专利号:US-7160517-B2 优先权日:2000-08-18 标题 :Apparatus and methods for the automated synthesis of oligosaccharides 发明人:SEEBERGER PETER H; PLANTE OBADIAH J 权利人:MASSACHUSETTS INST OF TECHNOLG 摘要:One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the present invention is used in combinatorial methods, e.g., as described herein, of synthesizing oligosaccharides.
专利号:US-11566040-B2 优先权日:2019-01-28 标题:Synthesis of O-antigen oligosaccharide compounds of Helicobacter pylori serotype O2 发明人:YIN JIAN; HU JING; LIU ZHONGHUA; QIN CHUNJUN 权利人:UNIV JIANGNAN 摘要:Disclosed is synthesis of an O-Antigen oligosaccharide compound of Helicobacter pylori serotype O2, belonging to the field of organic synthesis. The disclosure obtains O-antigen disaccharide to tetracosasaccharide of Helicobacter pylori serotype O 2 by chemical synthesis. A chemical synthesis method which is quite conducive to production of a glucose-α-lglucosidic bond is developed in the disclosure by a protectant strategy, temperature effect, solvent effect, and additive effect. The method is applied in synthesis of an O-antigen oligosaccharide compound of Helicobacter pylori serotype O2 assembled with an amino linking arm. A saccharide conjugate can be prepared from the synthesized O-antigen oligosaccharide compound of Helicobacter pylori serotype O2 assembled with an amino linking arm together with a carrier protein for immunology researches, playing an important role in preventing and treating Helicobacter pylori.
专利号:US-2022395800-A1 优先权日:2019-11-04 标题:Device for automated synthesis of oligo- and polysaccharides 发明人:SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO 权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A 摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.
专利号:WO-2022034429-A1 优先权日:2020-08-10 标 题 :PROCESS OF SYNTHESIS OF β-6'SULFOQUINOVOSYL DIACYLGLYCEROLS 发明人:MANZO EMILIANO; FONTANA ANGELO; ZIACO MARCELLO 权利人:BIOSEARCH S R L 摘要:The present invention relates to a synthesis process of β-6-sulfoquinovosyl-diacylglycerols. In particular, said process is for the synthesis of the compounds 1,2-O-distearoyl-3-O-(β- sulfoquinovosyl)- R/S -glycerol, 1,2-O-distearoyl-3-O-(β-sulfoquinovosyl)- R -glycerol or 1,2- O-distearoyl-3-O-(β-sulfoquinovosyl)- S -glycerol, named respectively Sulfavant A, Sulfavant R and Sulfavant S.
专利号:US-12281135-B2 优先权日:2019-07-25 标 题 :Synthesis of 6-azido-6-deoxy-2-n-acetyl-hexosamine-nucleoside diphosphate 发明人:HOOGENBOOM JORIN; WIJDEVEN MARIA ANTONIA; VERKADE JORGE MERIJN MATHIEU; VAN DELFT FLORIS LOUIS; VAN BERKEL SANDER SEBASTIAAN 权利人:SYNAFFIX BV 摘要:The current invention concerns methods for the synthesis of 6-azido-6-deoxy-2-N-acetyl-monosaccharide-nucleoside diphosphate, in particular 6-azido-6-deoxy-2-N-acetyl-D-galactosamine-nucleoside diphosphate or 6-azido-6-deoxy-2-N-acetyl-D-glucosamine-nucleoside diphosphate. The synthesis method according to the invention is characterized by being highly efficient and high yielding. Also part of the present invention are key intermediates of this process.
专利号:US-9938312-B2 优先权日:2011-03-25 标题 :Compounds and methods for chemical and chemo-enzymatic synthesis of complex glycans 发明人:BOONS GEERT-JAN; WANG ZHEN 权利人:BOONS GEERT JAN; WANG ZHEN; UNIV GEORGIA 摘要:The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.
摘要:Coote, S. C.; Smith, L. H. S.; Procter, D. J., Science of Synthesis Knowledge Updates, (2010) 3, 451. 摘要:Demchenko, A. V.; De Meo, C., Science of Synthesis Knowledge Updates, (2010) 3, 363.