CAS: 332-80-9; H-His(1-Me)-Oh

该化合物是具有不同特性的手性氨基酸衍生物,具有很高的纯度,确保可靠的分析结果.它独特的甲基组别提高了溶性性和稳定性,使其在生化研究和药物开发中的各种应用都具有理想性.该化合物的性能对于生物研究至关重要,因为它模仿了蛋白质中发现的天然氨基酸.

结构式图片

相似化合物

84030-19-3 109425-51-6 98929-98-7

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合成工艺路线路线简述

    N(α)-Benzyloxycarbonyl-N(τ)-Tert-Butyloxycarbonyl-L-Histidine Methyl Ester 以 二氯甲烷 用作溶剂,化学反应 4.0H,反应生成1-甲基-L-组氨酸
    参考文献:Colombo,Roberto; Colombo,Fabio; Derome,Adrew E.,Journal Of The Chemical Society. Perkin Transactions I,1985,P. 1811-1816
    标题:Colombo,Roberto; Colombo,Fabio; Derome,Adrew E.,Journal Of The Chemical Society. Perkin Transactions I,1985,P. 1811-1816

    海关参考信息

    专利信息


    专利号:WO-9312076-A1
    优先权日:1991-12-13
    标题:Reagents for automated synthesis of peptide analogs
    发明人:WEBB THOMAS ROY
    权利人:CORVAS INT INC
    摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

    专利号:US-5283293-A
    优先权日:1990-12-14
    标 题:Reagents for automated synthesis of peptide analogs
    发明人:WEBB THOMAS R
    权利人:CORVAS INC
    摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

    专利号:US-5367072-A
    优先权日:1990-12-14
    标 题 :Reagents for automated synthesis of peptide analogs
    发明人:WEBB THOMAS R
    权利人:CORVAS INT INC
    摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

    专利号:US-8835477-B2
    优先权日:2009-10-06
    标题 :Method for the synthesis of 2-thiohistidine and the like
    发明人:ERDELMEIER IRÈNE; DAUNAY SYLVAIN
    权利人:ERDELMEIER IRÈNE; DAUNAY SYLVAIN; TETRAHEDRON
    摘要:Methods for the synthesis of 2-thiohistidine or a derivative thereof of the formula (I), or of a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, from a compound of the formula (II) or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, by cleavage reaction in the presence of a thiol at a temperature higher than or equal to 60° C. The invention also relates to compounds of the formula (II) and a method for the synthesis thereof.

    专利号:US-8546532-B2
    优先权日:2008-04-17
    标题:Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
    发明人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS
    权利人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS; DECLION PHARMACEUTICALS INC
    摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

    专利号:US-10087221-B2
    优先权日:2013-03-21
    标题 :Synthesis of hydantoin containing peptide products
    发明人:HENKEL BERND
    权利人:SANOFI AVENTIS DEUTSCHLAND
    摘要:The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.
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    主要参考文献

    [参考文献]: Sjölin J, Et Al. Urinary Excretion Of 1-Methylhistidine: A Qualitative Indicator Of Exogenous 3-Methylhistidine And Intake Of Meats From Various Sources. Metabolism. 1987 Dec;36(12):1175-84.
    [参考文献]: C S Shin, Et Al. Serum 8-Hydroxy-Guanine Levels Are Increased In Diabetic Patients. Diabetes Care. 2001 Apr;24(4):733-7.
    [参考文献]: J R Bales, Et Al. Use Of High-Resolution Proton Nuclear Magnetic Resonance Spectroscopy For Rapid Multi-Component Analysis Of Urine. Clin Chem. 1984 Mar;30(3):426-32.
    [参考文献]: Jaime Guevara-Aguirre, Et Al. Comparison Of Oral Insulin Spray And Subcutaneous Regular Insulin At Mealtime In Type 1 Diabetes. Diabetes Technol Ther. 2007 Aug;9(4):372-6.
    [参考文献]: Kathleen M Dungan, Et Al. 1,5-Anhydroglucitol And Postprandial Hyperglycemia As Measured By Continuous Glucose Monitoring System In Moderately Controlled Patients With Diabetes. Diabetes Care. 2006 Jun;29(6):1214-9.

    合成参考文献


    摘要:
    参考文献:10.1186/1477-7819-10-271
    摘要:Davis VW, Schiller DE, Eurich D, Sawyer MB. Urinary metabolomic signature of esophageal cancer and Barrett’s esophagus. World Journal of Surgical Oncology. 2012 Dec 15;10(1):271. doi: 10.1186/1477-7819-10-271.
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