CAS: 113211-94-2; 2,3-Difluorobenzyl Bromide

相似化合物

151412-02-1 157911-55-2 1765-40-8

上下游产品

CAS号75853-18-8 2,3-二氟苯甲醇 | CAS号4519-39-5 2,3-二氟苯甲酸 | CAS号266360-42-3 (S)-2-氨基-3-(2,3... | CAS号412950-51-7 (2,3-difluoroph...

2,3-二氟苯甲酸置于三溴化磷,Diborane(6)体系中,用 四氢呋喃,甲苯 用作溶剂,化学反应 4.5H,反应生成2,3-二氟溴苄
参考文献:9-(2-氟苄基)-6-(烷基氨基)-9H-嘌呤.一类新的抗惊厥药.
标题:9-(2-氟苄基)-6-(烷基氨基)-9H-嘌呤.一类新的抗惊厥药.
摘要:合成了抗惊厥嘌呤9-(2-氟苄基)-6-(甲基氨基)-9H-嘌呤(1)的几种取代的芳基和6-烷基氨基类似物,并测试了其对最大电击诱发癫痫发作(mes)的抗惊厥活性.在大鼠中.在芳基部分的5-或6-位具有第二个氟取代基的衍生物具有非常高的活性,Ip Ed50的范围为2-4 Mg / Kg.嘌呤6取代基在许多烷基氨基基团中发生变化的同类物对mes的有效活性与苯妥英相当或比苯妥英好几倍.
Doi:10.1021/jm00400A019

专利信息

专利号:US-4453012-A
优先权日:1982-04-22
标 题 :Process for the preparation of phenyl ketones
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the preparation of phenyl ketones, characterized in that, in a first stage, a halo- or trihalomethylbenzene is reacted with a trihalomethylated aliphatic or aromatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent, and in that, in a second stage, the resultant product is hydrolyzed. The products are used as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.

专利号:US-4454350-A
优先权日:1982-01-21
标题:Process for the acylation of halo- or trihalomethylbenzenes
发明人：DESBOIS MICHEL
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the acylation of halo- or trihalomethylbenzenes, wherein a halo- or trihalomethylbenzene is reacted with a carboxylic acid, a precursor or a derivative thereof in the presence of boron trifluoride in an amount such that the absolute pressure of the boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent. The resultant products are useful as intermediates in the synthesis of compounds having a phytosanitary (e.g., herbicidal) or pharmaceutical activity.

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-2009306392-A1
优先权日:2007-10-19
标题 :Gsm intermediates
发明人：HO CHIH YUNG
权利人:HO CHIH YUNG
摘要:The present invention relates the use of compounds having the general Formula I, wherein the definitions or R 1 and R 2 are provided in the specification. Said compounds of Formula I are useful for the synthesis of a variety of γ-secretase modulators, which are in turn useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.

专利号:US-11731101-B2
优先权日:2016-02-29
标 题 :Modular continuous flow device
发明人：GILMORE KERRY; SEEBERGER PETER H; PIEBER BARTHOLOMAUS; CHATTERJEE SOURAV
权利人:MAX PLANCK GESELLSCHAFT
摘要:The invention refers to a modular continuous flow device for automated chemical multistep synthesis under continuous flow conditions. The device comprises a plurality of different types of continuous flow modules and a valve assembly for connecting the continuous flow modules to each other in a parallel or radial manner. This arrangement allows conducting chemical reaction sequences by pre-synthesizing and intermediately storing or simultaneously synthesizing at least one intermediate product which is needed in the main synthetic reaction sequence in order to obtain the final product.

专利号:US-7825149-B2
优先权日:2006-01-19
标 题 :Substituted imidazoles
发明人：CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
权利人:PFIZER LTD
摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.