CAS: 15813-09-9; 4,5-Diiodo-1H-Imidazole

相似化合物

71759-89-2 1746-25-4 73746-44-8

上下游产品

CAS号288-32-4 咪唑 | CAS号3034-50-2 4-咪唑甲醛 | CAS号1746-25-4 2,4,5-三碘-1H-咪唑 | CAS号37067-96-2 4,5-二碘-1-甲基-1H-咪唑 | CAS号668-94-0 4,5-二苯基咪唑 | CAS号670-95-1 4-苯基咪唑 | CAS号71759-89-2 4-碘咪唑 | CAS号35681-63-1 1H-Imidazole,5-... | CAS号76529-47-0 1H-Imidazole,4-... | CAS号198127-92-3 N,N-二甲基-4,5-二碘-... | CAS号536760-31-3 1-benzyl-4,5-di...

咪唑置于sodium Hydroxide,碘,Potassium Iodide体系中,用 水 用作溶剂,以90%的收率获得4,5-二碘咪唑
参考文献:通过碘-铜交换反应对咪唑进行选择性官能化.
标题:通过碘-铜交换反应对咪唑进行选择性官能化.
摘要:受保护的4,5-二碘咪唑与(phme2Cch2)2Culi的区域选择性反应可生成5-杯化的咪唑,该咪唑易于与各种亲电试剂反应,以高收率提供官能化的咪唑;值得注意的是,这些所得的单碘咪唑在诸如醛或酮的敏感官能团的存在下再次进行碘-铜交换反应.
Doi:10.1039/b603419E

专利信息

专利号:US-10226434-B2
优先权日:2015-01-30
标题:Design, synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity
发明人：RADTKE KATHERINE L; PETERS HANNAH; NEYTS JOHAN; JOCHMANS DIRK; SNIJDER ERIC J
权利人:UNIV MARYLAND; KATHOLIEKE UNIV LEUVEN/LIEDEN UNIV MEDICAL CENTER RC LEIDEN
摘要:The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.

专利号:UA-68408-C2
优先权日:1998-12-23
标 题:3-azabicyclo[3.1.0]hexane derivatives as opiate receptor ligands, pharmaceutical and veterinary composition, method for treatment and method for synthesis of derivatives

专利号:US-2019201352-A1
优先权日:2015-01-30
标题 :Design, synthesis and methods of use of acyclic flexmier nucleoside analogues having anti-coronavirus activity

专利号:US-2018303768-A1
优先权日:2015-01-30
标 题 :Design, synthesis and methods of use of acyclic flexmier nucleoside analogues having anti-coronavirus activity

专利号:US-10058516-B2
优先权日:2015-01-30
标题:Design, synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity

专利号:CA-2975382-A1
优先权日:2015-01-30
标题 :Design, synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity