可溶解,但水溶性有限,在室温周围出现熔点,沸点要高得多,表明其挥发性.该化合物具有光学性,具有特定的旋转作用,反映其气质.除了在传统医药中的应用外,(+)-Camphor还用于各种有机化合物的合成和食品中的调味剂.安全考虑包括高剂量时可能皮肤刺激和毒性,需要小心处理和使用准则.

结构式图片

相似化合物

76-22-2 124-76-5 4695-62-9

欧盟法规

欧盟化妆品法规附录三-限用物质清单REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号464-43-7 右莰醇 | CAS号124-76-5 异龙脑 | CAS号2792-42-9 樟脑肟 | CAS号10293-06-8 D-3-溴樟脑 | CAS号405197-74-2 (1R)-isoborneol | CAS号917-54-4 甲基锂 | CAS号1034980-92-1 (R)-tert-butyl ... | CAS号32511-35-6 exo-(-)-bornylamine | CAS号32511-34-5 (R)-(+)-冰片胺 | CAS号499-75-2 香芹酚 | CAS号527-53-7 1,2,3,5-四甲基苯 | CAS号535-77-3 间伞花烃 | CAS号4501-58-0 龙脑烯醛 | CAS号75-07-0 乙醛 | CAS号51800-99-8 3-(全氟丁酰基)-(+)-樟脑 | CAS号6627-72-1 龙脑 | CAS号507-70-0 2-茨醇;冰片;龙胆

合成工艺路线路线简述

    📜Isoborneol置于cultured Cells Of Nicotiana Tabacum体系中,化学反应 240.0H,反应生成 白樟油
    参考文献:用烟草培养细胞对单环和双环单萜类化合物进行生物转化的对映选择性
    标题:用烟草培养细胞对单环和双环单萜类化合物进行生物转化的对映选择性
    摘要:研究了对薄荷烷和双环 [2.2.1] 和 [3.1.1] 庚烷衍生物的对映体对与烟草培养细胞的生物转化.发现(I)培养的细胞区分对-薄荷醇-2-醇和双环[2.2.1]庚烷-2-醇和双环[3.1.1]庚烷-3-醇衍生物的对映异构体,并对映选择性转化将这些醇转化为相应的酮,(II) 细胞高度还原 P-Menthan-2-One 衍生物的羰基,但不还原 P-Menthan-3-Ones 的羰基,以及 (Iii) 细胞区分双环[3.1.1]Hept-2-En-4-One(verbenone)的对映异构体,并对映选择性还原(1S,5S)-对映异构体的c-C双键.
    DOI:10.1246/bcsj.61.869

    海关参考信息

    专利信息


    专利号:US-6730790-B2
    优先权日:2002-03-01
    标 题:Chlorinated heterocyclic compounds and methods of synthesis
    发明人:KWIATKOWSKI STEFAN; GOLINSKI MIROSLAW
    权利人:R T ALAMO VENTURES I LLC
    摘要:Compositions of the present invention comprise chlorinated heterocyclic compounds, including racemic monochloroflosequinan, purified enantiomers of monochloroflosequinan and the sulfone derivative of monochloroflosequinan. The methods of the present invention comprise the synthesis of racemic monochloroflosequinan and derivatives thereof, including the sulfone derivative. Intermediates in the synthesis are also provided. The methods further comprise the synthesis of enantiomers of monochloroflosequinan.

    专利号:US-7230119-B2
    优先权日:2004-08-25
    标 题 :Process for the preparation of substituted pyrrolidine derivatives and intermediates
    发明人:CHAND POORAN; EL-KATTAN YAHYA; KOTIAN PRAVIN L
    权利人:BIOCRYST PHARM INC
    摘要:Two syntheses are provided; one for the preparation of (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol, and other for the preparation of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol. (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is prepared using the achiral ylide prepared from benzylamine instead of phenethylamine (Scheme 3) which provides a crystalline intermediate. The synthesis of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is achieved from (S)-diethylmalate as described in Scheme 4. A process for preparing camphor sultam is also provided.

    专利号:WO-2004074215-A1
    优先权日:2003-02-03
    标 题 :Process for preparation of clopidogrel, its salts and pharmaceutical compositions
    发明人:NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI
    权利人:NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI
    摘要:The invention discloses an improved process for racemization of methyl (R)­(-) alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate , a stereoisomer formed in the synthesis of clopidogrel i.e. methyl (S)-(+)-alpha­ (2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate or its salts. The invention is also for an improved process for production of clopidogrel or its pharmaceutically acceptable salts. The invention further discloses novel clopidogrel salts and pharmaceutical compositions comprising them.

    专利号:US-2011002837-A1
    优先权日:2009-12-17
    标 题:Enhancement of quality and quantity of carbon nanotubes during growth by addition of miscible oxygenates
    发明人:MAGHREBI MORTEZA; KHODADADI ABBASALI; MORTAZAVI YADOLLAH; SANE ALI
    权利人:MAGHREBI MORTEZA; KHODADADI ABBASALI; MORTAZAVI YADOLLAH; SANE ALI
    摘要:Disclosed is an experimental setup for synthesis of carbon nanotubes by floating catalyst method which comprises of a feeding and a reactor system. FIG. 1, illustrates CNT growth apparatus set up 100. The feeding system includes a syringe pump 115 for injecting of feed solution, liquid spraying, and or solid sublimation. The reactor system has a centrally located tubular quartz furnace 105, having a diameter of about 21.7 mm and divided into two zones.

    专利号:US-10087136-B2
    优先权日:2016-01-26
    标 题 :Process for the preparation of Metaraminol
    发明人:BRENNA DAVIDE; MARCHESI ANDREA; MIHALI Voichita
    权利人:LABORATORI ALCHEMIA S R L
    摘要:Object of the invention is a process for the preparation of Metaraminol and the salts thereof, in particular its pharmaceutically acceptable salts, especially Metaraminol bi-L-tartrate. Object of the invention is also the use of a novel catalyst and a novel ligand for the synthesis of Metaraminol and its salts.

    专利号:US-2021238374-A1
    优先权日:2020-02-04
    标 题 :Templated synthesis of nanovoided polymers
    发明人:YE SHENG; LANDIG RENATE EVA KLEMENTINE; DIEST KENNETH ALEXANDER; OUDERKIRK ANDREW JOHN; BOWMAN CHARLES ROBERT; BOWMAN ROBERT G; HENDRICKSON WILLIAM ARTHUR; RUEB CHRISTOPHER J; PURVIS II LAFE JOSEPH; SUN WENMO; LI RYAN; YAROSHCHUK OLEG; RAO TINGLING; BOROMAND ARMAN; ZHAO CHURNING; Khaleghimeybodi Morteza
    权利人:FACEBOOK TECH LLC
    摘要:A method of forming a voided polymer includes forming a polymerizable composition containing a polymer precursor and a solid templating agent, forming a coating of the polymerizable composition, processing the coating to form a cured polymer material having a solid phase in a plurality of defined regions, and removing at least a portion of the solid phase from the cured polymer material to form a voided polymer layer.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Cordoba Torres IT, Marino-Nieto J, Barkin HB, Fort AC, Cobas M. Vicks® VapoRub™ intoxication: An unusual presentation of multiorgan failure. J Clin Anesth. 2018 May 7;48:46-47. doi: 10.1016/j.jclinane.2018.04.017. [Epub ahead of print] doi: 10.1016/j.micpath.2018.04.033. [Epub ahead of print] doi: 10.1364/OE.25.002983. doi: 10.1098/rsos.171424. eCollection 2018 Feb.
    8: Cabrera-Peralta J, Peña-Alvarez A. Simple method for the determination of personal care product ingredients in lettuce by ultrasound-assisted extraction combined with solid-phase microextraction followed by GC-MS. J Sep Sci. 2018 Feb 19. doi: 10.1002/jssc.201701244. [Epub ahead of print] doi: 10.1039/c7an01855j. doi: 10.1016/j.phytochem.2018.01.014. Epub 2018 Feb 6. eCollection 2017.
    12: Coffinet M, Behr JB, Jaroschik F, Harakat D, Vasse JL. Single or Synergistic Kinetic Resolutions of Chiral Allylalanes: Two Complementary Routes for the Asymmetric Synthesis of Syn Homoallylamines. Org Lett. 2017 Dec 15;19(24):6728-6731. doi: 10.1021/acs.orglett.7b03455. Epub 2017 Dec 6. doi: 10.1016/j.aca.2017.09.047. Epub 2017 Oct 15. doi: 10.1016/j.micpath.2017.11.004. Epub 2017 Nov 7. doi: 10.1142/S0192415X1750094X. Epub 2017 Nov 9. pii: E2280. doi: 10.3390/ijms18112280.

    合成参考文献


    摘要:Kostikov, R.; Baird, M. S., Science of Synthesis, (2009) 48, 623.
    摘要:Balaban, A. T.; Balaban, T. S., Science of Synthesis Knowledge Updates, (2013) 3, 179.
    摘要:Galczynski, J.; Huang, H.; Lambert, T. H., Science of Synthesis: Special Topics, (2021) 1, 345.
    摘要:Shika Gakuho. Journal of Dentistry., 75(934), 1975 []
    摘要:Ueber die Pharmakologische Wirkung eines dem Pentamethylentetrazol, -(-), 1934
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