CAS: 23256-30-6; 3-Methyl-4-(((5-Nitrofuran-2-yl)Methylene)Amino)Thiomorpholine 1,1-Dioxide

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CAS号26494-77-9 3-methylthiomor... | CAS号698-63-5 5-硝基糠醛

📜1-[(2-羟基乙基)硫代]丙-2-醇置于磷酸 Sodium Hydroxide,肼基甲酸叔丁酯,双氧水体系中,用 乙醇,水 用作溶剂,化学反应 24.0H,反应生成硝呋替莫
参考文献:Wo2007/108947
标题:Wo2007/108947

专利信息

专利号:US-8193180-B2
优先权日:2007-01-24
标 题 :N-amino tetrahydrothiazine derivatives, method of manufacture and use
发明人：BRARD LAURENT; SINGH RAKESH KUMAR; KIM KYU KWANG; SAULNIER-SHOLLER GISELLE
权利人:BRARD LAURENT; SINGH RAKESH KUMAR; KIM KYU KWANG; SAULNIER-SHOLLER GISELLE; WOMEN & INFANTS HOSPITAL
摘要:This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufacture and use.

专利号:US-9382288-B2
优先权日:2010-10-06
标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
发明人：BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

专利号:WO-2012149093-A1
优先权日:2011-04-26
标 题 :2-guanidino-4-oxo-imidazoline derivatives as antimalarial agents, synthesis and methods of use thereof
发明人：LIN AI J; LIU XIANJUN; KOZAR MICHAEL P; O'NEIL MICHAEL T
权利人:US OF AMERICA AS REPRESENTED BY THE SECRETARY OF ARMY; LIN AI J; LIU XIANJUN; KOZAR MICHAEL P; O'NEIL MICHAEL T
摘要:The present invention relates to new 2-guanidino-4-oxo-imidazoline derivatives (deoxo-IZ), methods of making these compounds, compositions containing the same, and methods of using the same to prevent, treat, or inhibit malaria in a subject.

专利号:WO-2009026858-A1
优先权日:2007-08-28
标题 :Derivatives of acridinone as anti-parasitic, anti-fungal and anti-viral agents
发明人：PELLON CONDOM ROLANDO F; DOCAMPO PALACIOS MAITE L; PARDO ANDREU GILBERTO L; FERNANDEZ-CALIENES VALDES AYME; MENDIOLA MARTINEZ BARBARA JUDITH; ROJAS RIVERO LAZARA; D ACCORSO HAICCK NORMA BEATRIZ; FASCIO SILVA MIRTA LILIANA; DAMONTE LOTITO ELSA BEATRIZ; GARCIA CATTEBEKE CYBELE CARINA; SEPULVEDA SUCHECKI CLAUDIA SOLEDAD; MAZZUCCO GAVIEIRO MARIA BELEN; TALARICO SALINAS LAURA BEATRIZ; MAES LOUIS
权利人:CT DE QUIMICA FARMACEUTICA; PELLON CONDOM ROLANDO F; DOCAMPO PALACIOS MAITE L; PARDO ANDREU GILBERTO L; FERNANDEZ-CALIENES VALDES AYME; MENDIOLA MARTINEZ BARBARA JUDITH; ROJAS RIVERO LAZARA; D ACCORSO HAICCK NORMA BEATRIZ; FASCIO SILVA MIRTA LILIANA; DAMONTE LOTITO ELSA BEATRIZ; GARCIA CATTEBEKE CYBELE CARINA; SEPULVEDA SUCHECKI CLAUDIA SOLEDAD; MAZZUCCO GAVIEIRO MARIA BELEN; TALARICO SALINAS LAURA BEATRIZ; MAES LOUIS
摘要:The invention relates to the synthesis and evaluation of novel organic products as anti-parasitic, anti-fungal and anti-viral agents. More specifically, the invention relates to novel derivatives of 10-alyl- (I), 10-(3methyl-2-butenyl)- (II) and 10-(1,2propanodienyl)-9(10H)-acridinone (III) and a novel family of acridinones, 10-{[3-(6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-il)-4,5-dihydro-5-isoxazolyl] methyl}-9(10H) acridinone (IV) having the following formulas: wherein positions 1, 2, 3, 4, 5, 6, 7 and 8 of the acridinone ring are hydrogen atoms or halogens, groups consisting of hydroxyl, amino, nitro, alkyl with between 1 and 5 carbon atoms, trichloromethyl, trifluoromethyl, alkoxyl with between 1 and 6 carbon atoms (aryloxy substituted), aryl and alkylamino with between 1 and 6 carbon atoms (mono- and di-substituted), aryl and alkylamide with between 1 and 4 atoms of carbon, cyano, carboxyl, formyl, alkyl and arylsulfonic, mercapto substituted with alkylic chains having up to 5 carbon atoms, and sulfoxide aryl. Said derivatives have an activity against Plasmodium falciparum, Trypanosoma brucei and Trypanosoma cruzi protozoans, as well as Microsporum canis and strains of the Junin virus and Dengue.

专利号:US-6452050-B1
优先权日:1997-04-16
标 题:Synthesis and use of α-ketoamide derivatives and arrays
发明人：BALDINO CARMEN M; COFFEN DAVID L; CHIPMAN STEWART D; CHENG HONG
权利人:ARQULE INC
摘要:The invention is based on new methods for making and using compounds and arrays of novel alpha-ketoamides, and the arrays and compounds made by these methods. These novel compounds are potential inhibitors of proteolytic enzymes, particularly cysteine proteases such as cruzain. Application of the new methods has led to the identification of a number of new inhibitors, from amongst an array of about 38,000 alpha-ketoamide derivatives, having specific activity against three cysteine proteases: cruzain, papain, and cathepsin B. These compounds and other compounds identified by the methods described herein can be useful, for example, in developing pharmaceutical agents for the treatment of diseases (e.g., Chagas' disease) associated with these proteases. Although the disclosed compounds have specific activity for cruzain, papain, cathepsin B, the methods described herein can also be used to identify inhibitors of other proteases.

专利号:WO-2012149097-A2
优先权日:2011-04-26
标 题 :Guanidylimidazole and guanidylimidazoline derivatives as antimalarial agents, synthesis of and methods of use thereof