CAS: 16354-58-8; (S)-2-Acetamido-3-Hydroxypropanoic Acid

该化合物是一种高纯度氨基酸衍生物,具有更强的稳定性和生物利用率.它的纯度能确保最低的杂质,使其适合需要高特性和纯度的应用.该化合物在药物研究中被广泛使用,作为生物活性分子合成的前体.

结构式图片

上下游产品

CAS号56-45-1 L-丝氨酸 | CAS号108-24-7 乙酸酐 | CAS号5680-80-8 L-丝氨酸甲酯盐酸盐 | CAS号64-19-7 冰醋酸 | CAS号2311-26-4 EDTADISODIUM | CAS号75-36-5 乙酰氯 | CAS号114118-71-7 (S,E)-2-((2-ace... | CAS号5147-00-2 O-乙酰-L-丝氨酸 | CAS号56-23-5 四氯化碳 | CAS号2311-26-4 EDTADISODIUM | CAS号56-45-1 L-丝氨酸

合成工艺路线路线简述

  • 合成目标产物 N-Acetyl-L-Serine 主要起始原料 L-Serine Methyl Ester Hydrochloride And Acetic Acid
  • (文献来源)合成步骤主要原料 L-Serine Methyl Ester Hydrochloride 和 Acetic Acid
O-乙酰基-L-丝氨酸 以 水 用作溶剂,化学反应生成N-乙酰-L-丝氨酸
参考文献:Intramolecular Aminolysis Of Esters. O-Acetylserine And .Gamma.-Esters Of Glutamic Acid
标题:Intramolecular Aminolysis Of Esters. O-Acetylserine And .Gamma.-Esters Of Glutamic Acid
摘要:
Doi:10.1021/jo00321A011

海关参考信息

专利信息


专利号:US-3846399-A
优先权日:1969-04-10
标题:Process for controlled stepwise synthesis of polypeptides
发明人:HIRSCHMANN R; DENKEWALTER R
权利人:MERCK & CO INC
摘要:The invention disclosed herein relates to a novel process for the controlled, stepwise synthesis of polypeptides and proteins. More particularly, it is concerned with a process for the rapid and efficient preparation of polypeptides in which multiple sequential steps are carried out without isolation of intermediate peptides. This process for the controlled stepwise synthesis of polypeptides involves reacting a starting amino acid or peptide (or derivative thereof) with an N-carboxy amino acid anhydride (or derivative thereof) in an aqueous medium under conditions of controlled pH such that the only amino group present in appreciable concentration in reactive form during the course of the reaction is the amino group in the starting amino acid or peptide.

专利号:US-2004175710-A1
优先权日:2001-05-22
标题:Method for in situ, on-chip chemical synthesis
发明人:HAUSHALTER ROBERT C
摘要:Apparatus and methods for the synthesis of arrays of molecules bound to a substrate, and in particular oligomeric molecules such as DNA oligonucleotides and peptides. The methods of the invention comprise providing a substrate having first and second surfaces and a plurality of isolated porous regions extending through the substrate and communicating with the first and second surfaces, contacting selected ones of the porous regions with a reagent, allowing the reagent to bind to or otherwise interact with the selected porous regions, and withdrawing unreacted first reagent from the substrate through the selected porous regions by introducing a pressure differential across the substrate. The events may be repeated as required to form oligomeric molecules.

专利号:US-5919523-A
优先权日:1995-04-27
标题:Derivatization of solid supports and methods for oligomer synthesis
发明人:SUNDBERG STEVEN A; JACOBS JEFFREY W; SCHULLEK JOHN R; MCGALL GLENN H; MIRZABEKOV ANDREI; TIMOFEEY EDWARD; FUJIMOTO DAVID; HOLMES CHRISTOPHER P; YANG HUA
权利人:AFFYMETRIX INC
摘要:Methods and derivatized supports which are useful in solid-phase synthesis of peptides, oligonucleotides or other small organic molecules as well as arrays of ligands. The methods provide means to control the functional site density on a solid support. Some of the derivatized supports are polymer-coated or glycan-coated. Other methods for regenerating the surface of a used ligand array are also provided.

专利号:US-8580542-B2
优先权日:2011-02-10
标 题 :Methods and compositions for producing alkenes of various chain length
发明人:RIDLEY CHRISTIAN P
权利人:RIDLEY CHRISTIAN P; JOULE UNLTD TECHNOLOGIES INC
摘要:The NonA alkene synthase in Synechococcus sp. displays selective synthesis of 1-nonadecene. Heterologous recombination of a domain, i.e. the acyl binding domain, with other acyl binding proteins, affects acyl substrate chain-length binding selectivity and therefore the chain-length of the synthesized 1-alkenes. Compositions and methods are provided to selectively synthesize 1-alkenes of various chain lengths.

专利号:US-9528127-B2
优先权日:2013-01-25
标 题:Recombinant synthesis of medium chain-length alkanes
发明人:SKRALY FRANK ANTHONY; LI NING
权利人:JOULE UNLIMITED TECH INC; JOULE UNILIMITED TECH INC
摘要:The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently produce alkanes, and in particular the use of such organisms for the commercial production of alkanes and related molecules. Other materials, methods, and compositions are also described.

专利号:US-5783674-A
优先权日:1989-02-17
标 题 :Method for the use and synthesis of peptides
发明人:GEYSEN HENDRIK MARIO
权利人:CHIRON CORP
摘要:A method for the separation of at least one specific binding entity from a mixture of binding entities by the steps of contacting a mixture of binding entities with immobilized peptides in which the peptides specifically bind to the specific binding entities and the peptides contain an amino acid which facilitates removal of the binding entities from the peptides, and separating the immobilized peptide/specific binding entity complexes from the mixture of binding entities. A change in incubation conditions facilitates removal of the binding entities from the immobilized peptides.
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合成参考文献


参考文献:10.1021/bi200813s
摘要:Lewis CA, Wolfenden R. Amide bonds to the nitrogen atoms of cysteine and serine as "weak points" in the backbones of proteins. Biochemistry. 2011 Aug 23;50(33):7259–64. doi: 10.1021/bi200813s.
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