CAS: 2565-58-4; (Chloromethyl)Phosphonic Acid

上下游产品

CAS号1983-26-2 氯甲基膦酸二氯 | CAS号186581-53-3 重氮甲烷 | CAS号60-29-7 乙醚 | CAS号2155-78-4 dichloro(chloro... | CAS号1898-63-1 [2-[bis(phospho... | CAS号993-13-5 甲基膦酸 | CAS号1429-50-1 乙二胺四亚甲基膦酸 | CAS号35404-71-8 methylaminometh... | CAS号18299-54-2 乙二胺盐酸盐 | CAS号2617-47-2 羟甲基磷酸 | CAS号60558-59-0 anilinomethylph...

羟甲基膦酸二甲酯置于盐酸体系中,用 水,甲苯 用作溶剂,以96.63%的收率获得氯甲基磷酸
参考文献:一种制备氯甲基膦酸的工艺方法
标题:一种制备氯甲基膦酸的工艺方法
摘要:本发明公开了一种制备氯甲基膦酸的工艺方法,包括以下步骤:S1:向反应容器中依次加入溶剂和盐酸,搅匀;S2:向其中加入羟甲基膦酸二酯,搅匀,得到反应液;S3:将所述反应液冷却,减压将所述反应液蒸干,所得残余物中加入盐酸,静置后冻干,得到氯甲基膦酸.其原料安全易得,工艺安全性高,废料少,产品纯度高.

专利信息

专利号:US-9676799-B2
优先权日:2012-07-17
标 题 :Method for the synthesis of N-(phosphonomethyl)glycine
发明人：BURCK SEBASTIAN; BRUYNEEL FREDERIC; NOTTE PATRICK
权利人:STRAITMARK HOLDING AG
摘要:A method for the synthesis of N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters, or its phosphonate ester salts, which includes the steps of: a) forming, in the presence an acid catalyst, a reaction mixture having 2,5-diketopiperazine, formaldehyde and a compound including one or more P-0-P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and the other P atom at the oxidation state (+III) or (+V), to form N,N′-bisphosphonomethyl-2,5-diketopiperazine, its mono- to tetra phosphonate esters, the dehydrated forms of N,N′-bisphosphonomethyl-2,5-diketopiperazine and the phosphonate esters of its dehydrated forms; and b) hydrolyzing the N,N′-bisphosphonomethyl-2,5-diketopiperazine, its dehydrated forms or their phosphonate esters to obtain N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters and its phosphonate ester salts.

专利号:US-2018111938-A1
优先权日:2015-05-05
标 题:Synthesis of Intermediates Used in the Manufacture of Anti-HIV Agents
发明人：PRADHAN BRAJA SUNDAR; AMARNATH KOMMIREDDY; VEMPALA NARESH; RAHMAN MD ATAUR
权利人:CBZ INVEST LTD
摘要:The present invention relates to a process of preparing intermediates of Formula (I). The process comprises of reacting compound of Formula (III) with compound of Formula (V) in the presence of a solvent selected from an alcohol, ether or water to form compound of Formula (I) wherein, R 1 is selected from —NH 2 , Cl, Br, NHCOR″, wherein R″ is alkyl, aryl, Schiff's base of formula Nâ•?CHR′, wherein R′ is alkyl or aryl; R 2 is selected from H, alkyl; R 3 and R 4 , each independently is H; R 5 and R 6 , each independently is H, alkyl; R 7 is H, alkyl; and R 8 is H, alkyl.

专利号:US-4041111-A
优先权日:1975-03-04
标题:Phosphonate monoesters and method of preparation
发明人：KELLY SUSAN J; BUTLER LARRY G
权利人:PURDUE RESEARCH FOUNDATION
摘要:Synthesis of phosphonate monoesters, as well as the use of such monoesters as substrates for enzymes which normally hydrolyze phosphodiester linkages, and a method for distinguishing between Type I and Type II phosphodiesterase enzymes using such monoesters as substrates are disclosed herein. Monoesters of phosphonic acids are prepared by the displacement of chloride from an appropriate phosphonic acid dichloride by a phenol or alcohol with pyridine as the solvent, reacting the same and then removing the solvent, after which the remaining ester chloride and dichloride are hydrolyzed by addition of water. The acid and ester are then separated and the acid-free ester is taken up in a polar organic solvent and precipitated as a salt by the addition of aqueous base, with the product then being filtered, washed with fresh acetone, dried and then stored until needed. The thus formed phosphonate monoesters are shown to be effective for use as substrate for phosphodiesterase of the Type I specificity and are shown to be ineffective for use as substrates for phosphodiesterase of the Type II specificity. The type of phosphodiesterase is therefore determined by the amount of activity against phosphonate monoesters.

专利号:US-7973109-B2
优先权日:2007-03-29
标 题 :Crosslinked type layered metal phosphonate compound, production process therefor, non-crosslinked type layered metal phosphonate compound, production process therefor, as well as stock solution
发明人：OGATA SHIN-ICHI; FUKUSHIMA YOSHIAKI; KAWASUMI MASAYA
权利人:TOYOTA CHUO KENKYUSHO KK
摘要:A process for producing a crosslinked type or non-crosslinked type layered metal phosphonate compound including a reaction step of reacting two or more members selected from organic diphosphonic acids or monophosphonic acids, or derivatives thereof having predetermined conditions and a metal source capable of forming an ion of a hexacoordinate metal atom as a central atom (M) of a metal oxide octahedron upon reaction under the presence of a sulfuric acid catalyst, a crosslinked or non-crosslinked metal phosphonate compound obtained by the process, as well as a stock solution used for the synthesis of the crosslinked or non-crosslinked type layered metal phosphonate compound described above.

专利号:US-7511113-B2
优先权日:2002-04-26
标题:Oligomeric hydroxy arylether phthalonitiles and synthesis thereof
发明人：KELLER TEDDY M; DOMINGUEZ DAWN D
权利人:US NAVY
摘要:An aromatic ether oligomer or polyaromatic ether comprising the formula:n n O—Ar n ;n nwherein Ar is an independently selected divalent aromatic radical; formed by reacting a dihydroxyaromatic with a dihaloaromatic; and wherein the reaction is performed in the presence of a copper compound and cesium carbonate. The polyaromatic ether is formed when neither the dihydroxyaromatic nor the dihaloaromatic is present in an excess amount. The aromatic ether oligomer is formed by using an excess of either dihydroxyaromatic or dihaloaromatic. A phthalonitrile monomer comprising the formula:n n nformed by reacting a 3- or 4-nitrophthalonitrile with a hydroxy-terminated aromatic ether oligomer. A thermoset formed by curing the phthalonitrile monomer. Processes for forming all the above.

专利号:YU-12877-A
优先权日:1977-01-18
标题 :Process for the synthesis of the -ethylester of chloro-methyl-phosphonic acid by means of a reduced pressure method