CAS: 18069-17-5; 2-Methylglutaricacid

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专利信息

专利号:US-12428656-B2
优先权日:2020-02-28
标题 :Nitrilase mutant and application thereof in the synthesis of 1-cyanocyclohexyl acetic acid
发明人：XUE YAPING; XIONG NENG; LI QIAN; ZHENG YUGUO
权利人:UNIV ZHEJIANG TECHNOLOGY
摘要:The present invention provides a nitrilase mutant and application thereof in the synthesis of 1-cyanocyclohexyl acetic acid, the nitrilase mutant is obtained by mutating one or two of the amino acids at position 180 and 205 of the amino acid sequence shown in SEQ ID No. 2. In the present invention, by semi-rational design and protein molecular modification, the specific enzyme activity of the nitrilase double mutant AcN-G180D/A205C was increased by up to 1.6 folds, and the conversion rate>99%. And the reaction time was shortened to a quarter of the original using the recombinant Escherichia coli containing the nitrilase mutant to hydrolyze 1-cyanocyclohexylacetonitrile at high temperature (50° C.). Therefore, the mutants obtained by the present invention have a good application prospect in efficiently catalyzing 1-cyanocyclohexylacetonitrile to synthesize gabapentin intermediate, 1-cyanocyclohexyl acetic acid.

专利号:US-2024400608-A1
优先权日:2021-09-03
标题:Synthesis of bicycle toxin conjugates, and intermediates thereof
发明人：WITTY DAVID; LIMB DARREN; MIN BYOUNG JOON; HE LIWEN; SANDERS WILLIAM J; NNANABU ERNEST OBINNA
权利人:BRICYCLETX LTD
摘要:The present invention relates to Bicycle toxin conjugates, methods for preparation, and methods of use for treating cancer.

专利号:US-4304934-A
优先权日:1980-12-30
标题 :Synthesis of amino hydroxy cyclopentenones
发明人：BARTELS-KEITH JAMES R; KARGER EVA R; ROGERS JEAN B
权利人:POLAROID CORP
摘要:This invention relates to a method of synthesizing 3-amino-2-hydroxy-2-cyclopentenones possessing an aliphatic substituent in the 4-position which comprises reacting cyanoacetamide with an aliphatic aldehyde to yield the corresponding β-substituted-α,α'-dicyanoglutaramide, hydrolyzing the amide to the corresponding β-substituted glutaric acid, esterifying the acid to the corresponding dialkyl diester, converting the diester to a 1,2-bis(trimethylsiloxy)-4-substituted cyclopentene by reductive cyclization using chlorotrimethylsilane in the presence of sodium, hydrolyzing and oxidizing the bis(trimethylsiloxy) compound to the 2-hydroxy-4-substituted-2-cyclopentenone in the presence of a cupric salt, nitrosating the 2-cyclopentenone to the 2-hydroxy-4-substituted-5-oximino-2-cyclopentenone, converting the oxime to the 2-acetoxy-3-amino-4-substituted-2-cyclopentenone by reductive acetylation and removing the acetyl group by alkanolysis to yield the 3-amino-2-hydroxy-4-substituted-2-cyclopentenone product.

专利号:US-4168280-A
优先权日:1978-05-19
标题 :Method for synthesis of 2-hydroxy-3-methyl cyclopent-2-ene-1-one
发明人：NASH WILLIAM D
权利人:EL PASO PRODUCTS CO
摘要:The known compound 2-hydroxy-3-methyl cyclopent-2-ene-1-one, used as a flavor imparting agent and commonly called maple lactone, is synthesized by a modified acyloin condensation of esters of 2-methyl glutaric acid in which oxygen is introduced in a specific manner to the reaction system.

专利号:US-2015183703-A1
优先权日:2011-03-28
标 题:Synthesis of diacids
发明人：WONG PUI KWAN; LI CHUANZHAO; STUBBS LUDGER; VAN MEURS MARTIN; ANAK KUMBANG DANIEL GAIT; LIM SHARON CHUN YAN; DRENT EITE
权利人:WONG PUI KWAN; LI CHUANZHAO; STUBBS LUDGER; VAN MEURS MARTIN; ANAK KUMBANG DANIEL GAIT; LIM SHARON CHUN YAN; DRENT EITE; AGENCY SCIENCE TECH & RES
摘要:The invention relates to a process for preparing a dicarboxylic acid comprising the steps: (a) heating a lactone in the presence of a first catalyst system to produce an alkenoic acid; and (b) contacting the alkenoic acid with carbon monoxide, water and a second catalyst system to produce a reaction composition comprising the second catalyst system and the dicarboxylic acid.

专利号:US-9102961-B2
优先权日:2009-03-11
标 题 :Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
发明人：BAYNES BRIAN M; GEREMIA JOHN MICHAEL; LIPPOW SHAUN M
权利人:CELEXION LLC
摘要:Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.