CAS: 83882-67-1; 1-(4-(Difluoromethoxy)Phenyl)Ethanone

该化合物是一个氟化芳香酮,其特点是在苯环的准位置存在二氟甲基苯氧组,这一结构特征增强了其在制药和农用化学合成中作为中间体的效用,二氟甲基苯氧混合物可以提高代谢稳定性和生物利用率.复合物在基于碳基的变异中表现出了有利的反应性,使之适合进一步功能化.其高纯度和明确界定的化学特性确保合成应用的一贯性.二氟甲基苯氧组的电镀效应也影响芳香系统的电子特性,使得能够对复杂的有机合成物进行选择性修改.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

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对羟基苯乙酮 4-Hydroxyacetophenone 99-93-4

合成工艺路线路线简述

  • 99-93-4 + 667-27-6 = 83882-67-1
    反应条件:1.1 Reagents: Cesium Carbonate Solvents: Dimethylformamide; 16 H,Rt
    标题:Triple Mode Of Alkylation With Ethyl Bromodifluoroacetate: N,Or O-Difluoromethylation,N-Ethylation And S-(Ethoxycarbonyl)Difluoromethylation
    作者:Polley,Arghya; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2018 卷标:360(21) 页码:4161-4167]

    81290-20-2 = 83882-67-1
    反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; 2 Min,15 °C2.1 Reagents: Potassium Hydroxide Solvents: Dichloromethane,Water; 30 Min,0 °C
    标题:Synthesis Of Gem-Difluorocyclopropa(E)Nes And O-,S-,N-,And P-Difluoromethylated Compounds With Tmscf2Br
    作者:Li,Lingchun; Et Al
    参考文献:Angewandte Chemie 日期:2013 卷标:52(47) 页码:12390-12394]

    2287306-92-5 + 98-86-2 + 37181-39-8 = 83882-67-1 + 101975-23-9 + 127842-55-1
    反应条件:1.1 Catalysts: Tris(2,2′-Bipyridine)Ruthenium(2+) Bis(Hexafluorophosphate) Solvents: Acetonitrile; 12 H,23 °C
    标题:Catalytic Radical Difluoromethoxylation Of Arenes And Heteroarenes
    作者:Lee,Johnny W.; Et Al
    参考文献:Chemical Science 日期:2019 卷标:10(11) 页码:3217-3222]

    98-86-2 + 37181-39-8 = 83882-67-1 + 101975-23-9 + 127842-55-1
    反应条件:1.1 Catalysts: Tris(2,2′-Bipyridine)Ruthenium(2+) Bis(Hexafluorophosphate) Solvents: Acetonitrile; 30 Min
    标题:Visible-Light Photoredox-Catalyzed C(Sp2)-H Difluoromethoxylation Of (Hetero)Arenes Utilizing A Shelf-Stable Pyridinium Reagent
    作者:Lin,Daniel; Et Al
    参考文献:Organic Letters 日期:2022 卷标:24(40) 页码:7255-7259]

    14906-59-3 + 1885-46-7 = 83882-67-1 + 101975-23-9 + 127842-55-1
    反应条件:1.1 Solvents: Acetonitrile; 18 H,66 °C2.1 Catalysts: Tris(2,2′-Bipyridine)Ruthenium(2+) Bis(Hexafluorophosphate) Solvents: Acetonitrile; 30 Min
    标题:Visible-Light Photoredox-Catalyzed C(Sp2)-H Difluoromethoxylation Of (Hetero)Arenes Utilizing A Shelf-Stable Pyridinium Reagent
    作者:Lin,Daniel; Et Al
    参考文献:Organic Letters 日期:2022 卷标:24(40) 页码:7255-7259]

    2287306-91-4 + 333-27-7 = 83882-67-1 + 101975-23-9 + 127842-55-1
    反应条件:1.1 Solvents: 1,2-Dichloroethane; 12 H,60 °C2.1 Catalysts: Tris(2,2′-Bipyridine)Ruthenium(2+) Bis(Hexafluorophosphate) Solvents: Acetonitrile; 12 H,23 °C
    标题:Catalytic Radical Difluoromethoxylation Of Arenes And Heteroarenes
    作者:Lee,Johnny W.; Et Al
    参考文献:Chemical Science 日期:2019 卷标:10(11) 页码:3217-3222]

    100-48-1 = 83882-67-1 + 101975-23-9 + 127842-55-1
    反应条件:1.1 Reagents: Acetic Acid; Rt -> 80 °C; Reflux1.2 Reagents: Hydrogen Peroxide Solvents: Water; 16 H2.1 Solvents: Acetonitrile; 18 H,66 °C3.1 Catalysts: Tris(2,2′-Bipyridine)Ruthenium(2+) Bis(Hexafluorophosphate) Solvents: Acetonitrile; 30 Min
    标题:Visible-Light Photoredox-Catalyzed C(Sp2)-H Difluoromethoxylation Of (Hetero)Arenes Utilizing A Shelf-Stable Pyridinium Reagent
    作者:Lin,Daniel; Et Al
    参考文献:Organic Letters 日期:2022 卷标:24(40) 页码:7255-7259]

    354-08-5 + 99-93-4 = 83882-67-1
    反应条件:1.1 Reagents: Cesium Carbonate Catalysts: Fac-Tris(2-(2-Pyridinyl)Phenyl)Iridium Solvents: Dimethylformamide; 9 H,25 °C
    标题:Visible-Light Photoredox Difluoromethylation Of Phenols And Thiophenols With Commercially Available Difluorobromoacetic Acid
    作者:Yang,Jinyan; Et Al
    参考文献:Organic Letters 日期:2017 卷标:19(10) 页码:2758-2761]

    99-93-4 = 83882-67-1
    反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Tetrabutylammonium Bromide Solvents: Toluene,Water
    标题:Preparation Of Difluoromethoxy- And Difluoromethylthioarenes.
    参考文献:European Patent Organization]

    99-93-4 = 83882-67-1
    反应条件:1.1 Reagents: Potassium Hydroxide,Tetrabutylammonium Bromide Solvents: Water
    标题:Preparation Of (Difluoromethoxy)Phenyl Alkyl Ketones From Hydroxyphenyl Alkyl Ketones
    参考文献:Japan]

    115262-01-6 + 99-93-4 = 83882-67-1
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Dichloromethane,Water; 30 Min,0 °C
    标题:Synthesis Of Gem-Difluorocyclopropa(E)Nes And O-,S-,N-,And P-Difluoromethylated Compounds With Tmscf2Br
    作者:Li,Lingchun; Et Al
    参考文献:Angewandte Chemie 日期:2013 卷标:52(47) 页码:12390-12394]

    65864-64-4 = 83882-67-1
    反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane; 48 H,90 °C2.1 Reagents: Potassium Hydroxide Solvents: Dichloromethane,Water; 30 Min,0 °C
    标题:Synthesis Of Gem-Difluorocyclopropa(E)Nes And O-,S-,N-,And P-Difluoromethylated Compounds With Tmscf2Br
    作者:Li,Lingchun; Et Al
    参考文献:Angewandte Chemie 日期:2013 卷标:52(47) 页码:12390-12394]

    128140-82-9 = 83882-67-1 + 7338-73-0
    反应条件:1.1 Reagents: N-Methylpiperidine,Oxygen Solvents: 1,1,1,3,3,3-Hexafluoro-2-Propanol; 25 H,30 °C
    标题:Metal-Free Photoinduced Transformation Of Aryl Halides And Diketones Into Aryl Ketones
    作者:Yao,Qiuli; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2019 卷标:2019(16) 页码:2721-2724]

    1885-46-7 = 83882-67-1 + 101975-23-9 + 127842-55-1
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: 2-Methyltetrahydrofuran,Water; 12 H,23 °C2.1 Solvents: 1,2-Dichloroethane; 12 H,60 °C3.1 Catalysts: Tris(2,2′-Bipyridine)Ruthenium(2+) Bis(Hexafluorophosphate) Solvents: Acetonitrile; 12 H,23 °C
    标题:Catalytic Radical Difluoromethoxylation Of Arenes And Heteroarenes
    作者:Lee,Johnny W.; Et Al
    参考文献:Chemical Science 日期:2019 卷标:10(11) 页码:3217-3222
📜对羟基苯乙酮置于sodium Hydroxide,四丁基碘化铵体系中,用 1,4-二氧六环,水 作为反应溶剂,化学反应生成 1-[4-(二氟甲氧基)苯基]乙酮
参考文献:Thiazolylamides,Their Preparation,And Their Use For Controlling
标题:Thiazolylamides,Their Preparation,And Their Use For Controlling
摘要:式子为##str1##的噻唑酰胺,其中r.Sup.1为氢或烷基,R.Sup.2为烷基,烯基,炔基或环烷基,R.Sup.3为氢,烷基或卤素,X为卤素,烷氧基,卤代烷氧基,烷基,卤代烷基,环烷基,烷硫基,硝基,氰基,未取代或取代的苯基或未取代或取代的苯氧基,N为1,2,3或4,其制备方法以及用于控制不良植物生长的用途.

海关参考信息

专利信息


专利号:US-2015336866-A1
优先权日:2013-01-01
标题:Synthesis of difluoromethyl ethers and sulfides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

专利号:US-4665074-A
优先权日:1984-05-10
标 题:6-(polyfluoroalkoxyphenyl) pyridazinones, their compositions, synthesis and use
发明人：AMSCHLER HERMANN
权利人:BYK GULDEN LOMBERG CHEM FAB
摘要:6-aryl-3[2H]pyridazinones of formula I (I) in which one of the substituents R1 and R2 denotes hydrogen or (C1-C4)-alkoxy, and the other denotes polyfluoro-(C1-C4)-alkoxy, and their pharmacologically-tolerated salts are suitable as bronchospasmolytic and cardiotonic active compounds. Processes for their preparation and appropriate medicaments are indicated.

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摘要:Zhu, H.; Fan, Q., Science of Synthesis: Knowledge Updates, (2024) 3, 375.
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