CAS: 66335-37-3; 5’-Deoxy-2’,3’-O-Isopropylidene-5-Fluorocytidine
该化合物是一个经过修改的细胞碘核素类比,该化合物在5'位置上具有氟原子特征,与天然核素相比,这增强了其稳定性并改变了其生物活动.2'和3'位置上的异丙基乙酰胺组为氢氧基组提供保护,使其更能抗酶降解.这一改变在核素类比中意义重大,因为它可以影响化合物作为抗病毒或抗癌剂的能力.氟原子的存在还可能影响化合物与核素酸和酶的相互作用,有可能导致药性特性的改变.
- 英文名称5’-Deoxy-2’,3’-O-Isopropylidene-5-Fluorocytidine
- 中文名称5'-脱氧-2',3'-O-异亚丙基-5-氟胞苷
- IUPAC名称4-amino-5-fluoro-1-((3aR,4R,6R,6aR)-2,2,6-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidin-2(1H)-one
- 其它别名5'-Deoxy-5-Fluoro-2',3'-O-Isopropylidene-D-Cytidine; 5'-Deoxy-2',3'-O-Isopropylidene-5-Fluoro-D-Cytidine; 4-Amino-5-Fluoro-1-(2,2,6-Trimethyl-3A,4,6,6A-Tetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)-2-Pyrimidinone; 2',3'-O-Isopropylidene-5'-Deoxy-5-F-Cytidine; Cytidine, 5'-Deoxy-5-Fluoro-2',3'-O-(1-Methylethylidene)-; 5'-Deoxy-5-Fluoro-2',3'-O-Isopropylidene-D-Cytidine Usp/ep/bp; 5'-Deoxy-5-Fluoro-2',3'-O-Isopropylidenecytidine
- CAS编号66335-37-3
- MFCD编号:MFCD07369284
- 分子式:C12H16FN3O4分子量:285.27
- 产品CID: 1644556
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
362-42-5 61787-04-0 66335-39-5物理性质
MSDS等安全信息
上下游产品
2,3-O-isopropylidene-3-O-acetyl-5-deoxy-D-ribose 2-trimethylsilyloxy-4-trimethylsilylamino-5-fluoropyrimidine 5'-deoxy-5-fluor°Cytidine合成工艺路线路线简述
📜5'-脱氧-5-氟-5'-碘-2',3'-O-异亚丙基胞苷 反应生成 5'-脱氧-2',3'-O-异亚丙基-5-氟-D-胞啶
参考文献:Cook,A. F.
标题:Cook,A. F.
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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主要参考文献
参考标题:Synthesis Of Thiol Derivatives Of Biological Active Compounds For Nanotechnology Application作者:Katarzyna Sidoryk,Olga Michalak,Marek Kubiszewski,Andrzej Leś,Marcin Cybulski,Elżbieta U. Stolarczyk,Jan Doubsky
摘要:In Obtaining Different Compounds From Those Designed. Nevertheless, In All Above Cases We Were Able To Obtain Thiol-Containing Derivatives Of Selected Biological Active Compounds. Moreover, A Modelling Study For The Two-Step Thiolation Of Genistein And Some Of Its Derivatives Was Accomplished Using The Density Functional Theory (B3Lp). A Hypothesis On A Possible Reason For The Unsuccessful Deprotection
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