CAS: 153436-53-4; N-(3-Chlorophenyl)-6,7-Dimethoxyquinazolin-4-Amine

上下游产品

ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 4-chloro-1-(phenyl)-1H-pyrazolo[3,4-d]pyrimidine 3-chloro-aniline

📜5-氨基-4-乙氧羰基-1-苯基吡唑置于三氯氧磷体系中,用 异丙醇 用作溶剂,化学反应 0.75H,反应生成4-(3-氯苯胺)-6,7-二甲氧基喹唑啉盐酸盐
参考文献:Novel Dual Use Of Formamide-Pocl3 Mixture For The Efficient,One-Pot Synthesis Of Condensed 2H-Pyrimidin-4-Amine Libraries Under Microwave Irradiation
标题:Novel Dual Use Of Formamide-Pocl3 Mixture For The Efficient,One-Pot Synthesis Of Condensed 2H-Pyrimidin-4-Amine Libraries Under Microwave Irradiation
摘要:The Novel Dual Use Of Formamide-Pocl3 Mixture For The Incorporation Of A C-N Fragment To Form The Pyrimidine Nucleus And Its Subsequent Chlorination In An Efficient,One-Pot Synthesis Of Potentially Bioactive Condensed 2H-Pyrimidin-4-Amine Libraries Under Microwave Irradiation (Mwi) Is Reported. The One-Pot Microwave-Assisted Synthetic Protocol Is High-Yielding,Ecofriendly,Rapid,And Novel As Well As Eliminates Intermittent Work-Ups. The Protocol Can Be Adapted For The Library Synthesis Of Series Of A Condensed Pyrimidines.
Doi:10.1080/00397911.2011.607934

专利信息

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-12060343-B2
优先权日:2018-10-22
标题 :Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors

专利号:US-2023391751-A1
优先权日:2018-10-22
标题 :Substituted 1,2,4-triazoles as intermediates in the synthesis of tyk2 inhibitors

专利号:US-11406709-B2
优先权日:2014-09-15
标 题 :Therapeutic and research application of PDCL3
发明人：RAHIMI NADER
权利人:UNIV BOSTON
摘要:Described herein are novel compositions comprising, for example, PDCL3 polypeptides having VEGFR-2 inhibitory activity, inhibitory PDCL3 antibodies and PDCL3-binding fragments thereof, or PDCL3 inhibitory nucleic acid molecules, and methods of their use in anti-angiogenesis and anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, as well as the treatment of those vascular diseases where pathological angiogenesis plays a role, such as in carotid artery disease, macular degeneration, and plaque neovascularization. Also described herein are novel compositions comprising engineered PDCL3 polypeptides having enhanced chaperone activity, recombinant cells comprising such engineered PDCL3 polypeptides having enhanced chaperone activity, and methods thereof for therapeutic protein production and in vitro protein synthesis.

专利号:BR-112015021965-B1
优先权日:2013-03-13
标题 :Pyrrolobenzodiazepine conjugates and compounds, pharmaceutical composition, use thereof for the treatment of a proliferative disease and method of synthesis of said compounds

专利号:US-7052692-B1
优先权日:1997-09-02
标题:Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression
发明人：SRIVASTAVA ARUN; QING KEYUN; WANG XU-SHAN; PONNAZHAGAN SELVARANGAN; BAJPAI ANIL
权利人:ADVANCED RES & TECH INST
摘要:The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. More particularly, the present invention demonstrates that D-BP is phosphorylated by EGF-R protein tyrosine kinase. Methods of increasing transcription and promoting replication of transgenes exploiting this information are disclosed herein.