CAS: 193807-58-8; (R)-2-([1,1'-Biphenyl]-4-Ylsulfonamido)-3-Phenylpropanoic Acid
该化合物是针对MMP-2和MMP-9,外细胞基质降解和癌症转移,炎症及组织改造等病理过程的诱发酶的选择性和强效抑制剂,该复合物具有高度的特性,最大限度地减少对MMP其他家庭成员的非目标影响.其特性明确的抑制性活动使它成为研究MMP-2和MMP-9在细胞和生物化学化验中的作用的宝贵工具.抑制剂适合体外应用,为研究人员提供了调查MMP中介途径和潜在治疗干预措施的可靠手段.其稳定性和溶性确保实验环境中的一贯性能.
- 英文名称(R)-2-([1,1'-Biphenyl]-4-Ylsulfonamido)-3-Phenylpropanoic Acid
- 中文名称胶原酶
- IUPAC名称([1,1'-biphenyl]-4-ylsulfonyl)-D-phenylalanine
- 其它别名Collagenase Type Iv 72 Kda; Gelatinase, 72 Kda; Collagenase Type Iv 72 Kd; 72 Kd Gelatinase 72 Kd Type Iv Collagenase Gelatinase A; Matrix Metalloproteinase-2 Human; Proenzyme Mmp-2; Progelatinase A; Mmp-2
- CAS编号193807-58-8
- MFCD编号:MFCD02683953
- 分子式:C21H19NO4S分子量:381.45
- 产品CID: 986708
- 同类组份化合物CAS193807-58-8
- 产品分类Life Science → Amino acids → Amino acid derivatives | Inhibitors/Agonists → Protease → MMP
物理性质
上下游产品
(R)-2-(Biphenyl-4-sulfonylamino)-3-phenyl-propionic acid benzyl ester 4-diphenylsulfonyl chloride D-phenylalanine tert-butyl ester 25H27NO4SC25H27NO4S(R)-N-Benzyloxy-2-(biphenyl-4-sulfonylamino)-3-phenyl-propionamide (2R)-[(4-biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide合成工艺路线路线简述
海关参考信息
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2905121000-正丙醇
2912110000-甲醛
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主要参考文献
1. Tamura, Y., Watamane, F., Nakatani, T., et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J. Med. Chem. 41(4), 640-649 (1998). 2. Dechow, T.B., Pedranzini, L., Leitch, A., et al. Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc. Natl. Acad. Sci. USA 101(29), 10602-10607 (2004). 3. Lim, K., Hyun, Y.-M., Lambert-Emo, K., et al. Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways. Science 349(6252), (2015). 4. Mizoguchi, H., Yamada, K., and Nabeshima, T. Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer’s disease, and epilepsy.2011:681385, (2011). 5. Zeisberg, M., Khurana, M., Rao, V.H., et al. Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med. 3(4), (2006).
合成参考文献
合成方法参考DOI号:10.1002/chem.201300817
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