专利号:US-10253153-B2 优先权日:2015-04-24 标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support 发明人:MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI 权利人:NITTO DENKO CORP 摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.
专利号:US-2022356182-A1 优先权日:2009-03-27 标题 :Inhibitors of hepatitis c virus replication 发明人:COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-9834556-B2 优先权日:2014-03-24 标题 :Process of preparing 3-(3-(4-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-YL)pyridin-2-amine 发明人:BATES CRAIG; CHEN JIAN-XIE; MAO JIANMIN; REED DAVID P 权利人:ARQULE INC 摘要:The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:
专利号:US-5215997-A 优先权日:1985-09-11 标题:Synthesis of beta-lactam compounds 发明人:HUNGERBUEHLER ERNST; KALVODA JAROSLAV 权利人:CIBA GEIGY CORP 摘要:The invention relates to an improved process for the preparation of compounds of formula ##STR1## or salts thereof, starting from compounds of formulae ##STR2## via compounds of formulae ##STR3## in which compounds R 1 is hydrogen or lower alkyl, R 2 is an organic radical which may carry a functional group which may be protected by a customary protective group R 2 o , R 3 is hydrogen or a customary carboxyl protective group R 3 o , W is a group which can be replaced by a thiocarboxylic acid radical of formula III, and Z is oxygen or sulfur.
专利号:US-6333441-B1 优先权日:1992-03-09 标题:Preparation of cis—olefins 发明人:SATO FUMIE; MIYAJI KATSUAKI; AMANO TAKEHIRO 权利人:NISSAN CHEMICAL IND LTD; SATO FUMIE 摘要:A cis-olefin of the formula: R 1 —CHâ•?CH—R 2 is prepared by reducing an alkyne of the formula: R 1 —C≡C—R 2 with formic acid in the presence of a palladium catalyst. R 1 and R 2 are independently selected from the group consisting of a hydrogen atom, ester group, substituted silyl group, carboxyl group, cyano group, aliphatic C1-C20 hydrocarbon group, and phenyl group. The cis-olefin which is a useful intermediate for the synthesis of fine chemicals is selectively produced in high yields.
专利号:US-3698864-A 优先权日:1969-05-28 标题 :Synthesis of tetrafluorohydrazine 发明人:GRAKAUSKAS VYTAUTAS 权利人:AEROJET GENERAL CO 摘要:THIS PATENT DESCRIBES A NOVEL PROCESS FOR THE IN SITU PREPARATION OF TETRAFLUOROHYDRAZINE WHICH COMPRISES PASSING FLUORINE INTO AN AQUEOUS SOLUTION OF AN ALKYL CARBAMATE OF THE FORMULA: R-OOC-NH2 WHEREIN R EQUALS ALKYL, AND AN OXIDIZING AGENT, AND COLLECTING THE TETRAFLUOROHYDRAZINE REACTION PRODUCT.
摘要:Aitken, R. A.; Boubalouta, Y., Science of Synthesis Knowledge Updates, (2013) 4, 141. 摘要:Australian Journal of Experimental Biology and Medical Science., 45(507), 1967 [] 摘要:Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1982 摘要: 摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)