CAS: 84624-28-2; H-Lys(Fmoc)-Oh

相似化合物

253138-02-2 10009-20-8 105047-45-8

上下游产品

CAS号84624-27-1 叔丁氧羰基-芴甲氧羰基-赖氨酸 | CAS号849752-39-2 methylN6-(((9H-... | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号657-26-1 L-赖氨酸二盐酸盐 | CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号657-27-2 L-赖氨酸盐酸盐 | CAS号28920-44-7 9H-fluoren-9-yl...

N'-芴甲氧羰基-L-赖氨酸甲酯盐酸盐置于lithium Hydroxide,三乙胺体系中,用 四氢呋喃,二氯甲烷,水 作为反应溶剂,化学反应 0.08H,反应生成 N'-Fmoc-L-赖氨酸
参考文献:Tsc和fmoc氨基保护基之间的正交性和相容性
标题:Tsc和fmoc氨基保护基之间的正交性和相容性
摘要:描述了在tsc和fmoc氨基保护基团之间提供完全正交性的新的脱保护条件.然后,通过使用双重保护的氨基酸(例如tsc-Lys(fmoc)-Oh 4C和fmoc-Lys(tsc)-Oh 4D)有效固相合成分支肽20和21,证明了这些正交脱保护条件的潜力.
DOI:10.1016/j.Tet.2004.12.052

专利信息

专利号:US-2008221303-A1
优先权日:2004-02-18
标 题:Method for the Preparation of Peptide-Oligonucleotide Conjugates
发明人：KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
权利人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
摘要:The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks.

专利号:WO-2025088147-A1
优先权日:2023-10-27
标题 :Theranostic psma-targeting ligands for the diagnosis and treatment of psma-expressing cancers and their solid phase synthesis
发明人：Schäfer Martin; BAUDER-WUEST ULRIKE; ROSCHER MAREIKE; REMDE YVONNE; BENEÅ OVÃ?-SCHÄFER MARTINA; BARINKA CYRIL; KUTILOVÃ? ZSÓFIA; MOTLOVÃ? LUCIA
权利人:DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS
摘要:The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and radiopharmaceuticals for the treatment of various disease states of PSMA-expressing cancers, especially prostate cancer, and metastases thereof. Further the present invention provides synthetic procedures for the synthesis of such PSMA-targeting ligands.

专利号:US-8178531-B2
优先权日:2010-02-23
标 题:Antiviral agents
发明人：OR YAT SUN; WANG GUOQIANG; GAO XURI
权利人:OR YAT SUN; WANG GUOQIANG; GAO XURI; ENANTA PHARM INC
摘要:The present invention relates to antiviral compounds of formula (I), n ncompositions containing these compounds, processes for their preparation, intermediates in their synthesis, and their use as therapeutics for prevention of organ transplantation rejection, the treatment of immune disorders and inflammation, and treatment of viral (particularly hepatitis C viral) infection.

专利号:CN-119823233-A
优先权日:2025-03-18
标题:Synthesis method of retaglutide and retaglutide