CAS: 27127-62-4; Viscosin
- 英文名称Viscosin
- 中文名称(4R)-5-[[(3S,6R,9S,12R,15S,18R,21S)-6,12-二(羟甲基)-9,15-二异丁基-18-异丙基-22-甲基-2,5,8,11,14,17,20-七羰基-3-仲-丁基-1-氧杂-4,7,10,13,16,19-六氮杂环二十二碳-21-基]氨基]-4-[[(2S)-2-(3-羟基壬酰氨基)-4-甲基-戊酰基]氨基]-5-o
- IUPAC名称(R)-5-(((3S,6R,9S,12R,15S,18R,21R,22R)-3-((S)-sec-butyl)-6,12-bis(hydroxymethyl)-9,15-diisobutyl-18-isopropyl-22-methyl-2,5,8,11,14,17,20-heptaoxo-1-oxa-4,7,10,13,16,19-hexaazacyclodocosan-21-yl)amino)-4-((S)-2-((R)-3-hydroxydecanamido)-4-methylpentanamido)-5-oxopentanoic acid
- 其它别名(4R)-4-[[(3S,6R,9S,12R,15S,18R,21R,22R)-3-[(2S)-Butan-2-Yl]-6,12-Bis(H Ydroxymethyl)-22-Methyl-9,15-Bis(2-Methylpropyl)-2,5,8,11,14,17,20-Hep Taoxo-18-Propan-2-Yl-1-Oxa-4,7,10,13,16,19-Hexazacyclodocos-21-Yl]Carb Amoyl]-4-[[(2S)-2-[[(3R)-3-Hydroxydecanoyl]Amino]-4-Methyl-Pentanoyl]A Mino]Butanoic Acid; Viscosin; (-)-N-[n-[(R)-3-Hydroxydecanoyl]-L-Leu-D-Glu-]Cyclo(D-Athr*-D-Val-L-Leu-D-Ser-L-Leu-D-Ser-L-Ile-); L-Isoleucine, N-[(2R)-3-Hydroxy-1-Oxodecyl]-L-Leucyl-D-α-Glutamyl-D-Allothreonyl-D-Valyl-L-Leucyl-D-Seryl-L-Leucyl-D-Seryl-, (9→3)-Lactone
- CAS编号27127-62-4
- FDA UNII编号:085QZ2A9M9
- 分子式:C54H95N9O16分子量:1126.4
- 产品CID: 1250986
- 产品分类有机原料 → 有机酸及其衍生物 → 肽模拟物
物理性质
- 熔点294-295 °C (分解)
- 沸点1431.2±65.0 °C(预测)
- 闪点819.3°C
- 密度1.22±0.1 g/cm3(预测)
- PH:D29 -168.3° (ethanol)
- pKa:4.43±0.10(预测)
- LogP:5.1
- 折射率1.549
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用VISCOSIN,一种由PSEUDOMONAS 荧光球和相关物种生产的环状脂质,具有强大的生物表面活性特性和植物毒性特性,在微摩尔浓度下,将表面张力从~70毫牛/米降低到30毫牛的以下30毫奈/米,促进微生物机能和生物膜的分散.VISCOSIN还表现出强烈的抗风药性活动;例如,它抑制FUSIRO 氧气球和RHIZOCTONIA SOLANI在20-50微米的浓度下在体外生长.在植物系统中,粘胶素作为植物致病介质,在24-48小时内在10-25微克/毫拉低剂量的剂量下,诱导豆类和烟草植物和烟草厂出现坏坏性损伤和叶化.此外,粘粘胶能调节宿主的免疫反应,并干扰植物-微生物相互作用中的法定人数感.
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2909110000-乙醚
2912110000-甲醛
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供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Bonnichsen L, Bygvraa Svenningsen N, Rybtke M, de Bruijn I, Raaijmakers JM, Tolker-Nielsen T, Nybroe O. Lipopeptide biosurfactant viscosin enhances dispersal of Pseudomonas fluorescens SBW25 biofilms. Microbiology. 2015 Dec;161(12):2289-97. doi: 10.1099/mic.0.000191. Epub 2015 Sep 28.
2: Geudens N, Nasir MN, Crowet JM, Raaijmakers JM, Fehér K, Coenye T, Martins JC, Lins L, Sinnaeve D, Deleu M. Membrane Interactions of Natural Cyclic Lipodepsipeptides of the Viscosin Group. Biochim Biophys Acta Biomembr. 2017 Mar;1859(3):331-339. doi: 10.1016/j.bbamem.2016.12.013. Epub 2016 Dec 20. e5. doi: 10.1016/j.cub.2019.01.050. Epub 2019 Feb 28. doi: 10.1007/s00253-014-6054-3. Epub 2014 Sep 14.
5: Saini HS, Barragán-Huerta BE, Lebrón-Paler A, Pemberton JE, Vázquez RR, Burns AM, Marron MT, Seliga CJ, Gunatilaka AA, Maier RM. Efficient purification of the biosurfactant viscosin from Pseudomonas libanensis strain M9-3 and its physicochemical and biological properties. J Nat Prod. 2008 Jun;71(6):1011-5. doi: 10.1021/np800069u. Epub 2008 May 10. doi: 10.1002/cbic.201402389. Epub 2014 Nov 7. doi: 10.1038/s41598-019-39583-7.
合成参考文献
参考文献:10.1007/s00248-011-9885-9
摘要:Rokni-Zadeh H, Mangas-Losada A, De Mot R. PCR detection of novel non-ribosomal peptide synthetase genes in lipopeptide-producing Pseudomonas. Microb Ecol. 2011 Nov;62(4):941–7. doi: 10.1007/s00248-011-9885-9.
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