CAS: 15014-25-2; Dibenzyl Malonate

相似化合物

16695-14-0 1071-46-1 40204-26-0

上下游产品

diethyl malonate benzyl alcohol malonic acid benzyl bromidetrans-2-benzoyl-cycloheptyl)-malonic acid(+/-)-(trans-2-benzoyl-cycloheptyl)-malonic acid dibenzyl aminomalonate dibenzyl 2-bromomalonate 3,4,5,6-Tetra-O-acetyl-1-deoxy-D-psicose

丙二酸,苯甲醇置于硫酸体系中,用 甲苯 用作溶剂,化学反应 2.0H,以91%的收率获得二苄基马来酸酯
参考文献:Synthesis And Decarboxylation Of δ2-Cephem-4,4-Dicarboxylic Acids
标题:Synthesis And Decarboxylation Of δ2-Cephem-4,4-Dicarboxylic Acids
摘要:青霉素v经过14个步骤转化为具有c-3处氢,C-2处氢或乙基,以及c-4处两个甲氧羰基,两个苄氧羰基或一个甲氧羰基和一个苄氧羰基取代基的δ2-头孢菌素.通过碱性水解(对甲酯类)或氢解(对苄酯类)去保护这些δ2-头孢菌素-4,4-二羧酸酯,在所有情况下都导致δ2-头孢菌素-4,4-二羧酸或δ2-头孢菌素-4,4-二羧酸单酯的快速脱羧.C-2处为氢时,用1当量碱水解二甲酯酯类产生δ2-头孢菌素.用2当量碱,并且所有化合物c-2处为甲基时,水解或氢解得到4α-取代的δ2-头孢菌素. 相比之下,更简单的苄或甲基乙酰胺丙二酸酯可以轻松去保护以得到稳定的丙二酸.使用半经验(am1)和从头算(3-21G)分子轨道计算研究了脱羧难易度差异的原因.发现未离子化的头孢菌素或乙酰胺丙二酸的脱羧能垒较高(35-40 Kcal Mol-1).尽管乙酰胺丙二酸的单负离子保留了较高的能垒,但δ2-头孢菌素丙二酸的异构单负离子脱羧能垒仅为2 Kcal Mol-1.关键词:巯基氮杂环丙酮酮,溴丙二酸酯,分子轨道计算,亚氧化物,氢解.
Doi:10.1139/v01-100

专利信息

专利号:US-4288608-A
优先权日:1978-06-01
标题:Synthesis of anthracyclines
发明人：JOHNSON FRANCIS; KIM KYOUNG S
权利人:RESEARCH CORP
摘要:There is provided a novel method of synthesizing certain heterocyclic quinones. In particular there is provided a novel and regiospecific synthesis of 9-acetyl-6,11-dihydroxy-4-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-quinone (7,9-dideoxydaunomycinone) which is known intermediate in the synthesis of daunomycinone. There is also provided a method of preparing analogs of 7,9-dideoxydaunomycinone which thus provide for the preparation of known and desired analogs of daunomycinone. Daunomycinone is a known compound which is an intermediate in the preparation of the clinically accepted naturally-occurring antitumor antibiotics daunomycin and its derivitive adriamycin.

专利号:US-7384739-B2
优先权日:2001-11-14
标题 :Compositions for enhancing DNA synthesis, DNA polymerase-related factors and utilization thereof
发明人：KITABAYASHI MASAO; KUROITA TOSHIHIRO; ISHIDA YOSHIKAZU; KOMATSUBARA HIDEYUKI; NISHIYA YOSHIAKI; OKA MASANORI; KAWAMURA YOSHIHISA; IMANAKA TADAYUKI
权利人:TOYO BOSEKI
摘要:The invention provides methods, kits, and compositions for enhancing synthesis of DNA involving a carboxylate ion-supplying substance that is effective in promoting DNA synthesis in enzymatic DNA synthesis reactions. The invention further provides a thermostable DNA polymerase-related factor derived from Thermococcus species, which has an activity to promote the DNA synthesis activity of DNA polymerase or which binds to DNA polymerase.

专利号:US-8884051-B2
优先权日:2010-10-20
标题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent
发明人：MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C
权利人:MALOFSKY BERNARD M; MALOFSKY ADAM G; DEY TANMOY; SULLIVAN JEFFREY M; CHEN YANGBIN; WOJCIAK STANLEY C; COCKREM MICHAEL C; BIOFORMIX INC
摘要:The present invention provides a method of making a methylene malonate monomer that includes the steps of reacting a malonic acid ester with a source of formaldehyde optionally in the presence of an acidic or basic catalyst and optionally in the presence of an acidic or non-acidic solvent to form reaction complex. The reaction is optionally performed in the presence of or contacted with an energy transfer means such as a heat transfer agent, a heat transfer surface, a source of radiation or a laser such that reaction complex is substantially vaporized to produce a vapor phase comprising methylene malonate monomer which may be isolated. The present invention further provides methylene malonate monomers prepared by the method of the invention, as well as compositions and products formed from the methylene malonate monomers, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

专利号:WO-2024013736-A1
优先权日:2022-07-12
标题 :Process for preparing substituted benzamides
发明人：HAMIRANI BHAVINKUMAR; MAHESH GANDHAM; SREEDEVI MANNAM; PILLAI BIJUKUMAR GOPINATHAN
权利人:ADAMA MAKHTESHIM LTD
摘要:The present invention relates to new intermediates for the preparation of pyridylmethylbenzamides via substituted hydroxyiminopyridines or acetamidopyridines, and their innovative preparation processes. The invention discloses, in particular, the total synthesis of fluopicolide fungicide. The preparation of the main substances of the fluopicolide synthesis, specifically, substituted pyridine-2-ylmethanamine or its salt, is disclosed via two different synthesis routes, comprises two novel substances.

专利号:US-4196127-A
优先权日:1978-06-01
标题 :Anthracyclines
发明人：JOHNSON FRANCIS; KIM KYOUNG S
权利人:RESEARCH CORP
摘要:There is provided a novel method of synthesizing certain heterocyclic quinones. In particular there is provided a novel and regiospecific synthesis of 9-acetyl-6,11-dihydroxy-4-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-quinone (7,9-dideoxydaunomycinone) which is a known intermediate in the synthesis of daunomycinone. There is also provided a method of preparing analogs of 7,9-dideoxydaunomycinone which thus provide for the preparation of known and desired analogs of daunomycinone. Daunomycinone is a known compound which is an intermediate in the preparation of the clinically accepted naturally-occurring antitumor antibiotics daunomycin and its derivative adriamycin.

专利号:US-7371852-B2
优先权日:2003-01-22
标 题 :Alkyl-linked nucleotide compositions
发明人：HARDEMAN KLASS P; HALL STEVEN E; WARE ROY W; HINKLEY LINDSAY A; JENKS MATTHEW G
权利人:SERENEX INC
摘要:Alkyl-linked nucleotide non-homogeneous solid supports and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in the invention are methods for synthesis of an alkyl-linked nucleotide, nucleotide affinity media and methods of use thereof for affinity chromatography and screening methods.