CAS: 1474-78-8; Ethyl (Diethoxyphosphoryl)Formate

该化合物是一种多用途有机磷化合物,广泛用作有机合成的试剂,其主要优点包括它作为霍纳-沃德斯沃斯-埃蒙(HWE)试剂的作用,促进α,β-不饱和酯和其他碳基衍生物的有效形成;该化合物在发泡反应中表现出高度的回动性和选择性,使其对构建复杂的分子框架很有价值;在标准条件下的稳定性和与各种功能组的兼容性进一步提高了其在多步合成中的效用;此外,它作为磷酸盐剂和中间剂在制药和农用化学品中的前体;该乙氧碳基化合物组有助于其在普通有机溶剂中的溶解性,简化处理和反应工作.

英文名称Ethyl (Diethoxyphosphoryl)Formate
中文名称(二乙氧基磷酰基)甲酸乙酯
IUPAC名称ethyl diethoxyphosphorylformate
其它别名二乙氧基氧膦基甲酸乙酯,98%; Triethyl Phosphonoformate
CAS编号1474-78-8
MFCD编号:MFCD00009108
EINECS号:216-016-8
FDA UNII编号:TUX6M928ID
分子式:C7H15O5P分子量:210.16
产品CID: 705130
产品分类有机原料→通用试剂→wittig试剂

相似结构搜索
产品信息参考;;
InChIKey: NOJFJZZMRDSOLM-UHFFFAOYSA-N
InChI=1S/C7H15O5P/c1-4-10-7(8)13(9,11-5-2)12-6-3/h4-6H2,1-3H3
计算化学: 氢键受体数5.0氢键供体数*可旋转键数6.0

相似化合物

3084-40-0 72304-94-0 17997-33-0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
特定目标器官毒性 - 单次接触类别3
皮肤致敏类别1
严重眼刺激类别2A
警示词Warning(警告)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H335 |可能引起呼吸道刺激.
H317 |可能引起皮肤过敏反应.
防范说明P261-P264-P272-P280-P302+P352-P362+P364-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明S24/25
危险类别码R36/37/38,R43
WGK Germany3

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

📜Dimethoxymethyl Phosphonic Acid Dimethyl Ester置于n-溴代丁二酰亚胺(Nbs)体系中,用苯用作溶剂,化学反应 1.0H,以80%的收率获得甲膦酸三乙酯
参考文献:Livantsov,M. V.; Proskurnina,M. V.; Prishchenko,A. A.,Journal Of General Chemistry Of The Ussr,1984,Vol. 54,# 11,P. 2237-2249
标题:Livantsov,M. V.; Proskurnina,M. V.; Prishchenko,A. A.,Journal Of General Chemistry Of The Ussr,1984,Vol. 54,# 11,P. 2237-2249

海关参考信息

2912110000-甲醛
2915110000-甲酸
2901100000-饱和无环烃
2909199090-其他醚及其衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:EP-0479960-B1
优先权日:1990-03-12
标题:Method for the synthesis of trisodium phosphonoformate hexahydrate
发明人：JAKUPOVIC EDIB; STENHEDE URBAN
权利人:ASTRA AB
摘要:The present invention relates to a method for the synthesis of foscarnet, i.e. trisodium phosphonoformate hexahydrate, comprising the steps of adding sodium hydroxide to water, heating the aqueous sodium hydroxide solution to 50 DEG C, adding triethyl phosphonoformate to said solution at 50 DEG C, heating the reaction mixture to reflux for about 1 hour, cooling of the reaction mixture and filtering-off of the product.

专利号:US-5591889-A
优先权日:1991-03-06
标题:Method for the synthesis of trisodium phosphonoformate hexahydrate
发明人：JAKUPOVIC EDIB; STENHEDE JAN
权利人:ASTRA AB
摘要:The present invention relates to a method for the synthesis of foscarnet, i.e. trisodium phosphonoformate hexahydrate, comprising the steps of adding sodium hydroxide to water, heating the aqueous sodium hydroxide solution to 50Â° C., adding triethyl phosphonoformate to said solution at 50Â° C., heating the reaction mixture to reflux for about 1 hour, cooling of the reaction mixture and filtering-off of the product.

专利号:LT-3585-B
优先权日:1990-03-12
标题:Method for the synthesis of trisodium phosphonoformate hexahydrate

专利号:DK-0479960-T3
优先权日:1990-03-12
标题 :Process for Synthesis of Foscarnet

专利号:WO-9113894-A1
优先权日:1990-03-12
标题 :Method for the synthesis of trisodium phosphonoformate hexahydrate

专利号:GR-920300063-T1
优先权日:1990-03-12
标题:Method for the synthesis of trisodium phosphonoformate hexahydrate