CAS: 36315-01-2; 2-Amino-4,6-Dimethoxypyrimidine

相似化合物

155-90-8 66131-71-3 85346-72-1

上下游产品

2-Amino-4,6-dichloropyrimidine sodium methylate diazomethane 2-aminopyrimidine-4,6-diol sulphadimethoxine N-(4,6-dimethoxy-pyrimidin-2-yl)-benzenesulfonamide4-acetylamino-N-(4,6-dimethoxy-pyrimidin-2-yl)-benzenesulfonamide 2-chloro-N-(4,6-dimethoxy-pyrimidin-2-yl)acetamide 2-amino-4,6-dimethoxy-5-nitrosopyrimidine

在 盐酸体系中,用 水 用作溶剂,化学反应 4.0H,以91.3%的收率获得2-氨基-4,6-二甲氧基嘧啶
参考文献:一种2-氨基-4,6-二甲氧基嘧啶的制备方法
标题:一种2-氨基-4,6-二甲氧基嘧啶的制备方法
摘要:本发明提供一种2‑氨基‑4,6‑二甲氧基嘧啶的制备方法.以丙二酸二酯(ⅱ)和二取代基甲叉基胍盐(ⅲ)为原料,于碱作用下进行环合反应,然后和甲基化试剂进行甲基化反应制备2‑二取代基甲叉基氨基‑4,6‑二甲氧基嘧啶(ⅳ),再于酸性水溶液中水解制备2‑氨基‑4,6‑二甲氧基嘧啶(I).本发明方法所用原料廉价易得,成本低;制备方法简单,步骤少,条件易于实现,操作安全性好;产物收率和纯度高,废水产生量少,绿色环保,适合工业化生产.

专利信息

专利号:WO-9931124-A1
优先权日:1997-12-12
标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides
发明人：HOEEG-JENSEN THOMAS
权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS
摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:JP-2002521372-A
优先权日:1998-07-23
标 题 :Process for the preparation of 4,6-disubstituted 2-isocyanatopyrimidines and their use as intermediates for the synthesis of active compounds

专利号:JP-2000281611-A
优先权日:1999-03-30
标 题 :Synthesis of phenolic compound having protected hydroxy group, and radioactive ray-sensitive composition by using the same