CAS: 154934-97-1; Ethyl 2-Oxo-6-(Trifluoromethyl)-1,2-Dihydropyrimidine-5-Carboxylate

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📜Ethyl 4,4,4-Trifluoro-3-Oxo-2-(Ureidomethylidene)Butanoate置于sodium Ethanolate体系中,用 乙醇 用作溶剂,化学反应生成2-羟基-4-三氟甲基嘧啶-5-羧酸乙酯
参考文献:Structure-activity Relationship Studies Of Ethyl 2-[(3-Methyl-2,5-Dioxo(3-Pyrrolinyl))Amino]-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate: An Inhibitor Of Ap-1 And Nf-κb Mediated Gene Expression
标题:Structure-activity Relationship Studies Of Ethyl 2-[(3-Methyl-2,5-Dioxo(3-Pyrrolinyl))Amino]-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate: An Inhibitor Of Ap-1 And Nf-κb Mediated Gene Expression
摘要:Several Analogues Of Ethyl 2-[(3-Methyl-2,5-Dioxo(3-Pyrrolinyl))Amino]-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate (1) Were Synthesized And Tested As Inhibitors Of Ap-1 And Nf-Kappab Mediated Transcriptional Activation In Jurkat T Cells. From Our Sar Work,Ethyl 2-[(3-Methyl-2,5-Dioxo(3-Pyrrolinyl))-N-Methylamino]-4-(Trifluoromethyl)-Pyrimidine-5-Carboxylate Was Identified As A Novel And Potent Inhibitor. (C) 2002 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0960-894X(02)00517-6