CAS: 175277-76-6; 1-(2,4-Difluorophenyl)Thiourea

该化合物是一种含氟硫尿衍生物,具有独特的结构特性,在合成化学和药用化学中具有价值;二氟苯和硫尿素的存在增强了其反应性,特别是在核生殖替代和协调化学应用中;该化合物由于具有多功能建筑构件的作用,常常被用作混合异环化合物,药物和农用化学的中间体;氟素替代物有助于改善代谢稳定性和生物活性分子的粘合性;该化合物由于对湿度和光度的潜在敏感性,通常在受控制的条件下处理.

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欧盟法规

ECHA物质C&L通报

上下游产品

2,4-difluorophenyl isothi°Cyanate N-[(2,4-difluorophenyl)carbamothioyl]benzamide 2,4-difluorophenylamine ammonium thi°Cyanate N-(2,4-difluorophenyl)thiazol-2-amine

合成工艺路线路线简述

    📜2,4-二氟异硫氰酸苯酯置于氨,水体系中,用 乙酸乙酯 用作溶剂,化学反应生成2,4-二氟苯基硫脲
    参考文献:一锅制备 氰胺 使用分子碘从二硫代氨基甲酸酯中提取
    标题:一锅制备 氰胺 使用分子碘从二硫代氨基甲酸酯中提取
    摘要:公开了一种通过使用分子碘的双脱硫策略由二硫代氨基甲酸盐合成氰胺的有效的一锅法.二硫代氨基甲酸酯,通过碘的作用异硫氰酸酯 原位,经水处理nh 3 给 硫脲.这硫脲因此生成的产物经i 2进一步氧化脱硫,从而以非常好的收率获得相应的氰酰胺.环境友好性,成本效益和高产量是这一一锅法的重要属性.
    Doi:10.1039/b914283P

    专利信息


    专利号:US-2008004415-A1
    优先权日:2004-05-03
    标题 :Non-linear optically active molecules, their synthesis, and use
    发明人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
    权利人:OPTIMER PHOTONICS INC
    摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

    专利号:US-2012059163-A1
    优先权日:2005-04-28
    标题 :Non-linear opticaly active molecules, their synthesis, and use
    发明人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
    权利人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B; OPTIMER PHOTONICS INC
    摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

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    合成参考文献


    参考文献:10.5517/ccz2rvm
    摘要:doi:10.5517/ccz2rvm
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