CAS: 3347-90-8; (S)-2-Hydroxybutanoic Acid

该化合物是一种具有分子式C4H8O3的手性氢氧化酸,作为2-氢氧丁酸的(S)-抗生素,它是有机合成和制药应用中有价值的中间体,其立体特性使其在不对称合成和光活化合物生产中特别有用.该化合物在水和极有机溶剂中表现出良好的溶解性,有助于将其纳入反应系统.其氢氧和碳化物功能组可以进行多用途衍生,使精细化学品,农用化学品和特殊材料的使用成为可能.2S)配置确保与生物系统的兼容性,使其与生物化学研究和药物开发相关.由于其酸性,建议适当处理.

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L-2-aminobutyric acid ethyl (2S)-2-acetoxybutanoate 2-Hydroxybutanoic acid (S)-2-Amino-3-methyl-butyric acid (S)-1-carboxy-propyl ester methyl (S)-2-hydroxybutyrate (S)-2-chlorobutyric acid (2R)-2-bromobutanoic acid ethyl (2S)-2-hydroxybutanoate

合成工艺路线路线简述

    1,2-丁二醇置于α-Ketoglutarate Monoammonium Salt,β-烟酰胺腺嘌呤二核苷酸,1,4-二巯基-2,3-丁二醇体系中,化学反应生成 S-2-羟基丁酸
    参考文献:Enantioselective Oxidation Of 1,2-Diols To L-.Alpha.-Hydroxy Acids Using Co-Immobilized Alcohol And Aldehyde Dehydrogenases As Catalysts
    标题:Enantioselective Oxidation Of 1,2-Diols To L-.Alpha.-Hydroxy Acids Using Co-Immobilized Alcohol And Aldehyde Dehydrogenases As Catalysts
    摘要:
    DOI:10.1021/jo00211A046

    海关参考信息

    专利信息


    专利号:US-4841045-A
    优先权日:1985-03-12
    标 题 :Synthesis of vinblastine and vincristine type compounds
    发明人:KUEHNE MARTIN
    权利人:UNIV VERMONT
    摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

    专利号:US-4897477-A
    优先权日:1985-03-12
    标题:Synthesis of vinblastine and vincristine type compounds
    发明人:KUEHNE MARTIN
    权利人:UNIV VERMONT
    摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

    专利号:US-3929796-A
    优先权日:1974-08-02
    标 题:Synthesis of penniclavine and elymoclavine
    发明人:KORNFELD EDMUND C; BACH NICHOLAS J
    权利人:LILLY CO ELI
    摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.

    专利号:US-6469133-B2
    优先权日:1999-12-13
    标题 :Process for the preparation of polymers of dimeric cyclic esters
    发明人:BAKER GREGORY L; SMITH III MILTON R
    权利人:UNIV MICHIGAN STATE
    摘要:The present invention provides a process for the direct synthesis of high melting polymers made from dimeric cyclic esters. In particular, the present invention provides a process for synthesis of polylactic acid (PLA) from racemic materials such as racemic lactide and polymandelide from mandelide. The process further provides racemic metal organic ligand catalysts such as racemic salbinap that catalyzes the polymerization of racemic dimeric cyclic ester monomers to a polylactide stereocomplex. Polymandelide and mixed dimeric cyclic esters are also prepared in the presence of low amounts of water.

    专利号:US-2017198027-A1
    优先权日:2012-01-31
    标 题:Process of afod and afcc and manufacturing and purification processes of proteins
    发明人:HOANG KIEU
    权利人:HOANG KIEU
    摘要:Manufacturing and purification processes of proteins, KH 1-through KH-52, and more KH proteins are being discovered in good healthy cells—named KH CELLS. KH CELLS are good healthy cells in which the RNA synthesizes good proteins that: 1) Send signal to the damaged, sick, and bad cells that triggers that synthesis of good proteins that transform these cells to become GOOD healthy cells; 2) Send signal to the other currently undamaged cells to synthesis of good proteins to protect them from being damaged, infected and prone to DNA and other cellular alterations; and 3) Send signal to the body to produce new cells that are healthy and forbid them from being affected by intra- and extracellular damaging signals. The mechanism that governs these processes is that the KH good healthy cells provide innate good signals that make good proteins to boost the immune system.

    专利号:US-6288244-B1
    优先权日:1999-03-31
    标 题 :Process for the preparation of 3, 4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars
    发明人:HOLLINGSWORTH RAWLE I
    权利人:UNIV MICHIGAN STATE
    摘要:A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-γ-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process relates to the synthesis of (R)-3,4-dihydroxybutanoic acid and (R)-3-hydroxy-γ-butyrolactone from a 3-leaving group substituted L-pentose sugars. The process uses a base and a peroxide to convert the pentose source to the chiral 3,4-dihydroxybutanoic acid compound. The chiral 3,4-dihydroxybutanoic acid can be further converted to 3-hydroxy-γ-butyrolactone by acidification. The chiral compound is useful as a chemical intermediate to the synthesis of various drugs and other products.
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    主要参考文献

    [参考文献]: André P Sousa, Et Al.Which Role Plays 2-Hydroxybutyric Acid On Insulin Resistance Metabolites. 2021 Dec 3;11(12):835.

    合成参考文献


    摘要:Faber, K.; Glueck, S. M., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 427.
    摘要:Ewing, T. A.; Fraaije, M. W.; van Berkel, W. J. H., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 167.
    摘要:Hollmann, F., Science of Synthesis Knowledge Updates, (2021) 3, 437.
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